Nature Reviews Urology - Table of Contents alert Volume 13 Issue 6

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TABLE OF CONTENTS
June 2016 Volume 13 Number 6
Impact Factor 4.840 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Diagnosis and treatment of infertility-related male hormonal dysfunction Martin Kathrins & Craig Niederberger
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RESEARCH HIGHLIGHTS Top Kidney cancer: Exosome transmission of sunitinib resistance Published online: 10 May 2016 p297 | doi:10.1038/nrurol.2016.88 PDF Prostate cancer: Exosome RNA expression predicts high-grade disease Published online: 19 April 2016 p298 | doi:10.1038/nrurol.2016.78 PDF Incontinence: Adding mirabegron to solifenacin improves patient outcomes Published online: 04 May 2016 p298 | doi:10.1038/nrurol.2016.86 PDF Prostate cancer: Independent validation of the five-tier grade group system Published online: 04 May 2016 p299 | doi:10.1038/nrurol.2016.83 PDF Prostate cancer: Towards effective combination of ADT and immunotherapy Published online: 26 April 2016 p300 | doi:10.1038/nrurol.2016.80 PDF Pain: MAPPing metabolomic markers for IC/BPS Published online: 26 April 2016 p300 | doi:10.1038/nrurol.2016.81 PDF Kidney cancer: VEGFR-TKI after anti-PD-1 therapy is safe Published online: 04 May 2016 p301 | doi:10.1038/nrurol.2016.79 PDF Prostate cancer: Models to detect high-grade cancer Published online: 10 May 2016 p301 | doi:10.1038/nrurol.2016.82 PDF Bladder cancer: Better prediction of lymph node metastasis Published online: 10 May 2016 p301 | doi:10.1038/nrurol.2016.91 PDF
NEWS AND VIEWS		Top
Bladder cancer: Active surveillance for low-grade Ta bladder tumours Mark S. Soloway Published online: 16 February 2016 p303 | doi:10.1038/nrurol.2016.35 Active surveillance is a safe and cost-effective method to manage patients with recurrent papillary, low-grade, Ta bladder tumours. New long-term data from a large patient cohort confirm previous findings that emphasize the benefits of limiting the number of surgical procedures requiring anaesthesia and hospitalization in these, often elderly, patients. Full Text | PDF
Development: Unique genetic determinants of human kidney development Leif Oxburgh Published online: 10 May 2016 p304 | doi:10.1038/nrurol.2016.87 Human kidneys have many features in common with those of other species, but also unique properties. A detailed human-mouse comparison of the genetic programme governing early events in nephron formation has revealed interspecies differences that could explain how nephron number in adult kidneys is determined. Full Text | PDF
Bladder cancer: Angiogenesis as a therapeutic target in urothelial carcinoma Guru Sonpavde & Joaquim Bellmunt Published online: 13 April 2016 p306 | doi:10.1038/nrurol.2016.69 Angiogenesis has not yet been validated as a therapeutic target in advanced urothelial carcinoma. However, a recent phase II trial has suggested that ramucirumab — a vascular endothelial growth factor (VEGF) receptor-2 antibody — combined with second-line docetaxel, might be beneficial. Full Text | PDF
Prostate cancer: Caveat Emptor — long-term outcomes in the Göteborg active surveillance cohort Christopher P. Filson Published online: 10 May 2016 p307 | doi:10.1038/nrurol.2016.85 Prior reports demonstrate a near-zero risk of prostate-cancer death among patients with very low-risk tumours managed on active surveillance (AS). However, outcomes from an AS cohort in Sweden suggest that observing men with low-risk and intermediate-risk tumours carries a small — but significant — risk of treatment failure and death from prostate cancer. Full Text | PDF
REVIEWS		Top
Diagnosis and treatment of infertility-related male hormonal dysfunction Martin Kathrins & Craig Niederberger Published online: 19 April 2016 p309 | doi:10.1038/nrurol.2016.62 Treatment of infertility-related hormonal dysfunction in men requires an understanding of the hormonal basis of spermatogenesis. However, the best method for accurately determining male androgenization status remains elusive and the tools available for inferring the intratesticular hormonal environment are unreliable. In this Review, the authors discuss the status of our knowledge for diagnosis and treatment of this condition. Abstract | Full Text | PDF
The role of glycans in the development and progression of prostate cancer Jennifer Munkley, Ian G. Mills & David J. Elliott Published online: 19 April 2016 p324 | doi:10.1038/nrurol.2016.65 The prostate glycoproteome can undergo a wide range of different alterations during the occurrence and progression of prostate cancer, which might explain some of the interpatient heterogeneity in disease severity and outcomes. In this Review, the authors describe the potential for alterations in the glycoproteome to provide biomarkers and/or clinical targets for the prognosis and/or treatment of prostate cancer. Abstract | Full Text | PDF
Oncolytic virotherapy for urological cancers Zahid Delwar, Kaixin Zhang, Paul S. Rennie & William Jia Published online: 24 May 2016 p334 | doi:10.1038/nrurol.2016.84 Several oncolytic viruses for the treatment of urological cancers have been investigated in clinical trials. Delwar et al. summarize the challenges encountered to the success of these agents and discuss strategies to improve effectiveness and safety. Abstract | Full Text | PDF
The use of exercise interventions to overcome adverse effects of androgen deprivation therapy Peter Busch Østergren, Caroline Kistorp, Finn Noe Bennedbæk, Jens Faber, Jens Sønksen & Mikkel Fode Published online: 26 April 2016 p353 | doi:10.1038/nrurol.2016.67 Androgen deprivation therapy in men with prostate cancer is associated with several adverse effects. Ostergren and colleagues review the use of exercise interventions to improve physical functioning and mitigate fatigue, changes in body composition and components of metabolic syndrome. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2015. Nature Reviews Urology was previously published as Nature Clinical Practice Urology.

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