Nature Cell Biology contents: August 2016 Volume 18 Number 8, pp 823 - 909

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Advertisement HYBRIBODY enables you to get the cDNA clone of your ELISA & IF validated antibody in a couple of months without animal immunization. Take advantage of our selection & validation service of highly affine single-chain Ab from a humanized synthetic llama VHH library. Watch our video animation to learn more about Hybribody.   Contact our team for more info TABLE OF CONTENTS August 2016 Volume 18, Issue 8 Review News and Views Articles Advertisement   A cell culture plate that can improve your assays Cell culture plates from Eppendorf provide unprecedented reproducibility for your experiments. The innovative design allows for the outer moat of the plate to be filled with liquid, minimizing edge effects and improving assay results. Filling the inter-well space insulates all 96 wells when handled outside the incubator.  Learn how to prevent the edge effect today Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement ATCC Cell Authentication Service Meet your cell authentication requirements for funding, quality control, and publication with the ATCC short tandem repeat (STR) profiling service. Ensure the integrity of your cells and the reproducibility of your data.  Authenticate your cells today!   Advertisement Nature Medicine and the Volkswagen Foundation present:  GENOME EDITING FOR GENE AND CELL THERAPY, A HERRENHAUSEN SYMPOSIUM November 3-4, 2016 | Herrenhausen Palace Conference Center, Hanover, Germany REGISTER NOW!   Advertisement The 4th Helmholtz-Nature Medicine DIABETES CONFERENCE  Accepting abstracts on type 2 diabetes research! September 18-20, 2016 | Lenbach Palais, Munich, Germany REGISTER NOW!   Review Top Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing   pp823 - 832 Navdeep S. Chandel, Heinrich Jasper, Theodore T. Ho and Emmanuelle Passegue doi:10.1038/ncb3385 Passegue and colleagues discuss recent advances in our understanding of the metabolic control of stem cell function, and how stem cell metabolism relates to homeostasis and ageing. News and Views Top p53 mutations promote proteasomal activity   pp833 - 835 Moshe Oren and Eran Kotler doi:10.1038/ncb3392 p53 mutations occur very frequently in human cancer. Besides abrogating the tumour suppressive functions of wild-type p53, many of those mutations also acquire oncogenic gain-of-function activities. Augmentation of proteasome activity is now reported as a common gain-of-function mechanism shared by different p53 mutants, which promotes cancer resistance to proteasome inhibitors. See also: Article by Walerych et al. Hippo's Q for a big liver   pp835 - 837 Dimitrios Anastasiou doi:10.1038/ncb3391 The Hippo pathway is a key regulator of organ size that has also been implicated in tumorigenesis. Yap, one of the effectors of Hippo signalling, is now reported to support these functions by promoting glutamine synthesis. See also: Article by Cox et al. Articles Top Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL   pp839 - 850 Maria Giovanna De Leo, Leopoldo Staiano, Mariella Vicinanza, Alessandro Luciani, Annamaria Carissimo et al. doi:10.1038/ncb3386 De Leo et al. identify a lysosomal response to autophagic cargo during lysosome-autophagosome fusion that involves TLR9 activation and OCRL recruitment, and leads to a regulated local increase in PtdIns(4,5)P2, which is necessary for a normal autophagic flux. Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy   pp851 - 863 Yong Jiang, Alec N. Woosley, Nageswaran Sivalingam, Sneha Natarajan and Philip H. Howe doi:10.1038/ncb3388 Jiang et al. show that Disabled-2 (Dab2) regulates the switch between autophagy and apoptosis in TGB-β-treated cells, through regulation of the Beclin-1-Vps34 interaction. Cell Biology JOBS of the week Research Associate Position in Quantitative Cell Biology University College London (UCL) Professorship (W2) of Evolutionary Cell Biology of Plants (6 Years / Tenure Track) Ludwig-Maximilians-Universität München, Faculty of Biology Professor in Molecular Cell Biology of Cancer University of Gothenburg, Institute of Biomedicine Postdoctoral Positions in Cell Biology University of Pittsburgh Faculty Positions in Cell Biology and Physiology Washington University School of Medicine More Science jobs from Cell Biology EVENT From Metchnikoff to Systems Biology: The Role of Inflammation and Phagocytic Cells in Cancer 29.09.16 Maryland, USA More science events from Advertisement Nature Plants is now accepting submissions! Do you have something in the pipeline? Consider us for your next research paper. Find out how to submit in the Guide to Authors. Submit your research.   Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment   pp864 - 875 Huy Quang Le, Sushmita Ghatak, Ching-Yan Chloe Yeung, Frederik Tellkamp, Christian Gunschmann et al. doi:10.1038/ncb3387 Wickstrom and colleagues describe how mechanical forces applied to epidermal stem cells lead to relocation of emerin to the nuclear envelope and reduced nuclear actin levels, resulting in chromatin changes that influence lineage commitment. F-actin dismantling through a redox-driven synergy between Mical and cofilin   pp876 - 885 Elena E. Grintsevich, Hunkar Gizem Yesilyurt, Shannon K. Rich, Ruei-Jiun Hung, Jonathan R. Terman et al. doi:10.1038/ncb3390 Grintsevich et al. discover that the redox enzyme Mical oxidizes F-actin to promote binding of the F-actin-severing protein cofilin, and that the synergy of Mical and cofilin is necessary and sufficient for F-actin disassembly in Drosophila. Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth   pp886 - 896 Andrew G. Cox, Katie L. Hwang, Kristin K. Brown, Kimberley J. Evason, Sebastian Beltz et al. doi:10.1038/ncb3389 Cox et al. report that Yap induces the expression of glutamine synthetase, thereby elevating glutamine and nitrogen levels for de novo nucleotide synthesis. They show that this promotes hepatomegaly and growth of liver cancer cells in zebrafish. See also: News and Views by Anastasiou Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer   pp897 - 909 Dawid Walerych, Kamil Lisek, Roberta Sommaggio, Silvano Piazza, Yari Ciani et al. doi:10.1038/ncb3380 Walerych et al. show that p53 missense mutants upregulate the proteasome and increase breast cancer cell resistance to proteasome inhibitors. Combined inhibition of p53 mutants and the proteasome leads to increased therapeutic efficacy. See also: News and Views by Oren & Kotler Advertisement npj Regenerative Medicine is an online only, open access, peer-reviewed journal dedicated to publishing high-quality research on ways to help the human body repair, replace and regenerate damaged tissues and organs. The first articles have now been published.  Read the inaugural content   Top Advertisement Established as a sister journal of Cell Research, Cell Discovery is a fully open access journal publishing original articles and reviews on results of significance and originality in all areas of molecular and cell biology. Submit your manuscript.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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