Nature Reviews Immunology Contents August 2016 Volume 16 Number 8 pp 463-524

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TABLE OF CONTENTS
August 2016 Volume 16 Number 8
Impact Factor 30.458 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: The unfolded protein response in immunity and inflammation Joep Grootjans, Arthur Kaser, Randal J. Kaufman & Richard S. Blumberg
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RESEARCH HIGHLIGHTS Top Immunometabolism: Innate sensing role for metabolic enzyme p463 | doi:10.1038/nri.2016.84 The glycolytic enzyme hexokinase can act as an innate sensor of bacterial sugars and trigger inflammasome activation. PDF Macrophages: Memories of the dead give strength p464 | doi:10.1038/nri.2016.81 The uptake of apoptotic corpses generates a molecular memory in macrophages that boosts the innate immune response. PDF Immunometabolism: Mitochondria adapt to bacteria p464 | doi:10.1038/nri.2016.83 Macrophages adjust their mitochondrial respiratory functions in response to viable bacteria. PDF Infectious diseases: Two-pronged attack on HIV p465 | doi:10.1038/nri.2016.87 Two studies identify bispecific antibodies that show broad and potent neutralization of HIV in mouse models. PDF Neuroimmunology: Social support from the immune system p466 | doi:10.1038/nri.2016.85 Interferon-γ acts on inhibitory neurons to regulate social behaviour in mice PDF Mucosal immunology: Glial cells support ILC3s and gut defence p466 | doi:10.1038/nri.2016.86 Production of neurotrophic factors by enteric glial cells controls IL-22 production by ILC3s for barrier defence. PDF JOURNAL CLUB B cell-T cell interaction: antigen bridge to antigen presentation p467 | doi:10.1038/nri.2016.82 Gail Bishop describes a 1985 study by Antonio Lanzavecchia that changed our understanding of B cell-T cell interactions. PDF Immunology JOBS of the week Postdoctoral Fellow in Immunology- Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai Postdoc in Immunology Ludwig-Maximilians-Universität (LMU) in Munich Postdoctoral Fellow in Cancer Biology and Cancer Immunology Fox Chase Cancer Center (FCCC) Postdoctoral Position in Molecular/Cellular Immunology National Institute of Allergy and Infectious Diseases (NIAID) Senior Faculty Leadership Position in Immunology at Fred Hutchinson Cancer Research Center Fred Hutchinson Cancer Research Center More Science jobs from Immunology EVENT Fundamental Immunology Its Therapeutic Potential 25.04.17 Cold Spring Harbor, USA More science events from
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REVIEWS		Top
The unfolded protein response in immunity and inflammation Joep Grootjans, Arthur Kaser, Randal J. Kaufman & Richard S. Blumberg p469 | doi:10.1038/nri.2016.62 The unfolded protein response pathway that is induced by endoplasmic reticulum (ER) stress has important roles in immune cell development and function, which have led to new insights into the pathogenesis of inflammatory diseases. Abstract | Full Text | PDF
Innate sensing of oxidation-specific epitopes in health and disease Christoph J. Binder, Nikolina Papac-Milicevic & Joseph L. Witztum p485 | doi:10.1038/nri.2016.63 Oxidation-specific epitopes (OSEs) function as markers of oxidative damage of membrane lipids. This Review discusses the immune recognition of OSEs, as well as their role in the maintenance of tissue homeostasis and their contribution to the development of inflammatory diseases. Abstract | Full Text | PDF
Combinatorial antibody libraries: new advances, new immunological insights Richard A. Lerner p498 | doi:10.1038/nri.2016.67 Combinatorial antibody libraries have emerged as powerful tools for generating therapeutic antibodies, which are some of the most successful drugs in the world today. This Review provides a brief overview of how these libraries are generated, before focusing on the immunological insights that have arisen from their study. Abstract | Full Text | PDF
Immune responses and immunopathology in acute and chronic viral hepatitis Eui-Cheol Shin, Pil Soo Sung & Su-Hyung Park p509 | doi:10.1038/nri.2016.69 Comparing the immune responses to and immunopathogenesis of infection with hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) provides insight into the distinct outcomes of each type of viral hepatitis. Abstract | Full Text | PDF
PERSPECTIVES		Top
ESSAY Immunity by equilibrium Gérard Eberl p524 | doi:10.1038/nri.2016.75 In this Essay, Gérard Eberl presents a model of immunity that is based on an equilibrium between four types of immune response. Alteration of the internal or microbial environment leads to immune disequilibrium and determines immune protection or pathology. Abstract | Full Text | PDF
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