Nature Reviews Neuroscience contents August 2016 Volume 17 Number 8 pp 463 - 532

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TABLE OF CONTENTS
August 2016 Volume 17 Number 8
Impact Factor 29.298 *	In this issue Research Highlights Reviews Perspectives Correspondence Also this month  Featured article: Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain Tim V. P. Bliss, Graham L. Collingridge, Bong-Kiun Kaang & Min Zhuo
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NEURAL CIRCUITRY OF EMOTION Presented by: Shenzhen Institutes of Advanced Technology, CAS | McGovern Institute for Brain Research at MIT | Nature Neuroscience November 2-4, 2016 | Shenzhen, China REGISTER NOW!
RESEARCH HIGHLIGHTS Top Behavioural neuroscience: On the defensive p463 | doi:10.1038/nrn.2016.88 A disinhibitory circuit involving the central nucleus of the amygdala, inhibitory and excitatory neurons in the ventrolateral periaqueductal grey and premotor neurons in the medulla controls freezing behaviour in response to threat. PDF Neurodevelopmental disorders: Touching on the issue p464 | doi:10.1038/nrn.2016.91 Developmental dysfunction in peripheral somatosensory neurons causes altered responses to tactile stimuli and other behavioural deficits in mouse models of autism spectrum disorder. PDF Synaptic plasticity: Keeping synapses quiet p465 | doi:10.1038/nrn.2016.89 Although both cocaine and morphine administration induce silent synapses in dopaminergic medium spiny neurons and produce similar behavioural changes, they do so through different mechanisms and by affecting different neuronal sub-populations. PDF Synaptic plasticity: Feast or famine p466 | doi:10.1038/nrn.2016.90 AMP-activated protein kinase (AMPK), which is expressed in the hypothalamus and activated by fasting, is shown to increase the phosphorylation of p21-activated kinase 2 (PAK2), and induce spinogenesis and an increase in excitatory neurotransmission in hypothalamic AgRP neurons. PDF Neurophysiology: Local tuning of spike shape p466 | doi:10.1038/nrn.2016.99 In stellate cell axons, axon potential width is determined in a synapse-specific manner by the compartmentalized clustering of Kv3 channels. PDF IN BRIEF Emotion: Fast fear | Metabolism: Promoting obesity | GLIA: Matching the demand | Spatial processing: Route finder PDF Neuroscience JOBS of the week Residency/PhD training program in the field of psychiatrie and neuroscience IMPRS-Translation Psychiatry Postdoctoral Positions Cincinnati Children’s Hospital Medical Center (CCHMC) Director, Neurodegenerative Disease Research Center Arizona State University Postdoctoral Fellowship New York University Associate and Full Professors University of Virginia More Science jobs from Neuroscience EVENT 4th Biennial New Zealand Applied Neurosciences Conference (NZANC) in Auckland 24.11.16 Auckland, New Zeland More science events from
REVIEWS		Top
Autophagy in acute brain injury Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Klas Blomgren & Guido Kroemer p467 | doi:10.1038/nrn.2016.51 Whether autophagy — an intracellular degradation pathway — contributes to or protects against damage following different types of acute brain injury is unclear. Here, Kroemer and colleagues review investigations into the effects of autophagy in excitotoxicity, acute exposure to neurotoxins, neonatal asphyxia, stroke and neurotrauma. Abstract | Full Text | PDF | Supplementary information
Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain Tim V. P. Bliss, Graham L. Collingridge, Bong-Kiun Kaang & Min Zhuo p485 | doi:10.1038/nrn.2016.68 Evidence suggests that activity in the anterior cingulate cortex (ACC) contributes to acute and chronic pain. In this article, Zhuo and colleagues review the different types of synaptic plasticity observed in the ACC and the implications of these forms of plasticity for pain processing. Abstract | Full Text | PDF
Integrating neuroimmune systems in the neurobiology of depression Eric S. Wohleb, Tina Franklin, Masaaki Iwata & Ronald S. Duman p497 | doi:10.1038/nrn.2016.69 Central and peripheral inflammation can be induced by psychological stress and is associated with depressive symptoms, suggesting a possible role for immune dysfunction in depression. Duman and colleagues examine the neuroimmune mechanisms influencing neuronal–microglial interactions, neuronal activity and synaptic plasticity in stress and depression. Abstract | Full Text | PDF
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PERSPECTIVES		Top
OPINION Over the river, through the woods: cognitive maps in the hippocampus and orbitofrontal cortex Andrew M. Wikenheiser & Geoffrey Schoenbaum p513 | doi:10.1038/nrn.2016.56 Recent studies have attributed surprisingly similar functional roles to the orbitofrontal cortex (OFC) and hippocampus. Evidence is presented that both the OFC and hippocampus contribute to 'cognitive mapping', and it is suggested that future work should focus on understanding the functional interactions between these structures. Abstract | Full Text | PDF
OPINION Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression Anthony A. Grace p524 | doi:10.1038/nrn.2016.57 The dopamine system has been implicated in a number of psychiatric disorders, including depression and schizophrenia. Here, Grace describes evidence for disrupted afferent regulation of dopamine neuron firing in these disorders and considers the role of stress in driving this pathology. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Classifying emotion regulation strategies Candace M. Raio, Elizabeth V. Goldfarb, Karolina M. Lempert & Peter Sokol-Hessner p532 | doi:10.1038/nrn.2016.78 Full Text | PDF
Emotion regulation involves both model-based and model-free processes Amit Etkin, Christian Büchel & James J. Gross p532 | doi:10.1038/nrn.2016.79 Full Text | PDF
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