Nature Reviews Endocrinology - Table of Contents alert Volume 12 Issue 9

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TABLE OF CONTENTS
September 2016 Volume 12 Number 9
Impact Factor 15.432*	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Physiological and pathophysiological bone turnover — role of the immune system M. Neale Weitzmann & Ighovwerha Ofotokun
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RESEARCH HIGHLIGHTS Top Diabetes: β-cell heterogeneity — key to unlocking islet regeneration Published online: 22 July 2016 p495 | doi:10.1038/nrendo.2016.122 PDF Stem cells: Calorie restriction affects intestinal cells Published online: 08 July 2016 p496 | doi:10.1038/nrendo.2016.112 PDF Biomarkers: Mannose levels predict insulin resistance Published online: 22 July 2016 p496 | doi:10.1038/nrendo.2016.119 PDF Obesity: Inheritance via mitochondria Published online: 01 July 2016 p497 | doi:10.1038/nrendo.2016.108 PDF Adipose tissue: Sex differences in adipogenesis Published online: 01 July 2016 p497 | doi:10.1038/nrendo.2016.109 PDF Pituitary gland: Understanding pituitary development Published online: 15 July 2016 p497 | doi:10.1038/nrendo.2016.117 PDF Liver: Exercising to reduce risk factors in NAFLD Published online: 22 July 2016 p498 | doi:10.1038/nrendo.2016.120 PDF IN BRIEF NASH: Pioglitazone safe and effective for treating T2DM in patients with NASH | Adrenal function: No difference between CT and AVS for determining treatment options in primary aldosteronism | Diabetes: A metabolomic signature to predict the transition from GDM to T2DM PDF
NEWS AND VIEWS		Top
Obesity: The obesity epidemic in the USA — no end in sight? Jacob C. Seidell & Jutka Halberstadt Published online: 29 July 2016 p499 | doi:10.1038/nrendo.2016.121 Recent data from surveys in the USA have shown that 37.7% of adult individuals and 17.0% of children currently have obesity, with no sign of a reduction despite federal and local obesity prevention strategies. In particular, severe obesity seems to be increasing. Obesity, therefore, remains a major public health problem that requires drastic action. Full Text | PDF
Guidelines: Surgical or medical therapy for patients with obesity and T2DM? Sten Madsbad & Jens J. Holst Published online: 08 July 2016 p500 | doi:10.1038/nrendo.2016.111 Recently, 45 international medical and scientific organizations agreed that bariatric or metabolic surgery should be included among the therapeutic interventions for people with type 2 diabetes mellitus and obesity. The endorsement of these guidelines follows findings that several surgical procedures developed for weight loss improve glycaemia more effectively than any pharmacological or lifestyle approach. Full Text | PDF
Pituitary gland: Mortality in Cushing disease John Newell-Price Published online: 22 July 2016 p502 | doi:10.1038/nrendo.2016.118 A recent study by Clayton et al. shows that overall mortality is increased for patients with Cushing disease, even in remission, but that mortality is normal if long-term remission is induced by only one pituitary surgery. These findings emphasize the importance of expert pituitary surgery. Full Text | PDF
REVIEWS		Top
The potential of endurance exercise-derived exosomes to treat metabolic diseases Adeel Safdar, Ayesha Saleem & Mark A. Tarnopolsky Published online: 27 May 2016 p504 | doi:10.1038/nrendo.2016.76 Here, Mark Tarnopolsky and colleagues propose that the systemic benefits of exercise are mediated by exosomes containing peptides and nucleic acids (exerkines) that act in an autocrine, paracrine and/or endocrine manner. They also discuss the therapeutic potential of using exerkine-enriched native or modified exosomes to treat metabolic diseases such as obesity and type 2 diabetes mellitus. Abstract | Full Text | PDF
Physiological and pathophysiological bone turnover — role of the immune system M. Neale Weitzmann & Ighovwerha Ofotokun Published online: 17 June 2016 p518 | doi:10.1038/nrendo.2016.91 In this Review, Weitzmann and Ofotokun examine the evolution of the field of osteoimmunology and how advances in our understanding of the immuno-skeletal interface might lead to novel approaches to prevent and treat bone loss, and avert fractures. Abstract | Full Text | PDF
Gestational diabetes mellitus: does an effective prevention strategy exist? Rochan Agha-Jaffar, Nick Oliver, Desmond Johnston & Stephen Robinson Published online: 24 June 2016 p533 | doi:10.1038/nrendo.2016.88 Gestational diabetes mellitus (GDM) is associated with considerable risks to both the mother and developing baby. In this article, the authors review the evidence from randomized controlled trials for strategies designed to prevent GDM, such as lifestyle modification, dietary supplementation and pharmacological approaches. Abstract | Full Text | PDF
The chronic syndromes after previous treatment of pituitary tumours Johannes A. Romijn Published online: 03 June 2016 p547 | doi:10.1038/nrendo.2016.84 Despite effective treatments for pituitary tumours, chronic syndromes can occur in patients during long-term follow-up. This Review describes these syndromes, which result from the effects of the initial disease, such as hormonal excess or pituitary insufficiency, and the effects of treatment modalities. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2015. Nature Reviews Endocrinology was previously published as Nature Clinical Practice Endocrinology & Metabolism.

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