Nature Reviews Neurology - Table of Contents alert Volume 13 Issue 1

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TABLE OF CONTENTS
January 2017 Volume 13 Number 1
2015 2-year Impact Factor 18.418 Journal Metrics 2-year Median 13	In this issue Editorial Research Highlights News and Views Reviews Also this month  Featured article: Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy Peter R. Williamson, Joseph N. Jarvis, Anil A. Panackal, Matthew C. Fisher, Síle F. Molloy, Angela Loyse & Thomas S. Harrison
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EDITORIAL		Top
Brains and beauty — the 2017 cover Published online: 28 December 2016 p1 | doi:10.1038/nrneurol.2016.197 Full Text | PDF
RESEARCH HIGHLIGHTS Top Multiple sclerosis: Latitude and vitamin D influence disease course in multiple sclerosis Published online: 18 November 2016 p3 | doi:10.1038/nrneurol.2016.181 PDF Multiple sclerosis: New imaging marker of brain leukocyte infiltration Published online: 25 November 2016 p4 | doi:10.1038/nrneurol.2016.183 PDF Stroke: CT identifies patients in stroke treatment window Published online: 25 November 2016 p4 | doi:10.1038/nrneurol.2016.184 PDF In the news: Highlights from the SfN 2016 Published online: 02 December 2016 p4 | doi:10.1038/nrneurol.2016.191 PDF Alzheimer disease: Sex-specific inflammatory link to early Alzheimer pathology Published online: 09 December 2016 p5 | doi:10.1038/nrneurol.2016.193 PDF Alzheimer disease: BACE1 inhibition could block CSF tau increase Published online: 03 November 2016 p6 | doi:10.1038/nrneurol.2016.170 PDF Motor neuron disease: Brain-computer interface unlocks the mind of a patient with ALS Published online: 02 December 2016 p6 | doi:10.1038/nrneurol.2016.189 PDF Nature Reviews Neurology JOBS of the week Postdoctoral fellow The University of Texas Medical School At Houston More Science jobs from
NEWS AND VIEWS		Top
Gene therapy: Gene-editing therapy for neurological disease Moira A. McMahon & Don W. Cleveland Published online: 16 December 2016 p7 | doi:10.1038/nrneurol.2016.190 Guide RNA-mediated CRISPR-Cas nucleases are a powerful technology for the engineering of mammalian genomes. CRISPR-Cas9-dependent editing of mutated genes that cause Huntington disease and fragile X syndrome was recently achieved in cell-based models, heralding the first step towards developing this technology into viable therapeutics for neurological diseases. Full Text | PDF
Clinical trials: To catch a crook, you might try statistics Gary R. Cutter Published online: 16 December 2016 p9 | doi:10.1038/nrneurol.2016.194 A new systematic review detected strong evidence of unreliable results via use of statistical and logical analyses of 33 randomized clinical trials. Our outrage at these rare occurrences of potential fraud could be rooted in our disdain at our failures in peer review, given that this special effort was required to detect long-running potential fraud. Full Text | PDF
Multiple sclerosis: Is there a safe time to discontinue therapy in MS? Mark S. Freedman Published online: 28 December 2016 p10 | doi:10.1038/nrneurol.2016.192 As yet, no clear strategy has been developed for discontinuation of disease-modifying therapy in multiple sclerosis. A recent observational study adds new information, but the most informative patient groups are still to be assessed comprehensively, and several questions need to be addressed in prospective studies. Full Text | PDF
REVIEWS		Top
Article series: Infections of the CNS Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy Peter R. Williamson et al. Published online: 25 November 2016 p13 | doi:10.1038/nrneurol.2016.167 Cryptococcal meningitis is a major cause of morbidity and mortality in immunocompromized individuals, and, even in apparently immunocompetent individuals, carries a high risk of mortality. Treatment in immunocompromized patients is challenging because these patients are at risk of immune reconstitution inflammatory syndrome (IRIS). This Review summarizes the diagnosis and treatment of cryptococcal disease in various disease. Abstract | Full Text | PDF
Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis Tomas Olsson, Lisa F. Barcellos & Lars Alfredsson Published online: 09 December 2016 p25 | doi:10.1038/nrneurol.2016.187 Lifestyle and environmental factors, some which are potentially modifiable, have important roles in the risk of multiple sclerosis (MS), and some of these risk factors, such as Epstein-Barr virus infection, smoking and obesity in adolescence, interact with genetic risk factors. Here, Olsson and colleagues summarize recent data on modifiable environmental and lifestyle factors in MS, with a focus on gene-environment interactions. Abstract | Full Text | PDF
Article series: Rare diseases Clinical and biological progress over 50 years in Rett syndrome Helen Leonard, Stuart Cobb & Jenny Downs Published online: 09 December 2016 p37 | doi:10.1038/nrneurol.2016.186 Rett syndrome (RTT) is a rare, progressive neurodevelopmental disorder that almost exclusively affects girls, and is caused by a mutation in the MECP2 gene. The authors highlight major milestones in RTT over the past 50 years, and acknowledge the international collaborations that are driving this research programme. Abstract | Full Text | PDF | Supplementary information
Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours Milan T. Makale, Carrie R. McDonald, Jona A. Hattangadi-Gluth & Santosh Kesari Published online: 16 December 2016 p52 | doi:10.1038/nrneurol.2016.185 The majority of patients who receive radiotherapy for brain tumours go on to develop disability, but the pathophysiological mechanisms of radiation-associated cognitive decline remains poorly understood. Here, Makale and colleagues review animal model and patient data on the mechanisms of radiotherapy-associated CNS damage and posit that early damage — occurring before 6 months after irradiation — contributes to long-term cognitive disability. Abstract | Full Text | PDF
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