Scientific Reports Table of Contents e-alert: 31 January 2017

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31 January 2017      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               nature.com webcasts Pixels to data: Quantitative cell biology using high-content imaging and analysis.   Date: Tuesday 28 February 2017   Time: 8AM PST, 11AM EST, 4PM GMT, 5PM CET   Register    Sponsor: PerkinElmer                Jump to the content that matters to you ▼ Biological Sciences   ▼ Chemical Sciences   ▼ Physical Sciences   ▼ Earth & Environmental Sciences   ▼ Health Sciences           Biological Sciences ▲ top               Spheroid arrays for high-throughput single-cell analysis of spatial patterns and biomarker expression in 3D ▶     Delyan P. Ivanov, Anna M. Grabowska     We describe and share a device, methodology and image analysis algorithms, which allow up to 66 spheroids to be arranged into a gel-based array directly from a culture plate for …             Crosstalk between ABO and Forssman (FORS) blood group systems: FORS1 antigen synthesis by ABO gene-encoded glycosyltransferases ▶     Miyako Yamamoto, Emili Cid, Fumiichiro Yamamoto     A and B alleles at the ABO genetic locus specify A and B glycosyltransferases that catalyze the biosynthesis of A and B oligosaccharide antigens, respectively, of blood group ABO …             Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells ▶     Yu-Huei Liu, Yui-Ping Weng, Hsuan-Yuan Lin et al.     Hepatocellular carcinoma (HCC) remains the leading cause of cancer mortality with limited therapeutic targets. The endoplasmic reticulum (ER) plays a pivotal role in maintaining …             The anti-tumor activities of Neferine on cell invasion and oxaliplatin sensitivity regulated by EMT via Snail signaling in hepatocellular carcinoma ▶     Ganlu Deng, Shan Zeng, Junli Ma et al.     Tumor invasion and chemotherapy resistance, which are associated with epithelial-mesenchymal transition (EMT), remain as major challenges in hepatocellular carcinoma (HCC) …             Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus) ▶     Giorgia Beffagna, Cinzia Centelleghe, Giovanni Franzo et al.     Dolphin morbillivirus (DMV) has been deemed as one of the most relevant threats for fin whales (Balaenoptera physalus) being responsible for a mortality outbreak in the …             Effects of jasmonic acid signalling on the wheat microbiome differ between body sites ▶     Hongwei Liu, Lilia C. Carvalhais, Peer M. Schenk et al.     Jasmonic acid (JA) signalling helps plants to defend themselves against necrotrophic pathogens and herbivorous insects and has been shown to influence the root microbiome of …             Whole-transcriptome sequence analysis of differentially expressed genes in Phormium tenax under drought stress ▶     Zhen-yu Bai, Tong Wang, Yin-huan Wu et al.     Phormium tenax is a kind of drought resistant garden plant with its rich and colorful leaves. To clarify the molecular mechanism of drought resistance in Phormium tenax, …             IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis ▶     Michelle S. M. A. Damen, Rabia Agca, Suzanne Holewijn et al.     Patients with rheumatoid arthritis (RA) are at higher risk of developing cardiovascular diseases (CVD). Interleukin (IL)-32 has previously been shown to be involved in the …             Weeding volatiles reduce leaf and seed damage to field-grown soybeans and increase seed isoflavones ▶     Kaori Shiojiri, Rika Ozawa, Ken-Ichi Yamashita et al.     Field experiments were conducted over 3 years (2012, 2013, and 2015), in which half of the young stage soybean plants were exposed to volatiles from cut goldenrods three times …             Isolation and characterization of centromeric repetitive DNA sequences in Saccharum spontaneum ▶     Wenpan Zhang, Sheng Zuo, Zhanjie Li et al.     Sugarcane (Saccharum hybrids spp.) is the most important sugar crop that accounts for ~75% of the world’s sugar production. Recently, a whole-genome sequencing project was …             DOE Optimization of Nano-based Carrier of Pregabalin as Hydrogel: New Therapeutic & Chemometric Approaches for Controlled Drug Delivery Systems ▶     Mona G. Arafa, Bassam M. Ayoub     Niosomes entrapping pregabalin (PG) were prepared using span 60 and cholesterol in different molar ratios by hydration method, the remaining PG from the hydrating solution was …             Efficient Adhesion Culture of Human Pluripotent Stem Cells Using Laminin Fragments in an Uncoated Manner ▶     Takamichi Miyazaki, Takehisa Isobe, Norio Nakatsuji et al.     We describe highly effective adhesion culture of human pluripotent stem cells (hPSCs) using laminin fragments without precoating. Culture substrates have been generally thought …             Imaging tumor microscopic viscosity in vivo using molecular rotors ▶     Lyubov’ E. Shimolina, Maria Angeles Izquierdo, Ismael López-Duarte et al.     The microscopic viscosity plays an essential role in cellular biophysics by controlling the rates of diffusion and bimolecular reactions within the cell interior. While several …             Exploring the dark foldable proteome by considering hydrophobic amino acids topology ▶     Tristan Bitard-Feildel, Isabelle Callebaut     The protein universe corresponds to the set of all proteins found in all organisms. A way to explore it is by taking into account the domain content of the proteins. However, …             Expression and function of NKp46 W32R: the human homologous protein of mouse NKp46 W32R (Noé) ▶     Ariella Glasner, Batya Isaacson, Ofer Mandelboim     Natural killer (NK) cells eradicate infected cells and tumors following the triggering of activating receptors, like the Natural Cytotoxicity Receptors (NCRs), which include …             Time-domain analysis for extracting fast-paced pupil responses ▶     Alexandre Zénon     The eye pupil reacts to cognitive processes, but its analysis is challenging when luminance varies or when stimulation is fast-paced. Current approaches relying on deconvolution …             Clone and functional analysis of Seryl-tRNA synthetase and Tyrosyl-tRNA synthetase from silkworm, Bombyx mori ▶     Jingsheng Hu, Jianghai Tian, Fanchi Li et al.     Aminoacyl-tRNA synthetases are the key enzymes for protein synthesis. Glycine, alanine, serine and tyrosine are the major amino acids composing fibroin of silkworm. Among them, …             Synchronized purification and immobilization of his-tagged β-glucosidase via Fe3O4/PMG core/shell magnetic nanoparticles ▶     Yang Zhou, Shaofei Yuan, Qian Liu et al.     In this paper, an efficient and convenient Fe3O4/PMG/IDA-Ni2+ nanoparticles that applied to purify and immobilize his-tagged β-glucosidase was synthesized, in which, Fe3O4/PMG …             Identification and Characterization of a Plastidic Adenine Nucleotide Uniporter (OsBT1-3) Required for Chloroplast Development in the Early Leaf Stage of Rice ▶     Daoheng Hu, Yang Li, Wenbin Jin et al.     Chloroplast development is an important subject in botany. In this study, a rice (Oryza sativa) mutant exhibiting impairment in early chloroplast development (seedling leaf …             RNA-binding protein RBM3 prevents NO-induced apoptosis in human neuroblastoma cells by modulating p38 signaling and miR-143 ▶     Hai-Jie Yang, Fei Ju, Xin-Xin Guo et al.     Nitric oxide (NO)-induced apoptosis in neurons is an important cause of neurodegenerative disease in humans. The cold-inducible protein RBM3 mediates the protective effects of …             A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency ▶     Arun Kumar Tharkeshwar, Jesse Trekker, Wendy Vermeire et al.     Superparamagnetic iron oxide nanoparticles (SPIONs) have mainly been used as cellular carriers for genes and therapeutic products, while their use in subcellular organelle …             Characterization of faecal microbial communities of dairy cows fed diets containing ensiled Moringa oleifera fodder ▶     Jiajie Sun, Bin Zeng, Zujing Chen et al.     Moringa oleifera (M. oleifera) is a remarkable species with high nutritional value and good biomass production, which can be used as livestock fodder. In this study, we examined …             Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling ▶     Ralph Adams, Rebecca J. Burnley, Chiara R. Valenzano et al.     Protein:protein interactions are fundamental in living organism homeostasis. Here we introduce VHH6, a junctional epitope antibody capable of specifically recognizing a …             Setting temporal baselines for biodiversity: the limits of available monitoring data for capturing the full impact of anthropogenic pressures ▶     Jean-Baptiste Mihoub, Klaus Henle, Nicolas Titeux et al.     Temporal baselines are needed for biodiversity, in order for the change in biodiversity to be measured over time, the targets for biodiversity conservation to be defined and …             DNA damage induced by Strontium-90 exposure at low concentrations in mesenchymal stromal cells: the functional consequences ▶     S. Musilli, N. Nicolas, Z. El Ali et al.     90Sr is one of the radionuclides released after nuclear accidents that can significantly impact human health in the long term. 90Sr accumulates mostly in the bones of exposed …             Fluorescence circadian imaging reveals a PDF-dependent transcriptional regulation of the Drosophila molecular clock ▶     Virginie Sabado, Ludovic Vienne, José Manuel Nunes et al.     Circadian locomotor behaviour is controlled by a pacemaker circuit composed of clock-containing neurons. To interrogate the mechanistic relationship between the molecular …             The Identification of a 1916 Irish Rebel: New Approach for Estimating Relatedness From Low Coverage Homozygous Genomes ▶     Daniel Fernandes, Kendra Sirak, Mario Novak et al.     Thomas Kent was an Irish rebel who was executed by British forces in the aftermath of the Easter Rising armed insurrection of 1916 and buried in a shallow grave on Cork prison’s …             Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy ▶     Carlo Pergola, Katrin Schubert, Simona Pace et al.     Tumour-associated macrophages mainly comprise immunosuppressive M2 phenotypes that promote tumour progression besides anti-tumoural M1 subsets. Selective depletion or …             Opportunistic spawning of tropical anguillid eels Anguilla bicolor bicolor and A. bengalensis bengalensis ▶     Takaomi Arai, Siti Raudah Abdul Kadir     Information on the spawning migration, spawning ecology and life history of tropical eels in the Indo-Pacific region is very limited. The physiological and morphological …             The iSelect 9 K SNP analysis revealed polyploidization induced revolutionary changes and intense human selection causing strong haplotype blocks in wheat ▶     Chenyang Hao, Yuquan Wang, Shiaoman Chao et al.     A Chinese wheat mini core collection was genotyped using the wheat 9 K iSelect SNP array. Total 2420 and 2396 polymorphic SNPs were detected on the A and the B genome …             Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver ▶     Wesam Gamal, Philipp Treskes, Kay Samuel et al.     Dysfunction of cell-cell tight junction (TJ) adhesions is a major feature in the pathogenesis of various diseases. Liver TJs preserve cellular polarity by delimiting functional …             SWATH label-free proteomics analyses revealed the roles of oxidative stress and antioxidant defensing system in sclerotia formation of Polyporus umbellatus ▶     Bing Li, Xiaofang Tian, Chunlan Wang et al.     Understanding the initiation and maturing mechanisms is important for rational manipulating sclerotia differentiation and growth from hypha of Polyporus umbellatus. Proteomes in …             Implication of dorsostriatal D3 receptors in motivational processes: a potential target for neuropsychiatric symptoms in Parkinson’s disease ▶     Mathieu Favier, Carole Carcenac, Guillaume Drui et al.     Beyond classical motor symptoms, motivational and affective deficits are frequently observed in Parkinson’s disease (PD), dramatically impairing the quality of life of patients. …             A comprehensive analysis of the germline and expressed TCR repertoire in White Peking duck ▶     Zhi Yang, Yi Sun, Yonghe Ma et al.     Recently, many immune-related genes have been extensively studied in ducks, but relatively little is known about their TCR genes. Here, we determined the germline and expressed …             Candida albicans stimulates Streptococcus mutans microcolony development via cross-kingdom biofilm-derived metabolites ▶     Dongyeop Kim, Arjun Sengupta, Tagbo H. R. Niepa et al.     Candida albicans is frequently detected with heavy infection of Streptococcus mutans in plaque-biofilms from children affected with early-childhood caries, a prevalent and costly …             Basophil-derived IL-6 regulates TH17 cell differentiation and CD4 T cell immunity ▶     Chae Min Yuk, Hyeung Ju Park, Bo-In Kwon et al.     Basophils are rare, circulating granulocytes proposed to be involved in T helper (TH) type 2 immunity, mainly through secretion of interleukin (IL)-4. In addition to IL-4, …             Computational predictors fail to identify amino acid substitution effects at rheostat positions ▶     M. Miller, Y. Bromberg, L. Swint-Kruse     Many computational approaches exist for predicting the effects of amino acid substitutions. Here, we considered whether the protein sequence position class – rheostat or toggle – …             CASCADE, a platform for controlled gene amplification for high, tunable and selection-free gene expression in yeast ▶     Tomas Strucko, Line Due Buron, Zofia Dorota Jarczynska et al.     Over-expression of a gene by increasing its copy number is often desirable in the model yeast Saccharomyces cerevisiae. It may facilitate elucidation of enzyme functions, and in …             Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons ▶     Pooja Joshi, Martina Gabrielli, Luisa Ponzoni et al.     Fingolimod, also known as FTY720, is an analogue of the sphingolipid sphingosine, which has been proved to be neuroprotective in rodent models of Alzheimer’s disease (AD). …             Modulated DISP3/PTCHD2 expression influences neural stem cell fate decisions ▶     Jana Konířová, Jana Oltová, Alicia Corlett et al.     Neural stem cells (NSCs) are defined by their dual ability to self-renew through mitotic cell division or differentiate into the varied neural cell types of the CNS. DISP3/PTCHD2 …             Ultra-fast cell counters based on microtubular waveguides ▶     Cornelius S. Bausch, Christian Heyn, Wolfgang Hansen et al.     We present a radio-frequency impedance-based biosensor embedded inside a semiconductor microtube for the in-flow detection of single cells. An impedance-matched tank circuit and …             Hollow Au-Ag Nanoparticles Labeled Immunochromatography Strip for Highly Sensitive Detection of Clenbuterol ▶     Jingyun Wang, Lei Zhang, Youju Huang et al.     The probe materials play a significant role in improving the detection efficiency and sensitivity of lateral-flow immunochromatographic test strip (ICTS). Unlike conventional …             Neurophysiological correlates of altered response inhibition in internet gaming disorder and obsessive-compulsive disorder: Perspectives from impulsivity and compulsivity ▶     Minah Kim, Tak Hyung Lee, Jung-Seok Choi et al.     Although internet gaming disorder (IGD) and obsessive-compulsive disorder (OCD) represent opposite ends of the impulsivity and compulsivity dimensions, the two disorders share …             CD133+ cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma ▶     Kai Liu, Meijun Hao, Yabo Ouyang et al.     The role of cancer stem cells (CSCs) in inducing the recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains unclear. Here, we found that a …             Signal mingle: Micropatterns of BMP-2 and fibronectin on soft biopolymeric films regulate myoblast shape and SMAD signaling ▶     Vincent Fitzpatrick, Laure Fourel, Olivier Destaing et al.     In vivo, bone morphogenetic protein 2 (BMP-2) exists both in solution and bound to the extracellular matrix (ECM). While these two modes of presentation are known to influence …             Conversion from long-term cultivated wheat field to Jerusalem artichoke plantation changed soil fungal communities ▶     Xingang Zhou, Jianhui Zhang, Danmei Gao et al.     Understanding soil microbial communities in agroecosystems has the potential to contribute to the improvement of agricultural productivity and sustainability. Effects of …             Quantum Interference and Selectivity through Biological Ion Channels ▶     Vahid Salari, Hamidreza Naeij, Afshin Shafiee     The mechanism of selectivity in ion channels is still an open question in biology for more than half a century. Here, we suggest that quantum interference can be a solution to …             Stress Reactivity in Chronic Tinnitus ▶     Linda T. Betz, Andreas Mühlberger, Berthold Langguth et al.     Tinnitus is primarily an auditory symptom. Yet not only patients and clinicians, but also current pathophysiological models relate the onset and maintenance of tinnitus to …             Establishment and application of a novel isothermal amplification assay for rapid detection of chloroquine resistance (K76T) in Plasmodium falciparum ▶     Madhvi Chahar, Neelima Mishra, Anup Anvikar et al.     Chloroquine (CQ) resistance in Plasmodium falciparum is determined by the mutations in the chloroquine resistance transporter (Pfcrt) gene. The point mutation at codon 76 (K76T), …             Litchi seed extracts diminish prostate cancer progression via induction of apoptosis and attenuation of EMT through Akt/GSK-3β signaling ▶     Hongwei Guo, Hua Luo, Hebao Yuan et al.     Litchi (Litchi chinensisSonnnerat, Sapindaceae), known as Chinese Cherry, is a subtropical fruit tree originating from southern China. Litchi seed extracts have diverse …             Counteracting wetland overgrowth increases breeding and staging bird abundances ▶     Petteri Lehikoinen, Aleksi Lehikoinen, Markku Mikkola-Roos et al.     Human actions have led to loss and degradation of wetlands, impairing their suitability as habitat especially for waterbirds. Such negative effects may be mitigated through …             Cornea organoids from human induced pluripotent stem cells ▶     James W. Foster, Karl Wahlin, Sheila M. Adams et al.     The cornea is the transparent outermost surface of the eye, consisting of a stratified epithelium, a collagenous stroma and an innermost single-cell layered endothelium and …             Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F ▶     S. A. Mireku, M. Ruetz, T. Zhou et al.     BtuCD-F is an ABC transporter that mediates cobalamin uptake into Escherichia coli. Early in vivo data suggested that BtuCD-F might also be involved in the uptake of cobinamide, …             An Oxidoreductase AioE is Responsible for Bacterial Arsenite Oxidation and Resistance ▶     Qian Wang, Yushan Han, Kaixiang Shi et al.     Previously, we found that arsenite (AsIII) oxidation could improve the generation of ATP/NADH to support the growth of Agrobacterium tumefaciens GW4. In this study, we found that …             Nano-biomimetic carriers are implicated in mechanistic evaluation of intracellular gene delivery ▶     Mohsen Alipour, Saman Hosseinkhani, Reza Sheikhnejad et al.     Several tissue specific non-viral carriers have been developed for gene delivery purposes. However, the inability to escape endosomes, undermines the efficacy of these carriers. …             Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping ▶     Xiaofeng Liu, Richard D. Taylor, Laura Griffin et al.     Therapeutic and diagnostic applications of monoclonal antibodies often require careful selection of binders that recognize specific epitopes on the target molecule to exert a …             Accessing the genomic information of unculturable oceanic picoeukaryotes by combining multiple single cells ▶     Jean-François Mangot, Ramiro Logares, Pablo Sánchez et al.     Pico-sized eukaryotes play key roles in the functioning of marine ecosystems, but we still have a limited knowledge on their ecology and evolution. The MAST-4 lineage is of …             Analysis of carotenogenic genes promoters and WRKY transcription factors in response to salt stress in Dunaliella bardawil ▶     Ming-Hua Liang, Jian-Guo Jiang     The unicellular alga Dunaliella bardawil is a highly salt-tolerant organism, capable of accumulating glycerol, glycine betaine and β-carotene under salt stress, and has been …             Population expansion and individual age affect endoparasite richness and diversity in a recolonising large carnivore population ▶     Ines Lesniak, Ilja Heckmann, Emanuel Heitlinger et al.     The recent recolonisation of the Central European lowland (CEL) by the grey wolf (Canis lupus) provides an excellent opportunity to study the effect of founder events on …             Functional characterization of a gibberellin receptor and its application in alfalfa biomass improvement ▶     Xuemin Wang, Jun Li, Liping Ban et al.     Bioactive gibberellins (GAs) are essential phytohormones involved in the regulation of many aspects of plant development. GA receptors are crucial in GA signal transduction in …             Using effect size benchmarks to assess when alien impacts are actually alien ▶     Helen M. Smith, Chris R. Dickman, Peter B. Banks     Alien predators have on average twice the impact on native prey populations than do native predators, and are a severe threat to wildlife globally. Manipulation experiments can …             Physiological performance of the intertidal Manila clam (Ruditapes philippinarum) to long-term daily rhythms of air exposure ▶     Xuwang Yin, Peng Chen, Hai Chen et al.     Intertidal organisms, especially the sessile species, often experience long-term periodic air exposure during their lives. Learning the biochemical and physiological responses of …             Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells ▶     N.-I. Zahaf , A. E. Lang, L. Kaiser et al.     The actin cytoskeleton is an attractive target for bacterial toxins. The ADP-ribosyltransferase TccC3 from the insect bacterial pathogen Photorhabdus luminescence modifies actin …             Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism ▶     Djalma Medeiros, Laíz da Costa Silva-Gonçalves, Annielle Mendes Brito da Silva et al.     Endocannabinoids are amphiphilic molecules that play crucial neurophysiological functions acting as lipid messengers. Antagonists and knockdown of the classical CB1 and CB2 …             Genome-wide divergence, haplotype distribution and population demographic histories for Gossypium hirsutum and Gossypium barbadense as revealed by genome-anchored SNPs ▶     Umesh K. Reddy, Padma Nimmakayala, Venkata Lakshmi Abburi et al.     Use of 10,129 singleton SNPs of known genomic location in tetraploid cotton provided unique opportunities to characterize genome-wide diversity among 440 Gossypium hirsutum and …             Functional characterization of NES and GES responsible for the biosynthesis of (E)-nerolidol and (E,E)-geranyllinalool in Tripterygium wilfordii ▶     Ping Su, Tianyuan Hu, Yujia Liu et al.     Triptolide and celastrol, two principal bioactive compounds in Tripterygium wilfordii, are produced from geranylgeranyl diphosphate (GGPP) and farnesyl diphosphate ((E,E)-FPP) …             ComB proteins expression levels determine Helicobacter pylori competence capacity ▶     Christopher Corbinais, Aurélie Mathieu, Prashant P. Damke et al.     Helicobacter pylori chronically colonises half of the world’s human population and is the main cause of ulcers and gastric cancers. Its prevalence and the increase in antibiotic …             Antimicrobial activity of ProRoot MTA in contact with blood ▶     C. Farrugia, P. Baca, J. Camilleri et al.     Dental materials based on Portland cement, which is used in the construction industry have gained popularity for clinical use due to their hydraulic properties, the interaction …             An Ocular Protein Triad Can Classify Four Complex Retinal Diseases ▶     J. J. W. Kuiper, L. Beretta, S. Nierkens et al.     Retinal diseases generally are vision-threatening conditions that warrant appropriate clinical decision-making which currently solely dependents upon extensive clinical screening …             Both DNA global deformation and repair enzyme contacts mediate flipping of thymine dimer damage ▶     Alexander Knips, Martin Zacharias     The photo-induced cis-syn-cyclobutane pyrimidine (CPD) dimer is a frequent DNA lesion. In bacteria photolyases efficiently repair dimers employing a light-driven reaction after …             Droplet-based microtumor model to assess cell-ECM interactions and drug resistance of gastric cancer cells ▶     Minjeong Jang, Ilkyoo Koh, Seok Jae Lee et al.     Gastric cancer (GC) is a common aggressive malignant tumor with high incidence and mortality worldwide. GC is classified into intestinal and diffuse types according to the …             Quantifying mating success of territorial males and sneakers in a bower-building cichlid fish ▶     I. S. Magalhaes, A. M. Smith, D. A. Joyce     The strategies and traits males evolve to mate with females are incredible in their diversity. Theory on the evolution of secondary sexual characters suggests that evolving any …             M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection ▶     A. R. Piñeros, L. W. Campos, D. M. Fonseca et al.     The protective effects of mycobacterial infections on lung allergy are well documented. However, the inverse relationship between tuberculosis and type 2 immunity is still …             Differentiation of Club Cells to Alveolar Epithelial Cells In Vitro ▶     Dahai Zheng, Boon-Seng Soh, Lu Yin et al.     Club cells are known to function as regional progenitor cells to repair the bronchiolar epithelium in response to lung damage. By lineage tracing in mice, we have shown recently …             Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia ▶     Huilin Huang, Hengyou Weng, Bowen Dong et al.     Inducing degradation of oncoproteins by small molecule compounds has the potential to avoid drug resistance and therefore deserves to be exploited for new therapies. Oridonin is …             Periostin Upregulates Wnt/β-Catenin Signaling to Promote the Osteogenesis of CTLA4-Modified Human Bone Marrow-Mesenchymal Stem Cells ▶     Fei Zhang, Keyu Luo, Zhigang Rong et al.     The enhanced osteogenesis of mesenchymal stem cells (MSCs) modified by expression of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) has been shown in previous studies, but …             Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling ▶     Sarah Marie Henrich, Clemens Usadel, Eugen Werwein et al.     B-Myb, a highly conserved member of the Myb transcription factor family, is expressed ubiquitously in proliferating cells and controls the cell cycle dependent transcription of …             Attention Bias of Avoidant Individuals to Attachment Emotion Pictures ▶     Ying Liu, Yi Ding, Luluzi Lu et al.     How attachment style affects emotion processing is tightly connected with individuals’ attention bias. This experiment explored avoidant individuals’ attentional engagement and …             Sensory and autonomic function and structure in footpads of a diabetic mouse model ▶     Ying Liu, Blessan Sebastian, Ben Liu et al.     Sensory and autonomic neuropathy affects the majority of type II diabetic patients. Clinically, autonomic evaluation often focuses on sudomotor function yet this is rarely …             Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains ▶     Manuel Hora, Martin Carballo-Pacheco, Benedikt Weber et al.     Antibody light chain amyloidosis is a rare disease caused by fibril formation of secreted immunoglobulin light chains (LCs). The huge variety of antibody sequences puts a serious …             Pantoea alhagi, a novel endophytic bacterium with ability to improve growth and drought tolerance in wheat ▶     Chaoqiong Chen, Kaiyun Xin, Hao Liu et al.     A novel strain LTYR-11ZT that exhibited multiple plant growth promoting (PGP) traits was isolated from the surface-sterilized leaves of Alhagi sparsifolia Shap. (Leguminosae), …             How white and black bodies are perceived depends on what emotion is expressed ▶     Rebecca Watson, Beatrice de Gelder     Body language is a powerful indicator of others’ emotions in social interactions, with positive signals triggering approach and negative ones retreat and defensiveness. …             Effects of interspecific interaction-linked habitat factors on moose resource selection and environmental stress ▶     Heng Bao, John M. Fryxell, Hui Liu et al.     Resource selection of herbivores is a complex ecological process that operates in relation to biological or non-biological factors, which may affect the feeding and movement, and …             Discovering novel phenotypes with automatically inferred dynamic models: a partial melanocyte conversion in Xenopus ▶     Daniel Lobo, Maria Lobikin, Michael Levin     Progress in regenerative medicine requires reverse-engineering cellular control networks to infer perturbations with desired systems-level outcomes. Such dynamic models allow …             Intraspecific geographic variation in rod and cone visual pigment sensitivity of a parrot, Platycercus elegans ▶     Ben Knott, Mathew L. Berg, Raoul F. H. Ribot et al.     Variation in wavelength sensitivity among subspecies is unknown among vertebrates. The parrot Platycercus elegans has extreme plumage variation between subspecies ranging from …             Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse ▶     Vanessa Caldeira, Kimberly J. Dougherty, Lotta Borgius et al.     Rhythm generating neurons are thought to be ipsilaterally-projecting excitatory neurons in the thoracolumbar mammalian spinal cord. Recently, a subset of Shox2 interneurons …             Multilevel interaction of the DnaK/DnaJ(HSP70/HSP40) stress-responsive chaperone machine with the central metabolism ▶     Fréderic Anglès, Marie-Pierre Castanié-Cornet, Nawel Slama et al.     Networks of molecular chaperones maintain cellular protein homeostasis by acting at nearly every step in the biogenesis of proteins and protein complexes. Herein, we demonstrate …             Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway ▶     Jialin Duan, Yue Guan, Fei Mu et al.     Hyperglycemia-induced reactive oxygen species (ROS) generation contributes to development of diabetic cardiomyopathy (DCM). This study was designed to determine the effect of an …             Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice ▶     D. Gagnon, S. Petryszyn, M. G. Sanchez et al.     The loss of nigrostriatal dopamine neurons in Parkinson’s disease induces a reduction in the number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D…             The spleen microenvironment influences disease transformation in a mouse model of KITD816V-dependent myeloproliferative neoplasm ▶     Natalie Pelusi, Maike Kosanke, Tamara Riedt et al.     Activating mutations leading to ligand-independent signaling of the stem cell factor receptor KIT are associated with several hematopoietic malignancies. One of the most common …             Astrocyte-derived tissue Transglutaminase affects fibronectin deposition, but not aggregation, during cuprizone-induced demyelination ▶     Nathaly Espitia Pinzon, Berta Sanz-Morello, John J. P. Brevé et al.     Astrogliosis as seen in Multiple Sclerosis (MS) develops into astroglial scarring, which is beneficial because it seals off the site of central nervous system (CNS) damage. …             Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration ▶     Ping Kei Yip, Alejandro Carrillo-Jimenez, Paul King et al.     Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an estimate of 2.5 million people affected per year in …             Modeling pre-metastatic lymphvascular niche in the mouse ear sponge assay ▶     Melissa García-Caballero, Maureen Van de Velde, Silvia Blacher et al.     Lymphangiogenesis, the formation of new lymphatic vessels, occurs in primary tumors and in draining lymph nodes leading to pre-metastatic niche formation. Reliable in vivo models …             Discovery of Cancer Driver Long Noncoding RNAs across 1112 Tumour Genomes: New Candidates and Distinguishing Features ▶     Andrés Lanzós, Joana Carlevaro-Fita, Loris Mularoni et al.     Long noncoding RNAs (lncRNAs) represent a vast unexplored genetic space that may hold missing drivers of tumourigenesis, but few such “driver lncRNAs” are known. Until now, they …             RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis ▶     Claire M. Mooney, Eva M. Jimenez-Mateos, Tobias Engel et al.     The nonsense mediated decay (NMD) pathway is a critical surveillance mechanism for identifying aberrant mRNA transcripts. It is unknown, however, whether the NMD system is …             Protective effects of recombinant human cytoglobin against chronic alcohol-induced liver disease in vivo and in vitro ▶     Jian Wen, Yongbin Wu, Wei Wei et al.     Alcoholic liver disease (ALD) is an important worldwide public health issue with no satisfying treatment available since now. Here we explore the effects of recombinant human …             A de novo deletion mutation in SOX10 in a Chinese family with Waardenburg syndrome type 4 ▶     Xiong Wang, Yaowu Zhu, Na Shen et al.     Waardenburg syndrome type 4 (WS4) or Waardenburg-Shah syndrome is a rare genetic disorder with a prevalence of <1/1,000,000 and characterized by the association of congenital …             Phylogeography of the smooth-coated otter (Lutrogale perspicillata): distinct evolutionary lineages and hybridization with the Asian small-clawed otter (Aonyx cinereus) ▶     Beatrice Moretti, Omar F. Al-Sheikhly, Monica Guerrini et al.     We investigated the phylogeography of the smooth-coated otter (Lutrogale perspicillata) to determine its spatial genetic structure for aiding an adaptive conservation management …             Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress ▶     Mohammad Moshahid Khan, Weng-Lang Yang, Max Brenner et al.     Cold-inducible RNA-binding protein (CIRP), released into the circulation during sepsis, causes lung injury via an as yet unknown mechanism. Since endoplasmic reticulum (ER) …             Prognostic Role of the Pretreatment C-Reactive Protein/Albumin Ratio in Solid Cancers: A Meta-Analysis ▶     Nan Li, Guang-Wei Tian, Ying Wang et al.     The C-reactive protein/albumin ratio (CAR) has been shown to play a significant prognostic role in several cancers. We aimed to comprehensively explore the potential role of the …             Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro ▶     Wei Yi, Jingjing Shi, Guanguan Zhao et al.     Thiazolidinediones (TZD) function as potent anti-diabetic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ), but …             Design and fabrication of a passive droplet dispenser for portable high resolution imaging system ▶     Tahseen Kamal, Rachel Watkins, Zijian Cen et al.     Moldless lens manufacturing techniques using standard droplet dispensing technology often require precise control over pressure to initiate fluid flow and control droplet …             Role of Cytosolic Carboxypeptidase 5 in Neuronal Survival and Spermatogenesis ▶     Hui-Yuan Wu, Peng Wei, James I. Morgan     Proteins may undergo a type of posttranslational modification – polyglutamylation, where a glutamate residue is enzymatically linked to the γ-carboxyl group of a glutamate in the …             RhBMP-2 loaded 3D-printed mesoporous silica/calcium phosphate cement porous scaffolds with enhanced vascularization and osteogenesis properties ▶     Cuidi Li, Chuan Jiang, Yuan Deng et al.     A major limitation in the development of effective scaffolds for bone regeneration has been the limited vascularization of the regenerating tissue. Here, we propose the …             Pyrintegrin Induces Soft Tissue Formation by Transplanted or Endogenous Cells ▶     Bhranti S. Shah, Mo Chen, Takahiro Suzuki et al.     Focal adipose deficiency, such as lipoatrophy, lumpectomy or facial trauma, is a formidable challenge in reconstructive medicine, and yet scarcely investigated in experimental …             Distinguishing Functional DNA Words; A Method for Measuring Clustering Levels ▶     Hanieh Moghaddasi, Khosrow Khalifeh, Amir Hossein Darooneh     Functional DNA sub-sequences and genome elements are spatially clustered through the genome just as keywords in literary texts. Therefore, some of the methods for ranking words …             Combination of IL-6 and sIL-6R differentially regulate varying levels of RANKL-induced osteoclastogenesis through NF-κB, ERK and JNK signaling pathways ▶     Wei Feng, Hongrui Liu, Tingting Luo et al.     Interleukin (IL)-6 is known to indirectly enhance osteoclast formation by promoting receptor activator of nuclear factor kappa-B ligand (RANKL) production by osteoblastic/stromal …             LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974 ▶     Jaewoong Jang, Yoonju Jung, Youngeun Kim et al.     In this study, LPS-induced inflammatory responses in BEAS-2B human bronchial epithelial cells and human umbilical vein endothelial cell (HUVEC)s were found to be prevented by …             Genotyping of human rhinovirus in adult patients with acute respiratory infections identified predominant infections of genotype A21 ▶     Lili Ren, Donghong Yang, Xianwen Ren et al.     Human rhinovirus (HRV) is an important causative agent of acute respiratory tract infections (ARTIs). The roles of specific HRV genotypes in patients suffering from ARTIs have …             Head rice rate measurement based on concave point matching ▶     Yuan Yao, Wei Wu, Tianle Yang et al.     Head rice rate is an important factor affecting rice quality. In this study, an inflection point detection-based technology was applied to measure the head rice rate by combining …             Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication ▶     Kjersti M. Aagaard, Anismrita Lahon, Melissa A. Suter et al.     Zika virus (ZIKV) is an emerging mosquito-borne (Aedes genus) arbovirus of the Flaviviridae family. Although ZIKV has been predominately associated with a mild or asymptomatic …             RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP ▶     Tsung-Yuan Tsai, Wei-Ting Wang, Hao-Kang Li et al.     Multifunctional RNA helicase DDX3 participates in HCV infection, one of the major causes of hepatic steatosis. Here, we investigated the role of DDX3 in hepatic lipid metabolism. …             Low level of swiprosin-1/EFhd2 in vestibular nuclei of spontaneously hypersensitive motion sickness mice ▶     Zhi-Bin Wang, Ping Han, Ling-Chang Tong et al.     Susceptibility to motion sickness (MS) varies considerably among humans. However, the cause of such variation is unclear. Here, we used a classical genetic approach to obtain …             Differentially expressed genes and canonical pathway expression in human atherosclerotic plaques – Tampere Vascular Study ▶     Miska Sulkava, Emma Raitoharju, Mari Levula et al.     Cardiovascular diseases due to atherosclerosis are the leading cause of death globally. We aimed to investigate the potentially altered gene and pathway expression in advanced …             Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis ▶     Jin Liu, Changwei Lu, Xiaohao Wu et al.     The underlying mechanism of the reduced bone formation during the development of glucocorticoid-induced osteoporosis (GIO) remains unclear. Here, we found that the highly …             Survival rate of eukaryotic cells following electrophoretic nanoinjection ▶     Matthias Simonis, Wolfgang Hübner, Alice Wilking et al.     Insertion of foreign molecules such as functionalized fluorescent probes, antibodies, or plasmid DNA to living cells requires overcoming the plasma membrane barrier without …             Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation ▶     Wei-Min Chang, Yuan-Feng Lin, Chia-Yi Su et al.     Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function …             Range expansion underlies historical introgressive hybridization in the Iberian hare ▶     João P. Marques, Liliana Farelo, Joana Vilela et al.     Introgressive hybridization is an important and widespread evolutionary process, but the relative roles of neutral demography and natural selection in promoting massive …             S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects ▶     Sarah E. Antinone, Ghanashyam D. Ghadge, Lyle W. Ostrow et al.     Previously, we found that human Cu, Zn-superoxide dismutase (SOD1) is S-acylated (palmitoylated) in vitro and in amyotrophic lateral sclerosis (ALS) mouse models, and that …             Clusterin: full-length protein and one of its chains show opposing effects on cellular lipid accumulation ▶     Suvarsha Rao Matukumalli, Ramakrishna Tangirala, C. M. Rao     Proteins, made up of either single or multiple chains, are designed to carry out specific biological functions. We found an interesting example of a two-chain protein where …             Fencing bodes a rapid collapse of the unique Greater Mara ecosystem ▶     Mette Løvschal, Peder Klith Bøcher, Jeppe Pilgaard et al.     With land privatization and fencing of thousands of hectares of communal grazing areas, East Africa is struggling with one of the most radical cultural and environmental changes …             Multiple measures could alleviate long-branch attraction in phylogenomic reconstruction of Cupressoideae (Cupressaceae) ▶     Xiao-Jian Qu, Jian-Jun Jin, Shu-Miaw Chaw et al.     Long-branch attraction (LBA) is a major obstacle in phylogenetic reconstruction. The phylogenetic relationships among Juniperus (J), Cupressus (C) and the …             Potential molecular consequences of transgene integration: The R6/2 mouse example ▶     Jessie C. Jacobsen, Serkan Erdin, Colby Chiang et al.     Integration of exogenous DNA into a host genome represents an important route to generate animal and cellular models for exploration into human disease and therapeutic …             Identification of RAN1 orthologue associated with sex determination through whole genome sequencing analysis in fig (Ficus carica L.) ▶     Kazuki Mori, Kenta Shirasawa, Hitoshi Nogata et al.     With the aim of identifying sex determinants of fig, we generated the first draft genome sequence of fig and conducted the subsequent analyses. Linkage analysis with a …             Corrigendum: Design and mechanistic insight into ultrafast calcium indicators for monitoring intracellular calcium dynamics ▶     Nordine Helassa, Borbala Podor, Alan Fine et al.                 The interplay between p16 serine phosphorylation and arginine methylation determines its function in modulating cellular apoptosis and senescence ▶     Yang Lu, Wenlong Ma, Zhongwei Li et al.     Cyclin-dependent kinase inhibitor p16INK4a (p16) primarily functions as a negative regulator of the retinoblastoma protein (Rb) -E2F pathway, thus plays critical role in cell …             Selection of suitable reference genes for quantitative real-time PCR gene expression analysis in Salix matsudana under different abiotic stresses ▶     Yunxing Zhang, Xiaojiao Han, Shuangshuang Chen et al.     Salix matsudana is a deciduous, rapidly growing willow species commonly cultivated in China, which can tolerate drought, salt, and heavy metal stress conditions. Selection of …             Evaluation of the impact of polyclonal infection and heteroresistance on treatment of tuberculosis patients ▶     Mansour Kargarpour Kamakoli, Hamid Reza Sadegh, Ghazaleh Farmanfarmaei et al.     Mixed strain infections of Mycobacterium tuberculosis make diagnosis, treatment, and control of tuberculosis (TB) more difficult. This study was aimed to evaluate the …             Optimal Down Regulation of mRNA Translation ▶     Yoram Zarai, Michael Margaliot, Tamir Tuller     Down regulation of mRNA translation is an important problem in various bio-medical domains ranging from developing effective medicines for tumors and for viral diseases to …             IL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells ▶     Jieliang Shen, Shengxi Xu, Hao Zhou et al.     IL-1β has been reported highly expressed in degenerative intervertebral disc, and our previous study indicated IL-1β facilitates apoptosis of human degenerative nucleus pulposus …             Novel approach for the detection of intraperitoneal micrometastasis using an ovarian cancer mouse model ▶     Ayesha B. Alvero, Dongin Kim, Eydis Lima et al.     Patients with epithelial ovarian cancer have the best overall survival when maximal surgical effort is accomplished. However, despite numerous technological advances, surgery …             A potential role of transposon IS431 in the loss of mecA gene ▶     Aihua Wang, Kai Zhou, Yang Liu et al.     Acquisition of a vancomycin-resistance-determinant may trigger deletion of the mecA gene. However, the molecular mechanisms involved remain largely unknown. In this study, we …             Microencapsulation with alginate/CaCO3: A strategy for improved phage therapy ▶     Joan Colom, Mary Cano-Sarabia, Jennifer Otero et al.     Bacteriophages are promising therapeutic agents that can be applied to different stages of the commercial food chain. In this sense, bacteriophages can be orally administered to …             The neural basis of intergroup threat effect on social attention ▶     Yujie Chen, Yufang Zhao, Hongwen Song et al.     Previous gaze-cuing studies found that intergroup threat is one of the modulators of gaze cuing. These findings indicate that intergroup threat would gate social attention by …             New determinants of olfactory habituation ▶     Charlotte Sinding, François Valadier, Viviana Al-Hassani et al.     Habituation is a filter that optimizes the processing of information by our brain in all sensory modalities. It results in an unconscious reduced responsiveness to continuous or …             Evaluation of TaqMan qPCR System Integrating Two Identically Labelled Hydrolysis Probes in Single Assay ▶     Alexander Nagy, Eliška Vitásková, Lenka Černíková et al.     Ongoing evolution of viral pathogens is a significant issue in diagnostic virology employing TaqMan qPCR/RT-qPCR. Specific concerns are related to false negativity due to probe …             MicroRNA-199a-5p promotes tumour growth by dual-targeting PIAS3 and p27 in human osteosarcoma ▶     Chen Wang, Ximing Ba, Yu Guo et al.     Osteosarcoma (OS) is the most common primary bone malignancy and remains a leading cause of cancer-related deaths in adolescents. Emerging evidence indicates that microRNAs …             Estimating carnivore community structures ▶     José Jiménez, Juan Carlos Nuñez-Arjona, Carmen Rueda et al.     Obtaining reliable estimates of the structure of carnivore communities is of paramount importance because of their ecological roles, ecosystem services and impact on biodiversity …             Imorin: a sexual attractiveness pheromone in female red-bellied newts (Cynops pyrrhogaster) ▶     Tomoaki Nakada, Fumiyo Toyoda, Kouhei Matsuda et al.     The male red-bellied newt (Cynops pyrrhogaster) approaches the female’s cloaca prior to performing any courtship behaviour, as if he is using some released substance to gauge …             The Matrix protein M1 from influenza C virus induces tubular membrane invaginations in an in vitro cell membrane model ▶     David Saletti, Jens Radzimanowski, Gregory Effantin et al.     Matrix proteins from enveloped viruses play an important role in budding and stabilizing virus particles. In order to assess the role of the matrix protein M1 from influenza C …             Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors ▶     Daniel H. Haft, Phillip G. Pierce, Stephen J. Mayclin et al.     During human infection, Mycobacterium tuberculosis (Mtb) survives the normally bacteriocidal phagosome of macrophages. Mtb and related species may be able to combat this harsh …             Listeners can extract meaning from non-linguistic infant vocalisations cross-culturally ▶     Verena Kersken, Klaus Zuberbühler, Juan-Carlos Gomez     We present empirical evidence showing that the acoustic properties of non-linguistic vocalisations produced by human infants in different cultures can be used cross-culturally by …             Haemodynamics Regulate Fibronectin Assembly via PECAM ▶     Zhongming Chen, Chris Givens, John S. Reader et al.     Fibronectin (FN) assembly and fibrillogenesis are critically important in both development and the adult organism, but their importance in vascular functions is not fully …             Corrigendum: Metabolic and Dynamic Profiling for Risk Assessment of Fluopyram, a Typical Phenylamide Fungicide Widely Applied in Vegetable Ecosystem ▶     Peng Wei, Yanan Liu, Wenzhuo Li et al.                 Identification of cardiac progenitors that survive in the ischemic human heart after ventricular myocyte death ▶     Mariko Omatsu-Kanbe, Nozomi Nozuchi, Yuka Nishino et al.     Atypically-shaped cardiomyocytes (ACMs) are beating heart cells identified in the cultures of cardiomyocyte-removed fractions obtained from adult mouse hearts. Since ACMs …             Epigenetic map and genetic map basis of complex traits in cassava population ▶     Meiling Zou, Cheng Lu, Shengkui Zhang et al.     Cassava (Manihot esculenta Crantz) is an important tropical starchy root crop that is adapted to drought but extremely cold sensitive. A cold-tolerant, high-quality, and robust …             Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom ▶     María Salomé Gachet, Alexandra Schubert, Serafina Calarco et al.     The remarkable absence of arachidonic acid (AA) in seed plants prompted us to systematically study the presence of C20 polyunsaturated fatty acids, stearic acid, oleic acid, …             ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain ▶     Birol Cabukusta, Matthijs Kol, Laura Kneller et al.     SMSr/SAMD8 is an ER-resident ceramide phosphoethanolamine synthase with a critical role in controlling ER ceramides and suppressing ceramide-induced apoptosis in cultured cells. …             Intracellular degradation of functionalized carbon nanotube/iron oxide hybrids is modulated by iron via Nrf2 pathway ▶     Dan Elgrabli, Walid Dachraoui, Hélène de Marmier et al.     The in vivo fate and biodegradability of carbon nanotubes is still a matter of debate despite tremendous applications. In this paper we describe a molecular pathway by which …             Mitochondrial and Chromosomal Damage Induced by Oxidative Stress in Zn2+ Ions, ZnO-Bulk and ZnO-NPs treated Allium cepa roots ▶     Bilal Ahmed, Sourabh Dwivedi, Malik Zainul Abdin et al.     Large-scale synthesis and release of nanomaterials in environment is a growing concern for human health and ecosystem. Therefore, we have investigated the cytotoxic and genotoxic …             Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism ▶     Daniel C. Zielinski, Neema Jamshidi, Austin J. Corbett et al.     Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 …             Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain ▶     Jose Vicente Torres-Pérez, Péter Sántha, Angelika Varga et al.     Transcriptional changes in superficial spinal dorsal horn neurons (SSDHN) are essential in the development and maintenance of prolonged pain. Epigenetic mechanisms including …             Comparative molecular dynamics studies of heterozygous open reading frames of DNA polymerase eta (η) in pathogenic yeast Candida albicans ▶     Suresh Satpati, Kodavati Manohar, Narottam Acharya et al.     Genomic instability in Candida albicans is believed to play a crucial role in fungal pathogenesis. DNA polymerases contribute significantly to stability of any genome. Although …             Long-term and realistic global change manipulations had low impact on diversity of soil biota in temperate heathland ▶     Martin Holmstrup, Christian Damgaard, Inger K. Schmidt et al.     In a dry heathland ecosystem we manipulated temperature (warming), precipitation (drought) and atmospheric concentration of CO2 in a full-factorial experiment in order to …             Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling ▶     Liming Yu, Bing Gong, Weixun Duan et al.     Enhancing mitochondrial biogenesis and reducing mitochondrial oxidative stress have emerged as crucial therapeutic strategies to ameliorate diabetic myocardial …             Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na+/K+ ATPase Activity in Dendritic Cells ▶     Zohreh Hosseinzadeh, Yogesh Singh, Derya R. Shimshek et al.     Leucine-rich repeat kinase 2 (Lrrk2) has been implicated in the pathophysiology of Parkinson’s disease. Lrrk2 is expressed in diverse cells including neurons and dendritic cells …             Evidence for positive selection and recombination hotspots in Deformed wing virus (DWV) ▶     A. Dalmon, C. Desbiez, M. Coulon et al.     Deformed wing virus (DWV) is considered one of the most damaging pests in honey bees since the spread of its vector, Varroa destructor. In this study, we sequenced the whole …             Genomic structural variations for cardiovascular and metabolic comorbidity ▶     Maria S. Nazarenko, Aleksei A. Sleptcov, Igor N. Lebedev et al.     The objective of this study was to identify genes targeted by both copy number and copy-neutral changes in the right coronary arteries in the area of advanced atherosclerotic …             Change in microbial community in landfill refuse contaminated with antibiotics facilitates denitrification more than the increase in ARG over long-term ▶     Dong Wu, Guanzhou Chen, Xiaojun Zhang et al.     In this study, the addition of sulfamethazine (SMT) to landfill refuse decreased nitrogen intermediates (e.g. N2O and NO) and dinitrogen (N2) gas fluxes to <0.5 μg-N/kg-refuse·h−1…             Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations ▶     Shuquan Rao, Yao Yao, Joanne Ryan et al.     Rs1344706 in the the zinc finger protein 804A (ZNF804A) gene has been identified to be associated with schizophrenia and bipolar disorder (BD) in Europeans. However, whether …             Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor ▶     César S. Huertas, Santos Domínguez-Zotes, Laura M. Lechuga     Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects …             High Quality Bioreplication of Intricate Nanostructures from a Fragile Gecko Skin Surface with Bactericidal Properties ▶     David William Green, Kenneth Ka-Ho Lee, Jolanta Anna Watson et al.     The external epithelial surfaces of plants and animals are frequently carpeted with small micro- and nanostructures, which broadens their adaptive capabilities in challenging …             Mechanistic insights into the impact of Cold Atmospheric Pressure Plasma on human epithelial cell lines ▶     Marlène Dezest, Laurent Chavatte, Marion Bourdens et al.     Compelling evidence suggests that Cold Atmospheric Pressure Plasma (CAPP) has potential as a new cancer therapy. However, knowledge about cellular signaling events and toxicity …             Antimicrobial Nanoplexes meet Model Bacterial Membranes: the key role of Cardiolipin ▶     Alejandro Marín-Menéndez, Costanza Montis, Teresa Díaz-Calvo et al.     Antimicrobial resistance to traditional antibiotics is a crucial challenge of medical research. Oligonucleotide therapeutics, such as antisense or Transcription Factor Decoys …             Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity ▶     Yukti Choudhury, Yi Chin Toh, Jiangwa Xing et al.     Idiosyncratic drug-induced hepatotoxicity is a major cause of liver damage and drug pipeline failure, and is difficult to study as patient-specific features are not readily …             Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress ▶     Karine Salin, Sonya K. Auer, Eugenia M. Villasevil et al.     In recent years evolutionary ecologists have become increasingly interested in the effects of reactive oxygen species (ROS) on the life-histories of animals. ROS levels have …             Corrigendum: Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay ▶     Wim Trypsteen, Pejman Mohammadi, Clarissa Van Hecke et al.                 Identification of consensus biomarkers for predicting non-genotoxic hepatocarcinogens ▶     Shan-Han Huang, Chun-Wei Tung     The assessment of non-genotoxic hepatocarcinogens (NGHCs) is currently relying on two-year rodent bioassays. Toxicogenomics biomarkers provide a potential alternative method for …             Candidate pheromone receptors of codling moth Cydia pomonella respond to pheromones and kairomones ▶     Alberto Maria Cattaneo, Francisco Gonzalez, Jonas M. Bengtsson et al.     Olfaction plays a dominant role in the mate-finding and host selection behaviours of the codling moth (Cydia pomonella), an important pest of apple, pear and walnut orchards …             Overlap Extension Barcoding for the Next Generation Sequencing and Genotyping of Plasmodium falciparum in Individual Patients in Western Kenya ▶     Brandt Levitt, Andrew Obala, Scott Langdon et al.     Large-scale molecular epidemiologic studies of Plasmodium falciparum parasites have provided insights into parasite biology and transmission, can identify the spread of drug …             IL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide ▶     Wei Zhong, Ling Zhao, Tao Liu et al.     T cells are key players in immune-mediated rheumatoid arthritis (RA). We previously reported that interleukin (IL)-22+CD4+T helper (IL-22+ Th) cells and IL-22 critically control …             Quantification of spatiotemporal patterns of Ras isoform expression during development ▶     Anna U. Newlaczyl, Judy M. Coulson, Ian A. Prior     Ras proteins are important signalling hubs frequently dysregulated in cancer and in a group of developmental disorders called Rasopathies. Three Ras genes encode four proteins …             Corrigendum: Pre- and post-weaning diet alters the faecal metagenome in the cat with differences in vitamin and carbohydrate metabolism gene abundances ▶     Wayne Young, Christina D. Moon, David G. Thomas et al.                 Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis ▶     Tobias V. Lanz, Sarah K. Williams, Aleksandar Stojic et al.     The catabolism of tryptophan to immunosuppressive and neuroactive kynurenines is a key metabolic pathway regulating immune responses and neurotoxicity. The rate-limiting step is …             A visual processing advantage for young-adolescent deaf observers: Evidence from face and object matching tasks ▶     Ahmed M. Megreya, Markus Bindemann     It is unresolved whether the permanent auditory deprivation that deaf people experience leads to the enhanced visual processing of faces. The current study explored this question …             Preparation and execution of teeth clenching and foot muscle contraction influence on corticospinal hand-muscle excitability ▶     Naeem Komeilipoor, Risto J. Ilmoniemi, Kaisa Tiippana et al.     Contraction of a muscle modulates not only the corticospinal excitability (CSE) of the contracting muscle but also that of different muscles. We investigated to what extent the …             CCL2 deficient mesenchymal stem cells fail to establish long-lasting contact with T cells and no longer ameliorate lupus symptoms ▶     Hong Kyung Lee, Hyung Sook Kim, Ji Sung Kim et al.     Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease characterized by autoantibody production. Mesenchymal stem cells (MSCs) ameliorate SLE symptoms by …             Males develop faster and more severe hepatocellular carcinoma than females in krasV12 transgenic zebrafish ▶     Yan Li, Hankun Li, Jan M. Spitsbergen et al.     Hepatocellular carcinoma (HCC) is more prevalent in men than women, but the reason for this gender disparity is not well understood. To investigate whether zebrafish could be …             Newborn chicks show inherited variability in early social predispositions for hen-like stimuli ▶     Elisabetta Versace, Ilaria Fracasso, Gabriele Baldan et al.     Predispositions of newborn vertebrates to preferentially attend to living beings and learn about them are pervasive. Their disturbance (e.g. in neonates at risk for autism), may …             Ligand binding pocket of a novel Allatostatin receptor type C of stick insect, Carausius morosus ▶     Burcin Duan Sahbaz, Osman Ugur Sezerman, Hamdi Torun et al.     Allatostatins (AST) are neuropeptides with variable function ranging from regulation of developmental processes to the feeding behavior in insects. They exert their effects by …             Time-of-Day Dictates Transcriptional Inflammatory Responses to Cytotoxic Chemotherapy ▶     Jeremy C. Borniger, William H. Walker II, Monica M. Gaudier-Diaz et al.     Many cytotoxic chemotherapeutics elicit a proinflammatory response which is often associated with chemotherapy-induced behavioral alterations. The immune system is under …             CD5 molecule-like and transthyretin as putative biomarkers of chronic myeloid leukemia - an insight from the proteomic analysis of human plasma ▶     Iram Fatima, Saima Sadaf, Syed Ghulam Musharraf et al.     Better and sensitive biomarkers are needed to help understand the mechanism of disease onset, progression, prognosis and monitoring of the therapeutic response. Aim of this study …             SWATH-based proteomics identified carbonic anhydrase 2 as a potential diagnosis biomarker for nasopharyngeal carcinoma ▶     Yanzhang Luo, Tin Seak Mok, Xiuxian Lin et al.     Nasopharyngeal carcinoma (NPC) is a serious threat to public health, and the biomarker discovery is of urgent needs. The data-independent mode (DIA) based sequential window …             The identification and molecular mechanism of anti-stroke traditional Chinese medicinal compounds ▶     Jia-Qian Liu, Shao-Xing Dai, Jun-Juan Zheng et al.     Stroke is a worldwide epidemic disease with high morbidity and mortality. The continuously exploration of anti-stroke medicines and molecular mechanism has a long way to go. In …             Safety assessment of Staphylococcus phages of the family Myoviridae based on complete genome sequences ▶     Zelin Cui, Xiaokui Guo, Ke Dong et al.     Staphylococcus phages of the Myoviridae family have a wide host range and potential applications in phage therapy. In this report, safety assessments of these phages were …             Fine mapping genetic associations between the HLA region and extremely high intelligence ▶     Delilah Zabaneh, Eva Krapohl, Michael A. Simpson et al.     General cognitive ability (intelligence) is one of the most heritable behavioural traits and most predictive of socially important outcomes and health. We hypothesized that some …             Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease ▶     Alba Di Pardo, Enrico Amico, Francesco Scalabrì et al.     Blood-brain barrier (BBB) breakdown, due to the concomitant disruption of the tight junctions (TJs), normally required for the maintenance of BBB function, and to the altered …             Focusing and alignment of erythrocytes in a viscoelastic medium ▶     Taesik Go, Hyeokjun Byeon, Sang Joon Lee     Viscoelastic fluid flow-induced cross-streamline migration has recently received considerable attention because this process provides simple focusing and alignment over a wide …             Chemically-activatable alkyne-tagged probe for imaging microdomains in lipid bilayer membranes ▶     Satoshi Yamaguchi, Taku Matsushita, Shin Izuta et al.     A chemically-activatable alkynyl steroid analogue probe has been synthesized for visualizing the lipid raft membrane domains by Raman microscopy. The Raman probe, in which ring A …             Gender differences in cognitive Theory of Mind revealed by transcranial direct current stimulation on medial prefrontal cortex ▶     Mauro Adenzato, Michela Brambilla, Rosa Manenti et al.     Gender differences in social cognition are a long discussed issue, in particular those concerning Theory of Mind (ToM), i.e., the ability to explain and predict other people’s …             Culture adaptation of malaria parasites selects for convergent loss-of-function mutants ▶     Antoine Claessens, Muna Affara, Samuel A. Assefa et al.     Cultured human pathogens may differ significantly from source populations. To investigate the genetic basis of laboratory adaptation in malaria parasites, clinical Plasmodium …             Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury ▶     Yilong Ren, Yan Ao, Timothy M. O’Shea et al.     Ependyma have been proposed as adult neural stem cells that provide the majority of newly proliferated scar-forming astrocytes that protect tissue and function after spinal cord …             RNA interference-mediated knockdown of the hydroxyacid-oxoacid transhydrogenase gene decreases thiamethoxam resistance in adults of the whitefly Bemisia tabaci ▶     Xin Yang, Wen Xie, Ru-mei Li et al.     Bemisia tabaci has developed a high level of resistance to thiamethoxam, a second generation neonicotinoid insecticide that has been widely used to control this pest. In this …             A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk ▶     Rachel J. J. Elands, Colinda C. J. M. Simons, Mona Riemenschneider et al.     Data from GWAS suggest that SNPs associated with complex diseases or traits tend to co-segregate in regions of low recombination, harbouring functionally linked gene clusters. …             Whole-exome sequencing of 228 patients with sporadic Parkinson’s disease ▶     Cynthia Sandor, Frantisek Honti, Wilfried Haerty et al.     Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, affecting 1% of the population over 65 years characterized clinically by both motor and non-motor …             Comparative evaluation of rRNA depletion procedures for the improved analysis of bacterial biofilm and mixed pathogen culture transcriptomes ▶     Olga E. Petrova, Fernando Garcia-Alcalde, Claudia Zampaloni et al.     Global transcriptomic analysis via RNA-seq is often hampered by the high abundance of ribosomal (r)RNA in bacterial cells. To remove rRNA and enrich coding sequences, subtractive …             The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression ▶     L. M. Almassalha, A. Tiwari, P. T. Ruhoff et al.     Most of what we know about gene transcription comes from the view of cells as molecular machines: focusing on the role of molecular modifications to the proteins carrying out …             Growth rate control of flagellar assembly in Escherichia coli strain RP437 ▶     Martin Sim, Santosh Koirala, David Picton et al.     The flagellum is a rotary motor that enables bacteria to swim in liquids and swarm over surfaces. Numerous global regulators control flagellar assembly in response to cellular …             A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability ▶     Michele Vasaturo, Lorenzo Fiengo, Nunziatina De Tommasi et al.     Proteomics based approaches are emerging as useful tools to identify the targets of bioactive compounds and elucidate their molecular mechanisms of action. Here, we applied a …             Allosteric Inhibition of Phosphoenolpyruvate Carboxylases is Determined by a Single Amino Acid Residue in Cyanobacteria ▶     Masahiro Takeya, Masami Yokota Hirai, Takashi Osanai     Phosphoenolpyruvate carboxylase (PEPC) is an important enzyme for CO2 fixation and primary metabolism in photosynthetic organisms including cyanobacteria. The kinetics and …             Interaction between facial expression and color ▶     Kae Nakajima, Tetsuto Minami, Shigeki Nakauchi     Facial color varies depending on emotional state, and emotions are often described in relation to facial color. In this study, we investigated whether the recognition of facial …             Body size and vocalization in primates and carnivores ▶     D. L. Bowling, M. Garcia, J. C. Dunn et al.     A fundamental assumption in bioacoustics is that large animals tend to produce vocalizations with lower frequencies than small animals. This inverse relationship between body …             Dopaminergic modulation of performance monitoring in Parkinson’s disease: An event-related potential study ▶     Caroline Seer, Florian Lange, Sebastian Loens et al.     Monitoring one’s actions is essential for goal-directed performance. In the event-related potential (ERP), errors are followed by fronto-centrally distributed negativities. These …             Insights into the Planktothrix genus: Genomic and metabolic comparison of benthic and planktic strains ▶     Claire Pancrace, Marie-Anne Barny, Reiko Ueoka et al.     Planktothrix is a dominant cyanobacterial genus forming toxic blooms in temperate freshwater ecosystems. We sequenced the genome of planktic and non planktic Planktothrix strains …             Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis ▶     Sabrina Cipriani, Adriana Carino, Dario Masullo et al.     The small heterodimer partner (SHP) is an orphan nuclear receptor that lacks the DNA binding domain while conserves a putative ligand-binding site, thought that endogenous …             Minimizing the risk of allo-sensitization to optimize the benefit of allogeneic cardiac-derived stem/progenitor cells ▶     Hocine R. Hocine, Hicham E. L. Costa, Noemie Dam et al.     Allogeneic human cardiac-derived stem/progenitor cells (hCPC) are currently under clinical investigation for cardiac repair. While cellular immune response against allogeneic …             MoVrp1, a putative verprolin protein, is required for asexual development and infection in the rice blast fungus Magnaporthe oryzae ▶     Lin Huang, Shengpei Zhang, Ziyi Yin et al.     Endocytosis is a crucial cellular process in eukaryotic cells which involves clathrin and/or adaptor proteins, lipid kinases, phosphatases and the actin cytoskeleton. Verprolin …             Production of functional human nerve growth factor from the saliva of transgenic mice by using salivary glands as bioreactors ▶     Fang Zeng, Zicong Li, Qingchun Zhu et al.     The salivary glands of animals have great potential to act as powerful bioreactors to produce human therapeutic proteins. Human nerve growth factor (hNGF) is an important …             The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels ▶     Christina Valkova, Lutz Liebmann, Andreas Krämer et al.     Rer1 is a sorting receptor in the early secretory pathway that controls the assembly and the cell surface transport of selected multimeric membrane protein complexes. Mice with a …             Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway ▶     Zhangxiao Peng, Yan Wang, Jianhui Fan et al.     Our previous studies demonstrated that volatile oil from saussurea lappa root (VOSL), rich in two natural sesquiterpene lactones, costunolide (Cos) and dehydrocostuslactone …             Membrane Perturbation of ADP-insensitive Phosphoenzyme of Ca2+-ATPase Modifies Gathering of Transmembrane Helix M2 with Cytoplasmic Domains and Luminal Gating ▶     Stefania Danko, Kazuo Yamasaki, Takashi Daiho et al.     Ca2+ transport by sarcoplasmic reticulum Ca2+-ATPase involves ATP-dependent phosphorylation of a catalytic aspartic acid residue. The key process, luminal Ca2+ release occurs …             PrimerSuite: A High-Throughput Web-Based Primer Design Program for Multiplex Bisulfite PCR ▶     Jennifer Lu, Andrew Johnston, Philippe Berichon et al.     The analysis of DNA methylation at CpG dinucleotides has become a major research focus due to its regulatory role in numerous biological processes, but the requisite need for …             The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells ▶     Clementina Sansone, Christian Galasso, Ida Orefice et al.     Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an …             PtoMYB156 is involved in negative regulation of phenylpropanoid metabolism and secondary cell wall biosynthesis during wood formation in poplar ▶     Li Yang, Xin Zhao, Lingyu Ran et al.     Some R2R3 MYB transcription factors have been shown to be major regulators of phenylpropanoid biosynthetic pathway and impact secondary wall formation in plants. In this study, …             Characterization of novel Acidobacteria exopolysaccharides with potential industrial and ecological applications ▶     Anna M. Kielak, Tereza C. L. Castellane, Joao C. Campanharo et al.     Acidobacteria have been described as one of the most abundant and ubiquitous bacterial phyla in soil. However, factors contributing to this ecological success are not well …             Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression ▶     Andrey A. Bobko, Timothy D. Eubank, Benoit Driesschaert et al.     Noninvasive in vivo assessment of chemical tumor microenvironment (TME) parameters such as oxygen (pO2), extracellular acidosis (pHe), and concentration of interstitial inorganic …             Identification of Key Residues for Urate Specific Transport in Human Glucose Transporter 9 (hSLC2A9) ▶     Wentong Long, Rashmi Panigrahi, Pankaj Panwar et al.     Human glucose transporter 9 (hSLC2A9) is critical in human urate homeostasis, for which very small deviations can lead to chronic or acute metabolic disorders. Human SLC2A9 is …             NLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy ▶     Yu-Ling Tsai, Kuo-Feng Hua, Ann Chen et al.     We have previously showed that IL-1β is involved in the pathogenesis of both spontaneously occurring and passively induced IgA nephropathy (IgAN) models. However, the exact …             Treatment effects of lysozyme-shelled microbubbles and ultrasound in inflammatory skin disease ▶     Ai-Ho Liao, Chi-Ray Hung, Chieh-Fu Lin et al.     Acne vulgaris is the most common skin disorder, and is caused by Propionibacterium acnes (P. acnes) and can induce inflammation. Antibiotic therapy often needs to be administered …             The aliphatic amidase AmiE is involved in regulation of Pseudomonas aeruginosa virulence ▶     Thomas Clamens, Thibaut Rosay, Alexandre Crépin et al.     We have previously shown that the eukaryotic C-type natriuretic peptide hormone (CNP) regulates Pseudomonas aeruginosa virulence and biofilm formation after binding on the AmiC …             Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium ▶     Hanlu Fan, Xiaohong Du, Jingyuan Zhang et al.     The Ebola crisis occurred in West-Africa highlights the urgency for its clinical treatments. Currently, no Food and Drug Administration (FDA)-approved therapeutics are available. …             Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib ▶     Arancha Cebrián, Teresa Gómez del Pulgar, María José Méndez-Vidal et al.     Sunitinib is the currently standard treatment for metastatic renal cell carcinoma (mRCC). Multiple candidate predictive biomarkers for sunitinib response have been evaluated but …             Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana ▶     Chang-Bum Jeong, Hye-Min Kang, Min-Chul Lee et al.     Microplastic pollution causes a major concern in the marine environment due to their worldwide distribution, persistence, and adverse effects of these pollutants in the marine …             Biological Membrane-Packed Mesenchymal Stem Cells Treat Acute Kidney Disease by Ameliorating Mitochondrial-Related Apoptosis ▶     Xiaodong Geng, Quan Hong, Weiwei Wang et al.     The mortality of rhabdomyolysis-induced AKI remains high because no effective therapy exists. We investigated a new therapeutic method using MSCs. The aim of this study was to …             Selection of reference genes is critical for miRNA expression analysis in human cardiac tissue. A focus on atrial fibrillation ▶     Michela Masè, Margherita Grasso, Laura Avogaro et al.     MicroRNAs (miRNAs) are emerging as key regulators of complex biological processes in several cardiovascular diseases, including atrial fibrillation (AF). Reverse …             The relationship between vacuolation and initiation of PCD in rice (Oryza sativa) aleurone cells ▶     Yan Zheng, Heting Zhang, Xiaojiang Deng et al.     Vacuole fusion is a necessary process for the establishment of a large central vacuole, which is the central location of various hydrolytic enzymes and other factors involved in …             A new serotonin 5-HT6 receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding ▶     Juan A. González-Vera, Rocío A. Medina, Mar Martín-Fontecha et al.     Serotonin 5-HT6 receptor has been proposed as a promising therapeutic target for cognition enhancement though the development of new antagonists is still needed to validate these …             Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells ▶     Nami Kim, Miso Nam, Mi Sun Kang et al.     This study characterizes the human metabolic response to piperine, a curcumin extract, and the details of its underlying molecular mechanism. Using 1H-NMR-based metabolome …             Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes ▶     Carmelo Milioto, Adriana Malena, Eleonora Maino et al.     Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease characterized by the loss of lower motor neurons. SBMA is caused by expansions of a polyglutamine tract in …                 Chemical Sciences ▲ top               A robust, highly stretchable supramolecular polymer conductive hydrogel with self-healability and thermo-processability ▶     Qian Wu, Junjie Wei, Bing Xu et al.     Dual amide hydrogen bond crosslinked and strengthened high strength supramolecular polymer conductive hydrogels were fabricated by simply in situ doping poly (N-acryloyl …             Poly(carboxylate ether)-based superplasticizer achieves workability retention in calcium aluminate cement ▶     Omid Akhlaghi, Yusuf Ziya Menceloglu, Ozge Akbulut     Calcium aluminate cement (CAC) suffers from loss of workability in less than an hour (~15 minutes) after first touch of water. Current superplasticizers that are utilized to …             Solar-Pumping Upconversion of Interfacial Coordination Nanoparticles ▶     Ayumi Ishii, Miki Hasegawa     An interfacial coordination nanoparticle successfully exhibited an upconversion blue emission excited by very low-power light irradiation, such as sunlight. The interfacial …             Hydrocracking of Jatropha Oil over non-sulfided PTA-NiMo/ZSM-5 Catalyst ▶     Xiaosong Yang, Jing Liu, Kai Fan et al.     The PTA-NiMo/ZSM-5 catalyst impregnated with phosphotungstic acid (PTA) was designed for the transformation of Jatropha oil into benzene, toluene, and xylenes (BTX) aromatics. …             Magnetocaloric effect and negative thermal expansion in hexagonal Fe doped MnNiGe compounds with a magnetoelastic AFM-FM-like transition ▶     Kun Xu, Zhe Li, Enke Liu et al.     We report a detailed study of two successive first-order transitions, including a martensitic transition (MT) and an antiferromagnetic (AFM)-ferromagnetic (FM)-like transition, …             Emergent Properties of Giant Vesicles Formed by a Polymerization-Induced Self-Assembly (PISA) Reaction ▶     Anders N. Albertsen, Jan K. Szymański, Juan Pérez-Mercader     Giant micrometer sized vesicles are of obvious interest to the natural sciences as well as engineering, having potential application in fields ranging from drug delivery to …             Hexagonal tungsten oxide nanoflowers as enzymatic mimetics and electrocatalysts ▶     Chan Yeong Park, Ji Min Seo, Hongil Jo et al.     Tungsten oxide (WOx) has been widely studied for versatile applications based on its photocatalytic, intrinsic catalytic, and electrocatalytic properties. Among the several …             Temperature dependent CO2 behavior in microporous 1-D channels of a metal-organic framework with multiple interaction sites ▶     Dongwook Kim, Jaehun Park, Yung Sam Kim et al.     The MOF with the encapsulated CO2 molecule shows that the CO2 molecule is ligated to the unsaturated Cu(II) sites in the cage using its Lewis basic oxygen atom via an angular η1…             Converting Ni-loaded biochars into supercapacitors: Implication on the reuse of exhausted carbonaceous sorbents ▶     Yifan Wang, Yue Zhang, Lei Pei et al.     Biochar derived from waste biomass has proven as a promising sorbent for removal of heavy metals from wastewater. However, proper disposal of such a heavy metal-containing …             One-Pot Green Synthesis of Graphene Nanosheets Encapsulated Gold Nanoparticles for Sensitive and Selective Detection of Dopamine ▶     Balamurugan Thirumalraj, Chellakannu Rajkumar, Shen-Ming Chen et al.     We report a simple new approach for green preparation of gallic acid supported reduced graphene oxide encapsulated gold nanoparticles (GA-RGO/AuNPs) via one-pot hydrothermal …             Regioselectivity and Mechanism of Synthesizing N-Substituted 2-Pyridones and 2-Substituted Pyridines via Metal-Free C-O and C-N Bond-Cleaving of Oxazoline[3,2-a]pyridiniums ▶     Bo Li, Susu Xue, Yang Yang et al.     Novel intermediate oxazoline[3,2-a]pyridiniums were facilely prepared from 2-(2,2-dimethoxyethoxy)-pyridines via acid promoted intramolecular cyclization. Sequentially, the …             Erratum: The Synergy of Double Cross-linking Agents on the Properties of Styrene Butadiene Rubber Foams ▶     Liang Shao, Zhan-You Ji, Jian-Zhong Ma et al.                 Catalytic behavior of metal catalysts in high-temperature RWGS reaction: In-situ FT-IR experiments and first-principles calculations ▶     Sungjun Choi, Byoung-In Sang, Jongsup Hong et al.     High-temperature chemical reactions are ubiquitous in (electro) chemical applications designed to meet the growing demands of environmental and energy protection. However, the …             Electronic Structure Evolution with Composition Alteration of RhxCuy Alloy Nanoparticles ▶     Natalia Palina, Osami Sakata, L. S. R. Kumara et al.     The change in electronic structure of extremely small RhxCuy alloy nanoparticles (NPs) with composition variation was investigated by core-level (CL) and valence-band (VB) hard …             A novel Laccase Biosensor based on Laccase immobilized Graphene-Cellulose Microfiber Composite modified Screen-Printed Carbon Electrode for Sensitive Determination of Catechol ▶     Selvakumar Palanisamy, Sayee Kannan Ramaraj, Shen-Ming Chen et al.     In the present work, we demonstrate the fabrication of laccase biosensor to detect the catechol (CC) using laccase immobilized on graphene-cellulose microfibers (GR-CMF) …             Determining the Photoisomerization Quantum Yield of Photoswitchable Molecules in Solution and in the Solid State ▶     K. Stranius, K. Börjesson     Photoswitchable molecules are able to isomerize between two metastable forms through light stimuli. Originally being studied by photochemists, this type of molecule has now found …             Advanced Materials From Fungal Mycelium: Fabrication and Tuning of Physical Properties ▶     Muhammad Haneef, Luca Ceseracciu, Claudio Canale et al.     In this work is presented a new category of self-growing, fibrous, natural composite materials with controlled physical properties that can be produced in large quantities and …             Towards accurate quantum simulations of large systems with small computers ▶     Yonggang Yang     Numerical simulations are important for many systems. In particular, various standard computer programs have been developed for solving the quantum Schrödinger equations. …             CuMnOS Nanoflowers with Different Cu+/Cu2+ Ratios for the CO2-to-CH3OH and the CH3OH-to-H2 Redox Reactions ▶     Xiaoyun Chen, Hairus Abdullah, Dong-Hau Kuo     A conservative CO2-Methanol (CH3OH) regeneration cycle, to capture and reutilize the greenhouse gas of CO2 by aqueous hydrogenation for industry-useful CH3OH and to convert …                 Physical Sciences ▲ top               A robust, highly stretchable supramolecular polymer conductive hydrogel with self-healability and thermo-processability ▶     Qian Wu, Junjie Wei, Bing Xu et al.     Dual amide hydrogen bond crosslinked and strengthened high strength supramolecular polymer conductive hydrogels were fabricated by simply in situ doping poly (N-acryloyl …             Effect of LPSO and SFs on microstructure evolution and mechanical properties of Mg-Gd-Y-Zn-Zr alloy ▶     Chao Xu, Taiki Nakata, Xiaoguang Qiao et al.     High performance Mg-8.2Gd-3.8Y-1.0Zn-0.4Zr alloy with high strength and excellent ductility has been successfully developed by hot extrusion. The effect of plate-shaped long …             Constructing Robust Cooperative Networks using a Multi-Objective Evolutionary Algorithm ▶     Shuai Wang, Jing Liu     The design and construction of network structures oriented towards different applications has attracted much attention recently. The existing studies indicated that structural …             Discorrelated quantum states ▶     Evan Meyer-Scott, Johannes Tiedau, Georg Harder et al.     The statistical properties of photons are fundamental to investigating quantum mechanical phenomena using light. In multiphoton, two-mode systems, correlations may exist between …             Exciton Emission Intensity Modulation of Monolayer MoS2 via Au Plasmon Coupling ▶     B. Mukherjee, N. Kaushik, Ravi P. N. Tripathi et al.     Modulation of photoluminescence of atomically thin transition metal dichalcogenide two-dimensional materials is critical for their integration in optoelectronic and photonic …             Effects of light on quantum phases and topological properties of two-dimensional Metal-organic frameworks ▶     Yunhua Wang, Yulan Liu, Biao Wang     Periodically driven nontrivial quantum states open another door to engineer topological phases in solid systems by light. Here we show, based on the Floquet-Bloch theory, that …             Composition dependent band offsets of ZnO and its ternary alloys ▶     Haitao Yin, Junli Chen, Yin Wang et al.     We report the calculated fundamental band gaps of wurtzite ternary alloys Zn1−xMxO (M = Mg, Cd) and the band offsets of the ZnO/Zn1−xMxO heterojunctions, these II-VI materials …             Three-dimensional ordered mesoporous Co3O4 enhanced by Pd for oxygen evolution reaction ▶     Qing Qu, Jian-Hua Zhang, Jing Wang et al.     Considerable efforts have been devoted recently to design and fabrication of high performance and low cost electrocatalysts for oxygen evolution reaction (OER). However, …             Wide Field-of-view and Broadband Terahertz Beam Steering Based on Gap Plasmon Geodesic Antennas ▶     Kaipeng Liu, Yinghui Guo, Mingbo Pu et al.     Despite a plethora of applications ranging from wireless communications to sensing and spectroscopy, the current terahertz beam steering technologies suffer from tremendous …             Hydrocracking of Jatropha Oil over non-sulfided PTA-NiMo/ZSM-5 Catalyst ▶     Xiaosong Yang, Jing Liu, Kai Fan et al.     The PTA-NiMo/ZSM-5 catalyst impregnated with phosphotungstic acid (PTA) was designed for the transformation of Jatropha oil into benzene, toluene, and xylenes (BTX) aromatics. …             Time-reversing a monochromatic subwavelength optical focus by optical phase conjugation of multiply-scattered light ▶     Jongchan Park, Chunghyun Park, KyeoReh Lee et al.     Due to its time-reversal nature, optical phase conjugation generates a monochromatic light wave which retraces its propagation paths. Here, we demonstrate the regeneration of a …             Determination and controlling of grain structure of metals after laser incidence: Theoretical approach ▶     Amir Reza Ansari Dezfoli, Weng-Sing Hwang, Wei-Chin Huang et al.     There are serious questions about the grain structure of metals after laser melting and the ways that it can be controlled. In this regard, the current paper explains the grain …             Poly(carboxylate ether)-based superplasticizer achieves workability retention in calcium aluminate cement ▶     Omid Akhlaghi, Yusuf Ziya Menceloglu, Ozge Akbulut     Calcium aluminate cement (CAC) suffers from loss of workability in less than an hour (~15 minutes) after first touch of water. Current superplasticizers that are utilized to …             Spatial Division Multiplexed Microwave Signal processing by selective grating inscription in homogeneous multicore fibers ▶     Ivana Gasulla, David Barrera, Javier Hervás et al.     The use of Spatial Division Multiplexing for Microwave Photonics signal processing is proposed and experimentally demonstrated, for the first time to our knowledge, based on the …             Key factors affecting mechanical behavior of metallic glass nanowires ▶     Qi Zhang, Qi-Kai Li, Mo Li     Both strengthening and weakening trends with decreasing diameter have been observed for metallic glass nanowires, sometimes even in the samples with the same chemical …             Chaoticons described by nonlocal nonlinear Schrödinger equation ▶     Lanhua Zhong, Yuqi Li, Yong Chen et al.     It is shown that the unstable evolutions of the Hermite-Gauss-type stationary solutions for the nonlocal nonlinear Schrödinger equation with the exponential-decay response …             Solar-Pumping Upconversion of Interfacial Coordination Nanoparticles ▶     Ayumi Ishii, Miki Hasegawa     An interfacial coordination nanoparticle successfully exhibited an upconversion blue emission excited by very low-power light irradiation, such as sunlight. The interfacial …             Critical scattering and incommensurate phase transition in antiferroelectric PbZrO3 under pressure ▶     R. G. Burkovsky, I. Bronwald, D. Andronikova et al.     Antiferroelectric lead zirconate is the key ingredient in modern ferroelectric and piezoelectric functional solid solutions. By itself it offers opportunities in new-type …             Mode Coupling and Nonlinear Resonances of MEMS Arch Resonators for Bandpass Filters ▶     Amal Z. Hajjaj, Md Abdullah Hafiz, Mohammad I. Younis     We experimentally demonstrate an exploitation of the nonlinear softening, hardening, and veering phenomena (near crossing), where the frequencies of two vibration modes get close …             Magnetocaloric effect and negative thermal expansion in hexagonal Fe doped MnNiGe compounds with a magnetoelastic AFM-FM-like transition ▶     Kun Xu, Zhe Li, Enke Liu et al.     We report a detailed study of two successive first-order transitions, including a martensitic transition (MT) and an antiferromagnetic (AFM)-ferromagnetic (FM)-like transition, …             Signal mingle: Micropatterns of BMP-2 and fibronectin on soft biopolymeric films regulate myoblast shape and SMAD signaling ▶     Vincent Fitzpatrick, Laure Fourel, Olivier Destaing et al.     In vivo, bone morphogenetic protein 2 (BMP-2) exists both in solution and bound to the extracellular matrix (ECM). While these two modes of presentation are known to influence …             Guided magnonic Michelson interferometer ▶     Muhammad H. Ahmed, Jan Jeske, Andrew D. Greentree     Magnonics is an emerging field with potential applications in classical and quantum information processing. Freely propagating magnons in two-dimensional media are subject to …             Emergence of consensus as a modular-to-nested transition in communication dynamics ▶     Javier Borge-Holthoefer, Raquel A. Baños, Carlos Gracia-Lázaro et al.     Online social networks have transformed the way in which humans communicate and interact, leading to a new information ecosystem where people send and receive information through …             The dynamic behaviors of complementary correlations under decoherence channels ▶     Ming-Ming Du, Dong Wang, Liu Ye     Complementary correlations can reveal the genuine quantum correlations present in a composite quantum system. Here, we explore an effective method to identify the entangled Bell …             Comparison between Field Effect Transistors and Bipolar Junction Transistors as Transducers in Electrochemical Sensors ▶     Sufi Zafar, Minhua Lu, Ashish Jagtiani     Field effect transistors (FET) have been widely used as transducers in electrochemical sensors for over 40 years. In this report, a FET transducer is compared with the recently …             Hollow Au-Ag Nanoparticles Labeled Immunochromatography Strip for Highly Sensitive Detection of Clenbuterol ▶     Jingyun Wang, Lei Zhang, Youju Huang et al.     The probe materials play a significant role in improving the detection efficiency and sensitivity of lateral-flow immunochromatographic test strip (ICTS). Unlike conventional …             Ultrafiltration membrane for effective removal of chromium ions from potable water ▶     M. R. Muthumareeswaran, Mansour Alhoshan, Gopal Prasad Agarwal     The objective of the present work was to investigate the efficacy of indigenously developed polyacrylonitrile (PAN) based ultrafiltration (UF) membrane for chromium ions removal …             Quantum Interference and Selectivity through Biological Ion Channels ▶     Vahid Salari, Hamidreza Naeij, Afshin Shafiee     The mechanism of selectivity in ion channels is still an open question in biology for more than half a century. Here, we suggest that quantum interference can be a solution to …             DOE Optimization of Nano-based Carrier of Pregabalin as Hydrogel: New Therapeutic & Chemometric Approaches for Controlled Drug Delivery Systems ▶     Mona G. Arafa, Bassam M. Ayoub     Niosomes entrapping pregabalin (PG) were prepared using span 60 and cholesterol in different molar ratios by hydration method, the remaining PG from the hydrating solution was …             A glasses-type wearable device for monitoring the patterns of food intake and facial activity ▶     Jungman Chung, Jungmin Chung, Wonjun Oh et al.     Here we present a new method for automatic and objective monitoring of ingestive behaviors in comparison with other facial activities through load cells embedded in a pair of …             Ultra-fast cell counters based on microtubular waveguides ▶     Cornelius S. Bausch, Christian Heyn, Wolfgang Hansen et al.     We present a radio-frequency impedance-based biosensor embedded inside a semiconductor microtube for the in-flow detection of single cells. An impedance-matched tank circuit and …             A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency ▶     Arun Kumar Tharkeshwar, Jesse Trekker, Wendy Vermeire et al.     Superparamagnetic iron oxide nanoparticles (SPIONs) have mainly been used as cellular carriers for genes and therapeutic products, while their use in subcellular organelle …             Ultrafast nonlinear optical properties of thin-solid DNA film and their application as a saturable absorber in femtosecond mode-locked fiber laser ▶     Reza Khazaeinezhad, Sahar Hosseinzadeh Kassani, Bjorn Paulson et al.     A new extraordinary application of deoxyribonucleic acid (DNA) thin-solid-film was experimentally explored in the field of ultrafast nonlinear photonics. Optical transmission was …             Hexagonal tungsten oxide nanoflowers as enzymatic mimetics and electrocatalysts ▶     Chan Yeong Park, Ji Min Seo, Hongil Jo et al.     Tungsten oxide (WOx) has been widely studied for versatile applications based on its photocatalytic, intrinsic catalytic, and electrocatalytic properties. Among the several …             Efficient single-pixel multispectral imaging via non-mechanical spatio-spectral modulation ▶     Ziwei Li, Jinli Suo, Xuemei Hu et al.     Combining spectral imaging with compressive sensing (CS) enables efficient data acquisition by fully utilizing the intrinsic redundancies in natural images. Current compressive …             On the Fractality of Complex Networks: Covering Problem, Algorithms and Ahlfors Regularity ▶     Lihong Wang, Qin Wang, Lifeng Xi et al.     In this paper, we revisit the fractality of complex network by investigating three dimensions with respect to minimum box-covering, minimum ball-covering and average volume of …             Thermally induced gas flows in ratchet channels with diffuse and specular boundaries ▶     Vahid Shahabi, Tobias Baier, Ehsan Roohi et al.     A net gas flow can be induced in the gap between periodically structured surfaces held at fixed but different temperatures when the reflection symmetry along the channel axis is …             Emergent Properties of Giant Vesicles Formed by a Polymerization-Induced Self-Assembly (PISA) Reaction ▶     Anders N. Albertsen, Jan K. Szymański, Juan Pérez-Mercader     Giant micrometer sized vesicles are of obvious interest to the natural sciences as well as engineering, having potential application in fields ranging from drug delivery to …             Graphene Oxide Dysregulates Neuroligin/NLG-1-Mediated Molecular Signaling in Interneurons in Caenorhabditis elegans ▶     He Chen, Huirong Li, Dayong Wang     Graphene oxide (GO) can be potentially used in many medical and industrial fields. Using assay system of Caenorhabditis elegans, we identified the NLG-1/Neuroligin-mediated …             Temperature dependent CO2 behavior in microporous 1-D channels of a metal-organic framework with multiple interaction sites ▶     Dongwook Kim, Jaehun Park, Yung Sam Kim et al.     The MOF with the encapsulated CO2 molecule shows that the CO2 molecule is ligated to the unsaturated Cu(II) sites in the cage using its Lewis basic oxygen atom via an angular η1…             Effect of the KF post-deposition treatment on grain boundary properties in Cu(In, Ga)Se2 thin films ▶     N. Nicoara, Th. Lepetit, L. Arzel et al.     Significant power conversion efficiency improvements have recently been achieved for thin-film solar cells based on a variety of polycrystalline absorbers, including perovskites, …             One-Pot Green Synthesis of Graphene Nanosheets Encapsulated Gold Nanoparticles for Sensitive and Selective Detection of Dopamine ▶     Balamurugan Thirumalraj, Chellakannu Rajkumar, Shen-Ming Chen et al.     We report a simple new approach for green preparation of gallic acid supported reduced graphene oxide encapsulated gold nanoparticles (GA-RGO/AuNPs) via one-pot hydrothermal …             Highly Flexible and Transparent Ag Nanowire Electrode Encapsulated with Ultra-Thin Al2O3: Thermal, Ambient, and Mechanical Stabilities ▶     Byungil Hwang, Youngseo An, Hyangsook Lee et al.     There is an increasing demand in the flexible electronics industry for highly robust flexible/transparent conductors that can withstand high temperatures and corrosive …             Effects of non-exciton components excited by broadband pulses on quantum beats in a GaAs/AlAs multiple quantum well ▶     Osamu Kojima, Yuki Iwasaki, Takashi Kita et al.     In this study, we report the effect of the excitation of non-exciton components caused by broadband pulses on quantum beat oscillation. Using a spectrally controlled pump pulse, …             Effect of Flow and Particle-Plastron Collision on the Longevity of Superhydrophobicity ▶     Babak Vajdi Hokmabad, Sina Ghaemi     Among diverse methods for drag reduction, superhydrophobicity has shown considerable promise because it can produce a shear-free boundary without energy input. However, the …             Hazy Transparent Cellulose Nanopaper ▶     Ming-Chun Hsieh, Hirotaka Koga, Katsuaki Suganuma et al.     The aim of this study is to clarify light scattering mechanism of hazy transparent cellulose nanopaper. Clear optical transparent nanopaper consists of 3–15 nm wide cellulose …             A Circular Polarizer with Beamforming Feature Based on Frequency Selective Surfaces ▶     Jia Yuan Yin, Xiang Wan, Jian Ren et al.     We propose a circular polarizer with beamforming features based on frequency selective surface (FSS), in which a modified anchor-shaped unit cell is used to reach the circular …             Converting Ni-loaded biochars into supercapacitors: Implication on the reuse of exhausted carbonaceous sorbents ▶     Yifan Wang, Yue Zhang, Lei Pei et al.     Biochar derived from waste biomass has proven as a promising sorbent for removal of heavy metals from wastewater. However, proper disposal of such a heavy metal-containing …             Mastoid vibration affects dynamic postural control during gait in healthy older adults ▶     Jung Hung Chien, Mukul Mukherjee, Jenny Kent et al.     Vestibular disorders are difficult to diagnose early due to the lack of a systematic assessment. Our previous work has developed a reliable experimental design and the result …             Fabrication, Optimization and Characterization of Natural Dye Sensitized Solar Cell ▶     William Ghann, Hyeonggon Kang, Tajbik Sheikh et al.     The dyes extracted from pomegranate and berry fruits were successfully used in the fabrication of natural dye sensitized solar cells (NDSSC). The morphology, porosity, surface …             Augmented laminography, a correlative 3D imaging method for revealing the inner structure of compressed fossils ▶     Marcus Zuber, Michael Laaß, Elias Hamann et al.     Non-destructive imaging techniques can be extremely useful tools for the investigation and the assessment of palaeontological objects, as mechanical preparation of rare and …             RhBMP-2 loaded 3D-printed mesoporous silica/calcium phosphate cement porous scaffolds with enhanced vascularization and osteogenesis properties ▶     Cuidi Li, Chuan Jiang, Yuan Deng et al.     A major limitation in the development of effective scaffolds for bone regeneration has been the limited vascularization of the regenerating tissue. Here, we propose the …             Head rice rate measurement based on concave point matching ▶     Yuan Yao, Wei Wu, Tianle Yang et al.     Head rice rate is an important factor affecting rice quality. In this study, an inflection point detection-based technology was applied to measure the head rice rate by combining …             Preprocedural C-Reactive Protein Predicts Outcomes after Primary Percutaneous Coronary Intervention in Patients with ST-elevation Myocardial Infarction a systematic meta-analysis ▶     Raluca-Ileana Mincu, Rolf Alexander Jánosi, Dragos Vinereanu et al.     Risk assessment in patients with acute coronary syndromes (ACS) is critical in order to provide adequate treatment. We performed a systematic meta-analysis to assess the …             Design and fabrication of a passive droplet dispenser for portable high resolution imaging system ▶     Tahseen Kamal, Rachel Watkins, Zijian Cen et al.     Moldless lens manufacturing techniques using standard droplet dispensing technology often require precise control over pressure to initiate fluid flow and control droplet …             Distinguishing Functional DNA Words; A Method for Measuring Clustering Levels ▶     Hanieh Moghaddasi, Khosrow Khalifeh, Amir Hossein Darooneh     Functional DNA sub-sequences and genome elements are spatially clustered through the genome just as keywords in literary texts. Therefore, some of the methods for ranking words …             Photodegradation of octylisothiazolinone and semi-field emissions from facade coatings ▶     Ulla E. Bollmann, Greta Minelgaite, Michael Schlüsener et al.     Amongst others, 2-octyl-isothiazol-3(2 H)-one (OIT) is used as film preservative in water-based polymer resin paints and renders to prevent the growth of moulds and bacteria. It …             Catalytic behavior of metal catalysts in high-temperature RWGS reaction: In-situ FT-IR experiments and first-principles calculations ▶     Sungjun Choi, Byoung-In Sang, Jongsup Hong et al.     High-temperature chemical reactions are ubiquitous in (electro) chemical applications designed to meet the growing demands of environmental and energy protection. However, the …             Thermal conductivity of graphene nanoribbons under shear deformation: A molecular dynamics simulation ▶     Chao Zhang, Xiao-Li Hao, Cui-Xia Wang et al.     Tensile strain and compress strain can greatly affect the thermal conductivity of graphene nanoribbons (GNRs). However, the effect of GNRs under shear strain, which is also one …             Regioselectivity and Mechanism of Synthesizing N-Substituted 2-Pyridones and 2-Substituted Pyridines via Metal-Free C-O and C-N Bond-Cleaving of Oxazoline[3,2-a]pyridiniums ▶     Bo Li, Susu Xue, Yang Yang et al.     Novel intermediate oxazoline[3,2-a]pyridiniums were facilely prepared from 2-(2,2-dimethoxyethoxy)-pyridines via acid promoted intramolecular cyclization. Sequentially, the …             Sb2O3/Ag/Sb2O3 Multilayer Transparent Conducting Films For Ultraviolet Organic Light-emitting Diode ▶     Chunyan Song, Nan Zhang, Jie Lin et al.     A novel UV transparent conducting films based on Sb2O3/Ag/Sb2O3 (SAS) structure, which were prepared by an electron-beam thermal evaporation at room temperature. This SAS …             Spatial distribution of electrons near the Fermi level in the metallic LaB6 through accurate X-ray charge density study ▶     Hidetaka Kasai, Eiji Nishibori     Charge densities of iso-structural metal hexaborides, a transparent metal LaB6 and a semiconductor BaB6, have been determined using the d > 0.22 Å ultra-high resolution …             Soft Nanocomposite Based Multi-point, Multi-directional Strain Mapping Sensor Using Anisotropic Electrical Impedance Tomography ▶     Hyosang Lee, Donguk Kwon, Haedo Cho et al.     The practical utilization of soft nanocomposites as a strain mapping sensor in tactile sensors and artificial skins requires robustness for various contact conditions as well as …             Erratum: The Synergy of Double Cross-linking Agents on the Properties of Styrene Butadiene Rubber Foams ▶     Liang Shao, Zhan-You Ji, Jian-Zhong Ma et al.                 Six-band terahertz metamaterial absorber based on the combination of multiple-order responses of metallic patches in a dual-layer stacked resonance structure ▶     Ben-Xin Wang, Gui-Zhen Wang, Tian Sang et al.     This paper reports on a numerical study of the six-band metamaterial absorber composed of two alternating stack of metallic-dielectric layers on top of a continuous metallic …             Using electric current to surpass the microstructure breakup limit ▶     Rongshan Qin     The elongated droplets and grains can break up into smaller ones. This process is driven by the interfacial free energy minimization, which gives rise to a breakup limit. We …             Noise-tunable nonlinearity in a dispersively coupled diffusion-resonator system using superconducting circuits ▶     Christin Rhén, Andreas Isacsson     The harmonic oscillator is one of the most widely used model systems in physics: an indispensable theoretical tool in a variety of fields. It is well known that an otherwise …             Integrated Microfluidic Flow-Through Microbial Fuel Cells ▶     Huawei Jiang, Md. Azahar Ali, Zhen Xu et al.     This paper reports on a miniaturized microbial fuel cell with a microfluidic flow-through configuration: a porous anolyte chamber is formed by filling a microfluidic chamber with …             Electronic Structure Evolution with Composition Alteration of RhxCuy Alloy Nanoparticles ▶     Natalia Palina, Osami Sakata, L. S. R. Kumara et al.     The change in electronic structure of extremely small RhxCuy alloy nanoparticles (NPs) with composition variation was investigated by core-level (CL) and valence-band (VB) hard …             Broadband Energy Harvester Using Non-linear Polymer Spring and Electromagnetic/Triboelectric Hybrid Mechanism ▶     Rahul Kumar Gupta, Qiongfeng Shi, Lokesh Dhakar et al.     Over the years, several approaches have been devised to widen the operating bandwidth, but most of them can only be triggered at high accelerations. In this work, we investigate …             Syringeless Electrospinning toward Versatile Fabrication of Nanofiber Web ▶     Seongjun Moon, Manjae Gil, Kyung Jin Lee     Although electrospinning is considered a powerful and generic tool for the preparation of nanofiber webs, several issues still need to be overcome for real-world applications. …             Escape rate and diffusion of a Stochastically Driven particle ▶     Antonio Piscitelli, Massimo Pica Ciamarra     The dynamical properties of a tracer repeatedly colliding with heat bath particles can be described within a Langevin framework provided that the tracer is more massive than the …             Alignment Solution for CT Image Reconstruction using Fixed Point and Virtual Rotation Axis ▶     Kyungtaek Jun, Seokhwan Yoon     Since X-ray tomography is now widely adopted in many different areas, it becomes more crucial to find a robust routine of handling tomographic data to get better quality of …             Excellent Thermoelectric Properties in monolayer WSe2 Nanoribbons due to Ultralow Phonon Thermal Conductivity ▶     Jue Wang, Fang Xie, Xuan-Hao Cao et al.     By using first-principles calculations combined with the nonequilibrium Green’s function method and phonon Boltzmann transport equation, we systematically investigate the …             Persistence of strong and switchable ferroelectricity despite vacancies ▶     Aldo Raeliarijaona, Huaxiang Fu     Vacancies play a pivotal role in affecting ferroelectric polarization and switching properties, and there is a possibility that ferroelectricity may be utterly eliminated when …             Antimicrobial Nanoplexes meet Model Bacterial Membranes: the key role of Cardiolipin ▶     Alejandro Marín-Menéndez, Costanza Montis, Teresa Díaz-Calvo et al.     Antimicrobial resistance to traditional antibiotics is a crucial challenge of medical research. Oligonucleotide therapeutics, such as antisense or Transcription Factor Decoys …             Physical Activity, TV Watching Time, Sleeping, and Risk of Obesity and Hyperglycemia in the Offspring of Mothers with Gestational Diabetes Mellitus ▶     Tao Zhang, Peng Wang, Huikun Liu et al.     We investigated the association of physical activity, TV watching time, sleeping time with the risks of obesity and hyperglycemia among 1263 offspring aged 1–5 years of mothers …             A New Efficient Hybrid Intelligent Model for Biodegradation Process of DMP with Fuzzy Wavelet Neural Networks ▶     Mingzhi Huang, Tao Zhang, Jujun Ruan et al.     A new efficient hybrid intelligent approach based on fuzzy wavelet neural network (FWNN) was proposed for effectively modeling and simulating biodegradation process of Dimethyl …             Kernel-based Joint Feature Selection and Max-Margin Classification for Early Diagnosis of Parkinson’s Disease ▶     Ehsan Adeli, Guorong Wu, Behrouz Saghafi et al.     Feature selection methods usually select the most compact and relevant set of features based on their contribution to a linear regression model. Thus, these features might not be …             A deforestation-induced tipping point for the South American monsoon system ▶     Niklas Boers, Norbert Marwan, Henrique M. J. Barbosa et al.     The Amazon rainforest has been proposed as a tipping element of the earth system, with the possibility of a dieback of the entire ecosystem due to deforestation only of parts of …             Dynamical proxies of North Atlantic predictability and extremes ▶     Davide Faranda, Gabriele Messori, Pascal Yiou     Atmospheric flows are characterized by chaotic dynamics and recurring large-scale patterns. These two characteristics point to the existence of an atmospheric attractor defined …             Unloading Characteristics of Sand-drift in Wind-shallow Areas along Railway and the Effect of Sand Removal by Force of Wind ▶     Jian-jun Cheng, Guo-Wei Xin, Ling-yan Zhi et al.     Wind-shield walls decrease the velocity of wind-drift sand flow in transit. This results in sand accumulating in the wind-shadow zone of both windshield wall and track line, …             High Quality Bioreplication of Intricate Nanostructures from a Fragile Gecko Skin Surface with Bactericidal Properties ▶     David William Green, Kenneth Ka-Ho Lee, Jolanta Anna Watson et al.     The external epithelial surfaces of plants and animals are frequently carpeted with small micro- and nanostructures, which broadens their adaptive capabilities in challenging …             Optimal Down Regulation of mRNA Translation ▶     Yoram Zarai, Michael Margaliot, Tamir Tuller     Down regulation of mRNA translation is an important problem in various bio-medical domains ranging from developing effective medicines for tumors and for viral diseases to …             Mechanistic insights into the impact of Cold Atmospheric Pressure Plasma on human epithelial cell lines ▶     Marlène Dezest, Laurent Chavatte, Marion Bourdens et al.     Compelling evidence suggests that Cold Atmospheric Pressure Plasma (CAPP) has potential as a new cancer therapy. However, knowledge about cellular signaling events and toxicity …             CuMnOS Nanoflowers with Different Cu+/Cu2+ Ratios for the CO2-to-CH3OH and the CH3OH-to-H2 Redox Reactions ▶     Xiaoyun Chen, Hairus Abdullah, Dong-Hau Kuo     A conservative CO2-Methanol (CH3OH) regeneration cycle, to capture and reutilize the greenhouse gas of CO2 by aqueous hydrogenation for industry-useful CH3OH and to convert …             Holographic image generation with a thin-film resonance caused by chalcogenide phase-change material ▶     Seung-Yeol Lee, Yong-Hae Kim, Seong-M. Cho et al.     The development of digital holography is anticipated for the viewing of 3D images by reconstructing both the amplitude and phase information of the object. Compared to analog …             Giant Flexoelectro-optic Effect with Liquid Crystal Dimer CB7CB ▶     Andrii Varanytsia, Liang-Chy Chien     We demonstrate a giant flexoelectro-optic behavior of liquid crystal dimer CB7CB. Flexoelectric properties of CB7CB experimentally characterized by measured angle of an in-plane …             A novel Laccase Biosensor based on Laccase immobilized Graphene-Cellulose Microfiber Composite modified Screen-Printed Carbon Electrode for Sensitive Determination of Catechol ▶     Selvakumar Palanisamy, Sayee Kannan Ramaraj, Shen-Ming Chen et al.     In the present work, we demonstrate the fabrication of laccase biosensor to detect the catechol (CC) using laccase immobilized on graphene-cellulose microfibers (GR-CMF) …             Model dielectric function for 2D semiconductors including substrate screening ▶     Mads L. Trolle, Thomas G. Pedersen, Valerie Véniard     Dielectric screening of excitons in 2D semiconductors is known to be a highly non-local effect, which in reciprocal space translates to a strong dependence on momentum transfer q…             Design of Hierarchical Structures for Synchronized Deformations ▶     Hamed Seifi, Anooshe Rezaee Javan, Arash Ghaedizadeh et al.     In this paper we propose a general method for creating a new type of hierarchical structures at any level in both 2D and 3D. A simple rule based on a rotate-and-mirror procedure …             Towards accurate quantum simulations of large systems with small computers ▶     Yonggang Yang     Numerical simulations are important for many systems. In particular, various standard computer programs have been developed for solving the quantum Schrödinger equations. …             Advanced Materials From Fungal Mycelium: Fabrication and Tuning of Physical Properties ▶     Muhammad Haneef, Luca Ceseracciu, Claudio Canale et al.     In this work is presented a new category of self-growing, fibrous, natural composite materials with controlled physical properties that can be produced in large quantities and …             Determining the Photoisomerization Quantum Yield of Photoswitchable Molecules in Solution and in the Solid State ▶     K. Stranius, K. Börjesson     Photoswitchable molecules are able to isomerize between two metastable forms through light stimuli. Originally being studied by photochemists, this type of molecule has now found …             UV and visible light photocatalytic activity of Au/TiO2 nanoforests with Anatase/Rutile phase junctions and controlled Au locations ▶     Yang Yu, Wei Wen, Xin-Yue Qian et al.     To magnify anatase/rutile phase junction effects through appropriate Au decorations, a facile solution-based approach was developed to synthesize Au/TiO2 nanoforests with …             A Rechargeable Li-Air Fuel Cell Battery Based on Garnet Solid Electrolytes ▶     Jiyang Sun, Ning Zhao, Yiqiu Li et al.     Non-aqueous Li-air batteries have been intensively studied in the past few years for their theoretically super-high energy density. However, they cannot operate properly in real …             Effects of ultrasonic vibration on the microstructure and mechanical properties of high alloying TiAl ▶     Chen Ruirun, Zheng Deshuang, Ma Tengfei et al.     To modify the microstructure and enhance performances, the ultrasonic vibration is applied in the mould casting of TiAl alloy. The effects and mechanism of ultrasonic vibration …             Charge transport in nanoscale vertical organic semiconductor pillar devices ▶     Janine G. E. Wilbers, Bojian Xu, Peter A. Bobbert et al.     We report charge transport measurements in nanoscale vertical pillar structures incorporating ultrathin layers of the organic semiconductor poly(3-hexylthiophene) (P3HT). P3HT …             Interacting ultracold atomic kicked rotors: loss of dynamical localization ▶     Pinquan Qin, Alexei Andreanov, Hee Chul Park et al.     We study the fate of dynamical localization of two quantum kicked rotors with contact interaction, which relates to experimental realizations of the rotors with ultra-cold atomic …             Hybrid fiber resonator employing LRSPP waveguide coupler for gyroscope ▶     Guang Qian, Xing-Chang Fu, Li-Jiang Zhang et al.     Polarization error and temperature noise are two main limits to the performance of resonant fiber optic gyroscope (RFOG). To overcome these limits, we demonstrated a hybrid …             Fundamental mechanism for all-optical helicity-dependent switching of magnetization ▶     Xiang-Jun Chen     Switching magnetizations with femtosecond circularly polarized lasers may have revolutionary impacts on magnetic data storage and relevant applications. Achievements in …             Iterative Neighbour-Information Gathering for Ranking Nodes in Complex Networks ▶     Shuang Xu, Pei Wang, Jinhu Lü     Designing node influence ranking algorithms can provide insights into network dynamics, functions and structures. Increasingly evidences reveal that node’s spreading ability …             Focusing and alignment of erythrocytes in a viscoelastic medium ▶     Taesik Go, Hyeokjun Byeon, Sang Joon Lee     Viscoelastic fluid flow-induced cross-streamline migration has recently received considerable attention because this process provides simple focusing and alignment over a wide …             The relationship between vacuolation and initiation of PCD in rice (Oryza sativa) aleurone cells ▶     Yan Zheng, Heting Zhang, Xiaojiang Deng et al.     Vacuole fusion is a necessary process for the establishment of a large central vacuole, which is the central location of various hydrolytic enzymes and other factors involved in …               Earth & Environmental Sciences ▲ top               Tree cover in Central Africa: determinants and sensitivity under contrasted scenarios of global change ▶     Julie C. Aleman, Olivier Blarquez, Sylvie Gourlet-Fleury et al.     Tree cover is a key variable for ecosystem functioning, and is widely used to study tropical ecosystems. But its determinants and their relative importance are still a matter of …             Asymmetric response of tropical cyclone activity to global warming over the North Atlantic and western North Pacific from CMIP5 model projections ▶     Doo-Sun R. Park, Chang-Hoi Ho, Johnny C. L. Chan et al.     Recent improvements in the theoretical understanding of the relationship between tropical cyclones (TCs) and their large-scale environments have resulted in significant …             Collapse of the tropical and subtropical North Atlantic CO2 sink in boreal spring of 2010 ▶     J. Severino P. Ibánhez, Manuel Flores, Nathalie Lefèvre     Following the 2009 Pacific El Niño, a warm event developed in the tropical and subtropical North Atlantic during boreal spring of 2010 promoted a significant increase in the CO2 …             Mixed forest plantations can efficiently filter rainfall deposits of sulfur and chlorine in Western China ▶     Hairong Zhao, Wanqin Yang, Fuzhong Wu et al.     Forest filtering is a well-known and efficient method for diminishing atmospheric pollutant (such as SO42− and Cl−) inputs to soil and water; however, the filtering efficiencies …             Enhanced vapor transport in membrane distillation via functionalized carbon nanotubes anchored into electrospun nanofibres ▶     Alicia Kyoungjin An, Eui-Jong Lee, Jiaxin Guo et al.     To ascertain membrane distillation (MD) as an emerging desalination technology to meet the global water challenge, development of membranes with ideal material properties is …             Analyzing historical land use changes using a Historical Land Use Reconstruction Model: a case study in Zhenlai County, northeastern China ▶     Yuanyuan Yang, Shuwen Zhang, Yansui Liu et al.     Historical land use information is essential to understanding the impact of anthropogenic modification of land use/cover on the temporal dynamics of environmental and ecological …             Conversion from long-term cultivated wheat field to Jerusalem artichoke plantation changed soil fungal communities ▶     Xingang Zhou, Jianhui Zhang, Danmei Gao et al.     Understanding soil microbial communities in agroecosystems has the potential to contribute to the improvement of agricultural productivity and sustainability. Effects of …             Ultrafiltration membrane for effective removal of chromium ions from potable water ▶     M. R. Muthumareeswaran, Mansour Alhoshan, Gopal Prasad Agarwal     The objective of the present work was to investigate the efficacy of indigenously developed polyacrylonitrile (PAN) based ultrafiltration (UF) membrane for chromium ions removal …             Improved prediction of severe thunderstorms over the Indian Monsoon region using high-resolution soil moisture and temperature initialization ▶     K. K. Osuri, R. Nadimpalli, U. C. Mohanty et al.     The hypothesis that realistic land conditions such as soil moisture/soil temperature (SM/ST) can significantly improve the modeling of mesoscale deep convection is tested over …             Detecting the causality influence of individual meteorological factors on local PM2.5 concentration in the Jing-Jin-Ji region ▶     Ziyue Chen, Jun Cai, Bingbo Gao et al.     Due to complicated interactions in the atmospheric environment, quantifying the influence of individual meteorological factors on local PM2.5 concentration remains challenging. …             Augmented laminography, a correlative 3D imaging method for revealing the inner structure of compressed fossils ▶     Marcus Zuber, Michael Laaß, Elias Hamann et al.     Non-destructive imaging techniques can be extremely useful tools for the investigation and the assessment of palaeontological objects, as mechanical preparation of rare and …             Fabrication, Optimization and Characterization of Natural Dye Sensitized Solar Cell ▶     William Ghann, Hyeonggon Kang, Tajbik Sheikh et al.     The dyes extracted from pomegranate and berry fruits were successfully used in the fabrication of natural dye sensitized solar cells (NDSSC). The morphology, porosity, surface …             Converting Ni-loaded biochars into supercapacitors: Implication on the reuse of exhausted carbonaceous sorbents ▶     Yifan Wang, Yue Zhang, Lei Pei et al.     Biochar derived from waste biomass has proven as a promising sorbent for removal of heavy metals from wastewater. However, proper disposal of such a heavy metal-containing …             Counteracting wetland overgrowth increases breeding and staging bird abundances ▶     Petteri Lehikoinen, Aleksi Lehikoinen, Markku Mikkola-Roos et al.     Human actions have led to loss and degradation of wetlands, impairing their suitability as habitat especially for waterbirds. Such negative effects may be mitigated through …             Photodegradation of octylisothiazolinone and semi-field emissions from facade coatings ▶     Ulla E. Bollmann, Greta Minelgaite, Michael Schlüsener et al.     Amongst others, 2-octyl-isothiazol-3(2 H)-one (OIT) is used as film preservative in water-based polymer resin paints and renders to prevent the growth of moulds and bacteria. It …             Population expansion and individual age affect endoparasite richness and diversity in a recolonising large carnivore population ▶     Ines Lesniak, Ilja Heckmann, Emanuel Heitlinger et al.     The recent recolonisation of the Central European lowland (CEL) by the grey wolf (Canis lupus) provides an excellent opportunity to study the effect of founder events on …             A deforestation-induced tipping point for the South American monsoon system ▶     Niklas Boers, Norbert Marwan, Henrique M. J. Barbosa et al.     The Amazon rainforest has been proposed as a tipping element of the earth system, with the possibility of a dieback of the entire ecosystem due to deforestation only of parts of …             Corrigendum: Metabolic and Dynamic Profiling for Risk Assessment of Fluopyram, a Typical Phenylamide Fungicide Widely Applied in Vegetable Ecosystem ▶     Peng Wei, Yanan Liu, Wenzhuo Li et al.                 ‘Blue Carbon’ and Nutrient Stocks of Salt Marshes at a Temperate Coastal Lagoon (Ria de Aveiro, Portugal) ▶     Ana I. Sousa, Danielle B. Santos, Eduardo Ferreira da Silva et al.     Ria de Aveiro is a mesotidal coastal lagoon with one of the largest continuous salt marshes in Europe. The objective of this work was to assess C, N and P stocks of Spartina …             Extent of Night Warming and Spatially Heterogeneous Cloudiness Differentiate Temporal Trend of Greenness in Mountainous Tropics in the New Century ▶     Mei Yu, Qiong Gao, Chunxiao Gao et al.     Tropical forests have essential functions in global C dynamics but vulnerable to changes in land cover land use (LCLUC) and climate. The tropics of Caribbean are experiencing …             Insight into Generation and Evolution of Sea-Salt Aerosols from Field Measurements in Diversified Marine and Coastal Atmospheres ▶     Limin Feng, Hengqing Shen, Yujiao Zhu et al.     This report focuses on studying generation and/or evolution of sea-salt aerosols (SSA) on basis of measurements in the Northwest Pacific Ocean (NWPO), the marginal seas of China, …             Fencing bodes a rapid collapse of the unique Greater Mara ecosystem ▶     Mette Løvschal, Peder Klith Bøcher, Jeppe Pilgaard et al.     With land privatization and fencing of thousands of hectares of communal grazing areas, East Africa is struggling with one of the most radical cultural and environmental changes …             Unloading Characteristics of Sand-drift in Wind-shallow Areas along Railway and the Effect of Sand Removal by Force of Wind ▶     Jian-jun Cheng, Guo-Wei Xin, Ling-yan Zhi et al.     Wind-shield walls decrease the velocity of wind-drift sand flow in transit. This results in sand accumulating in the wind-shadow zone of both windshield wall and track line, …             Magma reservoir dynamics at Toba caldera, Indonesia, recorded by oxygen isotope zoning in quartz ▶     David A. Budd, Valentin R. Troll, Frances M. Deegan et al.     Quartz is a common phase in high-silica igneous rocks and is resistant to post-eruptive alteration, thus offering a reliable record of magmatic processes in silicic magma …             Long-term and realistic global change manipulations had low impact on diversity of soil biota in temperate heathland ▶     Martin Holmstrup, Christian Damgaard, Inger K. Schmidt et al.     In a dry heathland ecosystem we manipulated temperature (warming), precipitation (drought) and atmospheric concentration of CO2 in a full-factorial experiment in order to …             A New Efficient Hybrid Intelligent Model for Biodegradation Process of DMP with Fuzzy Wavelet Neural Networks ▶     Mingzhi Huang, Tao Zhang, Jujun Ruan et al.     A new efficient hybrid intelligent approach based on fuzzy wavelet neural network (FWNN) was proposed for effectively modeling and simulating biodegradation process of Dimethyl …             Change in microbial community in landfill refuse contaminated with antibiotics facilitates denitrification more than the increase in ARG over long-term ▶     Dong Wu, Guanzhou Chen, Xiaojun Zhang et al.     In this study, the addition of sulfamethazine (SMT) to landfill refuse decreased nitrogen intermediates (e.g. N2O and NO) and dinitrogen (N2) gas fluxes to <0.5 μg-N/kg-refuse·h−1…             Dynamical proxies of North Atlantic predictability and extremes ▶     Davide Faranda, Gabriele Messori, Pascal Yiou     Atmospheric flows are characterized by chaotic dynamics and recurring large-scale patterns. These two characteristics point to the existence of an atmospheric attractor defined …             Broadband Energy Harvester Using Non-linear Polymer Spring and Electromagnetic/Triboelectric Hybrid Mechanism ▶     Rahul Kumar Gupta, Qiongfeng Shi, Lokesh Dhakar et al.     Over the years, several approaches have been devised to widen the operating bandwidth, but most of them can only be triggered at high accelerations. In this work, we investigate …             A 10-year observation of PM2.5-bound nickel in Xi’an, China: Effects of source control on its trend and associated health risks ▶     Hongmei Xu, Steven Sai Hang Ho, Junji Cao et al.     This study presents the first long term (10-year period, 2004–2013) datasets of PM2.5-bound nickel (Ni) concentration obtained from the daily sample in urban of Xi’an, …             Dissolved organic matter uptake by Trichodesmium in the Southwest Pacific ▶     Mar Benavides, Hugo Berthelot, Solange Duhamel et al.     The globally distributed diazotroph Trichodesmium contributes importantly to nitrogen inputs in the oligotrophic oceans. Sites of dissolved organic matter (DOM) accumulation …             Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana ▶     Chang-Bum Jeong, Hye-Min Kang, Min-Chul Lee et al.     Microplastic pollution causes a major concern in the marine environment due to their worldwide distribution, persistence, and adverse effects of these pollutants in the marine …             Differential growth of the northern Tibetan margin: evidence for oblique stepwise rise of the Tibetan Plateau ▶     Fei Wang, Wenbei Shi, Weibin Zhang et al.     Models of how high elevations formed across Tibet predict: (a) the continuous thickening of a “viscous sheet”; (b) time-dependent, oblique stepwise growth; and (c) synchronous …             Increase of the Antarctic Sea Ice Extent is highly significant only in the Ross Sea ▶     Naiming Yuan, Minghu Ding, Josef Ludescher et al.     In the context of global warming, the question of why Antarctic sea ice extent (SIE) has increased is one of the most fundamental unsolved mysteries. Although many mechanisms …               Health Sciences ▲ top               Rapid Sputum Multiplex Detection of the M. tuberculosis Complex (MTBC) and Resistance Mutations for Eight Antibiotics by Nucleotide MALDI-TOF MS ▶     Kang-Yi Su, Bo-Shiun Yan, Hao-Chieh Chiu et al.     The increasing incidence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (MTB) adds further urgency for rapid and multiplex molecular …             Neurophysiological correlates of altered response inhibition in internet gaming disorder and obsessive-compulsive disorder: Perspectives from impulsivity and compulsivity ▶     Minah Kim, Tak Hyung Lee, Jung-Seok Choi et al.     Although internet gaming disorder (IGD) and obsessive-compulsive disorder (OCD) represent opposite ends of the impulsivity and compulsivity dimensions, the two disorders share …             Does von Willebrand factor improve the predictive ability of current risk stratification scores in patients with atrial fibrillation? ▶     Amaya García-Fernández, Vanessa Roldán, José Miguel Rivera-Caravaca et al.     Von Willebrand factor (vWF) is a biomarker of endothelial dysfunction. We investigated its role on prognosis in anticoagulated atrial fibrillation (AF) patients and determined …             IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis ▶     Michelle S. M. A. Damen, Rabia Agca, Suzanne Holewijn et al.     Patients with rheumatoid arthritis (RA) are at higher risk of developing cardiovascular diseases (CVD). Interleukin (IL)-32 has previously been shown to be involved in the …             Carotid Intima-media Thickness and its Association with Conventional Risk Factors in Low-income Adults: A Population-based Cross-Sectional Study in China ▶     Bin Liu, Jingxian Ni, Min Shi et al.     Carotid intima-media thickness (CIMT) is an established predictor of cardiovascular disease and stroke. However, risk factors associated with CIMT remain unclear. Therefore, we …             Impact of small vessel disease in the brain on gait and balance ▶     Daniela Pinter, Stuart J. Ritchie, Fergus Doubal et al.     Gait and balance impairment is highly prevalent in older people. We aimed to assess whether and how single markers of small vessel disease (SVD) or a combination thereof explain …             Treatment Outcomes of Patients with Locally Advanced Synchronous Esophageal and Head/Neck Squamous Cell Carcinoma Receiving Curative Concurrent Chemoradiotherapy ▶     Yen-Hao Chen, Hung-I. Lu, Chih-Yen Chien et al.     The present study investigated clinical outcomes and prognostic factors of patients with locally advanced synchronous esophageal squamous cell carcinoma (ESCC) and head/neck …             A novel HDAC inhibitor, CG200745, inhibits pancreatic cancer cell growth and overcomes gemcitabine resistance ▶     Hee Seung Lee, Soo Been Park, Sun A Kim et al.     Pancreatic cancer is predominantly lethal, and is primarily treated using gemcitabine, with increasing resistance. Therefore, novel agents that increase tumor sensitivity to …             Contributions of age-related alterations of the retinal pigment epithelium and of glia to the AMD-like pathology in OXYS rats ▶     Darya V. Telegina, Oyuna S. Kozhevnikova, Sergey I. Bayborodin et al.     Age-related macular degeneration (AMD) is a major cause of blindness in developed countries, and the molecular pathogenesis of early events of AMD is poorly understood. It is …             Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment ▶     Yugo Kai, Hayato Hikita, Naoki Morishita et al.     Resistance-associated substitutions (RASs) in hepatitis C virus (HCV) appear upon failure of treatment with direct-acting antivirals (DAAs). However, their origin has not been …             Effect of bilirubin concentration on the risk of diabetic complications: A meta-analysis of epidemiologic studies ▶     Bo Zhu, Xiaomei Wu, Yifei Bi et al.     Diabetes can affect many parts of the body and is associated with serious complications. Oxidative stress is a major contributor in the pathogenesis of diabetic complications and …             N-terminal pro-brain natriuretic peptide and cardiovascular or all-cause mortality in the general population: A meta-analysis ▶     Zhaohua Geng, Lan Huang, Mingbao Song et al.     The prognostic role of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the general population remains controversial. We conducted this meta-analysis to investigate the …             Bacterial translocation aggravates CCl4-induced liver cirrhosis by regulating CD4+ T cells in rats ▶     Haiyan Shi, Longxian Lv, Hongcui Cao et al.     Bacterial translocation (BT) is thought to play an important role in the development of liver cirrhosis, but the mechanisms have not been fully explored. This study aims to …             Vitamin D receptor gene FokI but not TaqI, ApaI, BsmI polymorphism is associated with Hashimoto’s thyroiditis: a meta-analysis ▶     Xiaofei Wang, Wenli Cheng, Yu Ma et al.     Four VD receptor (VDR) gene polymorphisms (TaqI, ApaI, FokI and BsmI) have been reported to influence Hashimoto’s thyroiditis (HT) risk. However, individual studies have produced …             Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis ▶     Zuyun Liu, Stephen Burgess, Zhengdong Wang et al.     Observational studies suggest associations of triglyceride levels with longevity and frailty. This study aimed to test whether the associations are causal. We used data from the …             Risk factors of acute kidney injury after orthotopic liver transplantation in China ▶     Yin Zongyi, Li Baifeng, Zou Funian et al.     In this study, we determined the risk factors for acute kidney injury (AKI) following orthotopic liver transplantation (OLT) in China. We collected 5074 donation after cardiac …             Prevalence and Predictors of Atherogenic Serum Lipoprotein Dyslipidemia in Women with Obstructive Sleep Apnea ▶     Yunyan Xia, Yiqun Fu, Yuyu Wang et al.     Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, no study has focused on dyslipidemia in women with OSA. The aim of this study was to determine the …             CD133+ cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma ▶     Kai Liu, Meijun Hao, Yabo Ouyang et al.     The role of cancer stem cells (CSCs) in inducing the recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains unclear. Here, we found that a …             Establishment and application of a novel isothermal amplification assay for rapid detection of chloroquine resistance (K76T) in Plasmodium falciparum ▶     Madhvi Chahar, Neelima Mishra, Anup Anvikar et al.     Chloroquine (CQ) resistance in Plasmodium falciparum is determined by the mutations in the chloroquine resistance transporter (Pfcrt) gene. The point mutation at codon 76 (K76T), …             Stress Reactivity in Chronic Tinnitus ▶     Linda T. Betz, Andreas Mühlberger, Berthold Langguth et al.     Tinnitus is primarily an auditory symptom. Yet not only patients and clinicians, but also current pathophysiological models relate the onset and maintenance of tinnitus to …             A glasses-type wearable device for monitoring the patterns of food intake and facial activity ▶     Jungman Chung, Jungmin Chung, Wonjun Oh et al.     Here we present a new method for automatic and objective monitoring of ingestive behaviors in comparison with other facial activities through load cells embedded in a pair of …             A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency ▶     Arun Kumar Tharkeshwar, Jesse Trekker, Wendy Vermeire et al.     Superparamagnetic iron oxide nanoparticles (SPIONs) have mainly been used as cellular carriers for genes and therapeutic products, while their use in subcellular organelle …             Litchi seed extracts diminish prostate cancer progression via induction of apoptosis and attenuation of EMT through Akt/GSK-3β signaling ▶     Hongwei Guo, Hua Luo, Hebao Yuan et al.     Litchi (Litchi chinensisSonnnerat, Sapindaceae), known as Chinese Cherry, is a subtropical fruit tree originating from southern China. Litchi seed extracts have diverse …             A UK wide cohort study describing management and outcomes for infants with surgical Necrotising Enterocolitis ▶     Benjamin Allin, Anna-May Long, Amit Gupta et al.     The Royal College of Surgeons have proposed using outcomes from necrotising enterocolitis (NEC) surgery for revalidation of neonatal surgeons. The aim of this study was therefore …             Neutrophil gelatinase-associated lipocalin (NGAL) fails as an early predictor of contrast induced nephropathy in chronic kidney disease (ANTI-CI-AKI study) ▶     Werner Ribitsch, Gernot Schilcher, Franz Quehenberger et al.     The aim of the study was to evaluate the diagnostic accuracy of urinary neutrophil gelatinase- associated lipocalin (uNGAL) in patients with chronic kidney disease (CKD) as an …             Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress ▶     Mohammad Moshahid Khan, Weng-Lang Yang, Max Brenner et al.     Cold-inducible RNA-binding protein (CIRP), released into the circulation during sepsis, causes lung injury via an as yet unknown mechanism. Since endoplasmic reticulum (ER) …             Gd-EOB-DTPA-enhanced MR relaxometry for the detection and staging of liver fibrosis ▶     Michael Haimerl, Kirsten Utpatel, Niklas Verloh et al.     Gd-EOB-DTPA, a liver-specific contrast agent with T1-shortening effects, is routinely used in clinical routine for detection and characterization of focal liver lesions and has …             Evaluation of 10 SLE susceptibility loci in Asian populations, which were initially identified in European populations ▶     Yue-miao Zhang, Xu-jie Zhou, Swapan K. Nath et al.     Ten novel loci have been found to be associated with systemic lupus erythematosus (SLE) susceptibility by a recent genome-wide association study conducted in Europeans. To test …             Effects of Single-Dose Prucalopride on Intestinal Hypomotility in Horses: Preliminary Observations ▶     Fulvio Laus, Margherita Fratini, Emanuele Paggi et al.     Abnormalities of gastrointestinal motility are often a challenge in horses; however, the use of prokinetic drugs in such conditions must be firmly established yet. For this …             Comorbid diseases as risk factors for incident posttraumatic stress disorder (PTSD) in a large community cohort (KCIS no.PSY4) ▶     Jung-Chen Chang, Amy Ming-Fang Yen, Hsiu-Hsi Chen et al.     Nature disasters and terrorist attacks have occurred globally in recent years. Posttraumatic stress disorder (PTSD) has gained increasing attention, but its incidence and …             Six-year changes in the prevalence of obesity and obesity-related diseases in Northeastern China from 2007 to 2013 ▶     Jing Wu, Hongqin Xu, Xiuting He et al.     Obesity and obesity-related diseases are important public health challenges. In this study, we aimed to provide updated trends in the prevalence of these conditions. We conducted …             Association between underweight and tooth loss among Korean adults ▶     In-Seok Song, Kyungdo Han, Jae-Jun Ryu et al.     There is growing interest in the relationship between body mass index and oral health. Previous study showed that being underweight was significantly associated with having lower …             Astaxanthin protects against early burn-wound progression in rats by attenuating oxidative stress-induced inflammation and mitochondria-related apoptosis ▶     Quan Fang, Songxue Guo, Hanlei Zhou et al.     Burn-wound progression can occur in the initial or peri-burn area after a deep burn injury. The stasis zone has a higher risk of deterioration mediated by multiple factors but is …             Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis ▶     Jin Liu, Changwei Lu, Xiaohao Wu et al.     The underlying mechanism of the reduced bone formation during the development of glucocorticoid-induced osteoporosis (GIO) remains unclear. Here, we found that the highly …             Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart ▶     Anne Van Steenbergen, Magali Balteau, Audrey Ginion et al.     Hyperglycemia (HG) stimulates the production of reactive oxygen species in the heart through activation of NADPH oxidase 2 (NOX2). This production is independent of glucose …             Differentially expressed genes and canonical pathway expression in human atherosclerotic plaques – Tampere Vascular Study ▶     Miska Sulkava, Emma Raitoharju, Mari Levula et al.     Cardiovascular diseases due to atherosclerosis are the leading cause of death globally. We aimed to investigate the potentially altered gene and pathway expression in advanced …             Protective effects of recombinant human cytoglobin against chronic alcohol-induced liver disease in vivo and in vitro ▶     Jian Wen, Yongbin Wu, Wei Wei et al.     Alcoholic liver disease (ALD) is an important worldwide public health issue with no satisfying treatment available since now. Here we explore the effects of recombinant human …             Preprocedural C-Reactive Protein Predicts Outcomes after Primary Percutaneous Coronary Intervention in Patients with ST-elevation Myocardial Infarction a systematic meta-analysis ▶     Raluca-Ileana Mincu, Rolf Alexander Jánosi, Dragos Vinereanu et al.     Risk assessment in patients with acute coronary syndromes (ACS) is critical in order to provide adequate treatment. We performed a systematic meta-analysis to assess the …             Prognostic Role of the Pretreatment C-Reactive Protein/Albumin Ratio in Solid Cancers: A Meta-Analysis ▶     Nan Li, Guang-Wei Tian, Ying Wang et al.     The C-reactive protein/albumin ratio (CAR) has been shown to play a significant prognostic role in several cancers. We aimed to comprehensively explore the potential role of the …             Genotyping of human rhinovirus in adult patients with acute respiratory infections identified predominant infections of genotype A21 ▶     Lili Ren, Donghong Yang, Xianwen Ren et al.     Human rhinovirus (HRV) is an important causative agent of acute respiratory tract infections (ARTIs). The roles of specific HRV genotypes in patients suffering from ARTIs have …             Body mass index moderates the relationship between C-reactive protein and depressive symptoms: evidence from the China Health and Retirement Longitudinal Study ▶     Tingting Qin, Wenhua Liu, Minghui Yin et al.     The present study aimed to investigate the role of abnormal body mass index (BMI, kg/m2) in the depression-CRP (C-reactive protein) relationship in a healthy middle-aged and …             LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974 ▶     Jaewoong Jang, Yoonju Jung, Youngeun Kim et al.     In this study, LPS-induced inflammatory responses in BEAS-2B human bronchial epithelial cells and human umbilical vein endothelial cell (HUVEC)s were found to be prevented by …             Pyrintegrin Induces Soft Tissue Formation by Transplanted or Endogenous Cells ▶     Bhranti S. Shah, Mo Chen, Takahiro Suzuki et al.     Focal adipose deficiency, such as lipoatrophy, lumpectomy or facial trauma, is a formidable challenge in reconstructive medicine, and yet scarcely investigated in experimental …             A de novo deletion mutation in SOX10 in a Chinese family with Waardenburg syndrome type 4 ▶     Xiong Wang, Yaowu Zhu, Na Shen et al.     Waardenburg syndrome type 4 (WS4) or Waardenburg-Shah syndrome is a rare genetic disorder with a prevalence of <1/1,000,000 and characterized by the association of congenital …             Combination of IL-6 and sIL-6R differentially regulate varying levels of RANKL-induced osteoclastogenesis through NF-κB, ERK and JNK signaling pathways ▶     Wei Feng, Hongrui Liu, Tingting Luo et al.     Interleukin (IL)-6 is known to indirectly enhance osteoclast formation by promoting receptor activator of nuclear factor kappa-B ligand (RANKL) production by osteoblastic/stromal …             Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro ▶     Wei Yi, Jingjing Shi, Guanguan Zhao et al.     Thiazolidinediones (TZD) function as potent anti-diabetic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ), but …             Mastoid vibration affects dynamic postural control during gait in healthy older adults ▶     Jung Hung Chien, Mukul Mukherjee, Jenny Kent et al.     Vestibular disorders are difficult to diagnose early due to the lack of a systematic assessment. Our previous work has developed a reliable experimental design and the result …             RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP ▶     Tsung-Yuan Tsai, Wei-Ting Wang, Hao-Kang Li et al.     Multifunctional RNA helicase DDX3 participates in HCV infection, one of the major causes of hepatic steatosis. Here, we investigated the role of DDX3 in hepatic lipid metabolism. …             Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication ▶     Kjersti M. Aagaard, Anismrita Lahon, Melissa A. Suter et al.     Zika virus (ZIKV) is an emerging mosquito-borne (Aedes genus) arbovirus of the Flaviviridae family. Although ZIKV has been predominately associated with a mild or asymptomatic …             Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway ▶     Jialin Duan, Yue Guan, Fei Mu et al.     Hyperglycemia-induced reactive oxygen species (ROS) generation contributes to development of diabetic cardiomyopathy (DCM). This study was designed to determine the effect of an …             Low level of swiprosin-1/EFhd2 in vestibular nuclei of spontaneously hypersensitive motion sickness mice ▶     Zhi-Bin Wang, Ping Han, Ling-Chang Tong et al.     Susceptibility to motion sickness (MS) varies considerably among humans. However, the cause of such variation is unclear. Here, we used a classical genetic approach to obtain …             Behavioural Effects of Using Sulfasalazine to Inhibit Glutamate Released by Cancer Cells: A Novel target for Cancer-Induced Depression ▶     Mina G. Nashed, Robert G. Ungard, Kimberly Young et al.     Despite the lack of robust evidence of effectiveness, current treatment options for cancer-induced depression (CID) are limited to those developed for non-cancer related …             Genotype-phenotype relationship in patients with arrhythmogenic right ventricular cardiomyopathy caused by desmosomal gene mutations: A systematic review and meta-analysis ▶     Zhenyan Xu, Wengen Zhu, Cen Wang et al.     The relationship between clinical phenotypes and desmosomal gene mutations in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) is poorly characterized. …             Genome-wide association study identifies four SNPs associated with response to platinum-based neoadjuvant chemotherapy for cervical cancer ▶     Xiong Li, Kecheng Huang, Qinghua Zhang et al.     To identify genomic markers associated with the response to neoadjuvant chemotherapy (NACT) in patients with cervical cancer, we performed a three-stage genome-wide association …             Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor ▶     César S. Huertas, Santos Domínguez-Zotes, Laura M. Lechuga     Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects …             The role of miR-26a and miR-30b in HER2+ breast cancer trastuzumab resistance and regulation of the CCNE2 gene ▶     Eduardo Tormo, Anna Adam-Artigues, Sandra Ballester et al.     A subset of HER2+ breast cancer patients manifest clinical resistance to trastuzumab. Recently, miR-26a and miR-30b have been identified as trastuzumab response regulators, and …             Associations of maternal pre-pregnancy body mass index and gestational weight gain with birth outcomes in Shanghai, China ▶     Lingli Xiao, Guodong Ding, Angela Vinturache et al.     Recent data suggests that abnormal maternal pre-pregnancy body mass index (BMI) or gestational weight gain (GWG) is associated with unfavorable delivery outcomes. However, …             Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans ▶     Chui Ming Gemmy Cheung, Augustinus Laude, Ian Yeo et al.     To examine the association of systemic, ocular and genetic risk factors in neovascular age-related macular degeneration (nAMD) in a large cohort of Asian patients, and to further …             Relationship between bony tunnel and knee function in patients after patellar dislocation triple surgeries—a CT-based study ▶     Le Qin, Mei Li, Weiwu Yao et al.     We aimed to assess the CT-based bony tunnel valuations and their correlation with knee function after patellar dislocation triple surgeries. A retrospective study was performed …             Physical Activity, TV Watching Time, Sleeping, and Risk of Obesity and Hyperglycemia in the Offspring of Mothers with Gestational Diabetes Mellitus ▶     Tao Zhang, Peng Wang, Huikun Liu et al.     We investigated the association of physical activity, TV watching time, sleeping time with the risks of obesity and hyperglycemia among 1263 offspring aged 1–5 years of mothers …             Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling ▶     Liming Yu, Bing Gong, Weixun Duan et al.     Enhancing mitochondrial biogenesis and reducing mitochondrial oxidative stress have emerged as crucial therapeutic strategies to ameliorate diabetic myocardial …             Genomic structural variations for cardiovascular and metabolic comorbidity ▶     Maria S. Nazarenko, Aleksei A. Sleptcov, Igor N. Lebedev et al.     The objective of this study was to identify genes targeted by both copy number and copy-neutral changes in the right coronary arteries in the area of advanced atherosclerotic …             Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations ▶     Shuquan Rao, Yao Yao, Joanne Ryan et al.     Rs1344706 in the the zinc finger protein 804A (ZNF804A) gene has been identified to be associated with schizophrenia and bipolar disorder (BD) in Europeans. However, whether …             Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na+/K+ ATPase Activity in Dendritic Cells ▶     Zohreh Hosseinzadeh, Yogesh Singh, Derya R. Shimshek et al.     Leucine-rich repeat kinase 2 (Lrrk2) has been implicated in the pathophysiology of Parkinson’s disease. Lrrk2 is expressed in diverse cells including neurons and dendritic cells …             Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity ▶     Yukti Choudhury, Yi Chin Toh, Jiangwa Xing et al.     Idiosyncratic drug-induced hepatotoxicity is a major cause of liver damage and drug pipeline failure, and is difficult to study as patient-specific features are not readily …             The Role of Vascular Endothelial Growth Factor in Small-airway Remodelling in a Rat Model of Chronic Obstructive Pulmonary Disease ▶     Lu Wang, Zhibo Xu, Bin Chen et al.     Small-airway remodelling is one of the most remarkable pathological features of chronic obstructive pulmonary disease (COPD), in which angiogenesis plays a critical role that …             Safety and Efficacy of Single-Stage Surgical Treatment for Congenital Scoliosis Associated with Intraspinal Mass ▶     Bo-bo Zhang, Hui-ren Tao, Tai-lin Wu et al.     For congenital scoliosis associated with intraspinal anomaly, surgical treatment is often advocated. However, the safety and efficacy of single-stage intraspinal mass resection …             Randomized controlled trial of the effect of phytosterols-enriched low-fat milk on lipid profile in Chinese ▶     Ching-Lung Cheung, Daniel Ka-Chun Ho, Chor-Wing Sing et al.     Phytosterols found naturally in plants are known to reduce cholesterol absorption in the gut. The traditional southern Chinese diet typically contains many vegetables and not …             Albuminuria is an independent risk factor of T4 elevation in chronic kidney disease ▶     Xin Du, Binbin Pan, Wenwen Li et al.     This study was to explore the association between thyroid dysfunction and albuminuria. 581 cases with chronic kidney disease (CKD) were included in this study. The clinical …             Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib ▶     Arancha Cebrián, Teresa Gómez del Pulgar, María José Méndez-Vidal et al.     Sunitinib is the currently standard treatment for metastatic renal cell carcinoma (mRCC). Multiple candidate predictive biomarkers for sunitinib response have been evaluated but …             ApoA-IV improves insulin sensitivity and glucose uptake in mouse adipocytes via PI3K-Akt Signaling ▶     Xiaoming Li, Fei Wang, Min Xu et al.     Insulin resistance is a risk factor for type 2 diabetes mellitus. We investigated the effect of ApoA-IV on glucose uptake in the adipose and muscle tissues of mice and cultured …             SWATH-based proteomics identified carbonic anhydrase 2 as a potential diagnosis biomarker for nasopharyngeal carcinoma ▶     Yanzhang Luo, Tin Seak Mok, Xiuxian Lin et al.     Nasopharyngeal carcinoma (NPC) is a serious threat to public health, and the biomarker discovery is of urgent needs. The data-independent mode (DIA) based sequential window …             Corrigendum: Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay ▶     Wim Trypsteen, Pejman Mohammadi, Clarissa Van Hecke et al.                 Utility of baseline, interim and end-of-treatment 18F-FDG PET/CT in extranodal natural killer/T-cell lymphoma patients treated with L-asparaginase/pegaspargase ▶     Yu Chang, Xiaorui Fu, Zhenchang Sun et al.     Positron emission tomography-computed tomography (PET/CT) is widely used for initial staging and monitoring treatment responses in Hodgkin and diffuse large B-cell lymphoma. …             Males develop faster and more severe hepatocellular carcinoma than females in krasV12 transgenic zebrafish ▶     Yan Li, Hankun Li, Jan M. Spitsbergen et al.     Hepatocellular carcinoma (HCC) is more prevalent in men than women, but the reason for this gender disparity is not well understood. To investigate whether zebrafish could be …             Highly Sensitive Marker Panel for Guidance in Lung Cancer Rapid Diagnostic Units ▶     Sonia Blanco-Prieto, Loretta De Chiara, Mar Rodríguez-Girondo et al.     While evidence for lung cancer screening implementation in Europe is awaited, Rapid Diagnostic Units have been established in many hospitals to accelerate the early diagnosis of …             Whole-exome sequencing of 228 patients with sporadic Parkinson’s disease ▶     Cynthia Sandor, Frantisek Honti, Wilfried Haerty et al.     Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, affecting 1% of the population over 65 years characterized clinically by both motor and non-motor …             IL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide ▶     Wei Zhong, Ling Zhao, Tao Liu et al.     T cells are key players in immune-mediated rheumatoid arthritis (RA). We previously reported that interleukin (IL)-22+CD4+T helper (IL-22+ Th) cells and IL-22 critically control …             Biological Membrane-Packed Mesenchymal Stem Cells Treat Acute Kidney Disease by Ameliorating Mitochondrial-Related Apoptosis ▶     Xiaodong Geng, Quan Hong, Weiwei Wang et al.     The mortality of rhabdomyolysis-induced AKI remains high because no effective therapy exists. We investigated a new therapeutic method using MSCs. The aim of this study was to …             Selection of reference genes is critical for miRNA expression analysis in human cardiac tissue. A focus on atrial fibrillation ▶     Michela Masè, Margherita Grasso, Laura Avogaro et al.     MicroRNAs (miRNAs) are emerging as key regulators of complex biological processes in several cardiovascular diseases, including atrial fibrillation (AF). Reverse …             Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium ▶     Hanlu Fan, Xiaohong Du, Jingyuan Zhang et al.     The Ebola crisis occurred in West-Africa highlights the urgency for its clinical treatments. Currently, no Food and Drug Administration (FDA)-approved therapeutics are available. …             Treatment effects of lysozyme-shelled microbubbles and ultrasound in inflammatory skin disease ▶     Ai-Ho Liao, Chi-Ray Hung, Chieh-Fu Lin et al.     Acne vulgaris is the most common skin disorder, and is caused by Propionibacterium acnes (P. acnes) and can induce inflammation. Antibiotic therapy often needs to be administered …             A 10-year observation of PM2.5-bound nickel in Xi’an, China: Effects of source control on its trend and associated health risks ▶     Hongmei Xu, Steven Sai Hang Ho, Junji Cao et al.     This study presents the first long term (10-year period, 2004–2013) datasets of PM2.5-bound nickel (Ni) concentration obtained from the daily sample in urban of Xi’an, …             A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk ▶     Rachel J. J. Elands, Colinda C. J. M. Simons, Mona Riemenschneider et al.     Data from GWAS suggest that SNPs associated with complex diseases or traits tend to co-segregate in regions of low recombination, harbouring functionally linked gene clusters. …             Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis ▶     Sabrina Cipriani, Adriana Carino, Dario Masullo et al.     The small heterodimer partner (SHP) is an orphan nuclear receptor that lacks the DNA binding domain while conserves a putative ligand-binding site, thought that endogenous …             Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis ▶     Tobias V. Lanz, Sarah K. Williams, Aleksandar Stojic et al.     The catabolism of tryptophan to immunosuppressive and neuroactive kynurenines is a key metabolic pathway regulating immune responses and neurotoxicity. The rate-limiting step is …             Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells ▶     Nami Kim, Miso Nam, Mi Sun Kang et al.     This study characterizes the human metabolic response to piperine, a curcumin extract, and the details of its underlying molecular mechanism. Using 1H-NMR-based metabolome …             A new serotonin 5-HT6 receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding ▶     Juan A. González-Vera, Rocío A. Medina, Mar Martín-Fontecha et al.     Serotonin 5-HT6 receptor has been proposed as a promising therapeutic target for cognition enhancement though the development of new antagonists is still needed to validate these …             Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes ▶     Carmelo Milioto, Adriana Malena, Eleonora Maino et al.     Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease characterized by the loss of lower motor neurons. 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