Cell Death & Disease Contents: 30 Apr 2022

The latest content from Cell Death & Disease: 30 April 2022

CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer Ruiting Guo, Xixi Cui [...] Wenjuan Li Article | 28 April 2022 | Article number: 409 |  doi: 10.1038/s41419-022-04811-y

Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors Ashlyn Parkhurst, Sabrina Z. Wang [...] Jeffrey A. Rubens Article | 28 April 2022 | Article number: 410 |  doi: 10.1038/s41419-022-04868-9

MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization Jie Zhang, Yu Liu [...] Jinhua Zhang Article | 28 April 2022 | Article number: 411 |  doi: 10.1038/s41419-022-04802-z

Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progression Yingying Tong, Zheng Zhang [...] Dong Yan Article | 28 April 2022 | Article number: 413 |  doi: 10.1038/s41419-022-04779-9

Defective hematopoietic differentiation of immune aplastic anemia patient-derived iPSCs Maria Florencia Tellechea, Flávia S. Donaires [...] Rodrigo T. Calado Article | 28 April 2022 | Article number: 412 |  doi: 10.1038/s41419-022-04850-5

Chromatin complexes subunit BAP18 promotes triple-negative breast cancer progression through transcriptional activation of oncogene S100A9 Yin-Ling Zhang, Ling Deng [...] Da-Qiang Li Article | 28 April 2022 | Article number: 408 |  doi: 10.1038/s41419-022-04785-x

YAP-dependent Wnt5a induction in hypertrophic adipocytes restrains adiposity Gwan-Jun Lee, Youn Ju Kim [...] Hyunsung Park Article | 27 April 2022 | Article number: 407 |  doi: 10.1038/s41419-022-04847-0

Antiapoptotic Protein FAIM2 is targeted by miR-3202, and DUX4 via TRIM21, leading to cell death and defective myogenesis Hossam A. N. Soliman, Erik A. Toso [...] Michael Kyba Article | 25 April 2022 | Article number: 405 |  doi: 10.1038/s41419-022-04804-x

PRKDC promotes hepatitis B virus transcription through enhancing the binding of RNA Pol II to cccDNA Yao Fan, Yi Liang [...] Hui Fan Article | 25 April 2022 | Article number: 404 |  doi: 10.1038/s41419-022-04852-3

Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes leading to cognitive impairment Manman Zhang, Wenliang Gong [...] Baoman Li Article | 25 April 2022 | Article number: 406 |  doi: 10.1038/s41419-022-04858-x

SHANK1 facilitates non-small cell lung cancer processes through modulating the ubiquitination of Klotho by interacting with MDM2 Bo Chen, Hongye Zhao [...] Jianqing Wu Article | 25 April 2022 | Article number: 403 |  doi: 10.1038/s41419-022-04860-3

Targeting DRD2 by the antipsychotic drug, penfluridol, retards growth of renal cell carcinoma via inducing stemness inhibition and autophagy-mediated apoptosis Min-Che Tung, Yung-Wei Lin [...] Ming-Hsien Chien Article | 23 April 2022 | Article number: 400 |  doi: 10.1038/s41419-022-04828-3

Proximal tubular RAGE mediated the renal fibrosis in UUO model mice via upregulation of autophagy Bohao Liu, Tianshi Sun [...] Dongshan Zhang Article | 23 April 2022 | Article number: 399 |  doi: 10.1038/s41419-022-04856-z

Autophagy guards tendon homeostasis Costanza Montagna, Rene B. Svensson [...] Michael Kjær Article | 23 April 2022 | Article number: 402 |  doi: 10.1038/s41419-022-04824-7

A novel oncogenic seRNA promotes nasopharyngeal carcinoma metastasis Yuan Tan, Chonghua Jiang [...] Faqing Tang Article | 23 April 2022 | Article number: 401 |  doi: 10.1038/s41419-022-04846-1

p63, a key regulator of Ago2, links to the microRNA-144 cluster Benfan Wang, H. Helena Wu [...] Roger Leng Article | 22 April 2022 | Article number: 397 |  doi: 10.1038/s41419-022-04854-1

HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer Misha Mao, Yunlu Jia [...] Linbo Wang Article | 22 April 2022 | Article number: 396 |  doi: 10.1038/s41419-022-04833-6

Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy Caterina Vianello, Veronica Cocetta [...] Monica Montopoli Article | 22 April 2022 | Article number: 398 |  doi: 10.1038/s41419-022-04741-9

A stop-gain mutation in GXYLT1 promotes metastasis of colorectal cancer via the MAPK pathway Lin Peng, Min Zhao [...] Xiangqian Su Article | 22 April 2022 | Article number: 395 |  doi: 10.1038/s41419-022-04844-3

Mechanism of cancer stemness maintenance in human liver cancer Ning Liang, Tao Yang [...] Xianli He Review Article | 21 April 2022 | Article number: 394 |  doi: 10.1038/s41419-022-04848-z

Regorafenib inhibits epithelial-mesenchymal transition and suppresses cholangiocarcinoma metastasis via YAP1-AREG axis Yu-Chan Chang, Chien-Hsiu Li [...] Michael Hsiao Article | 21 April 2022 | Article number: 391 |  doi: 10.1038/s41419-022-04816-7

VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway Erica de Sousa, Marília Inês Móvio [...] Alexandre Hiroaki Kihara Article | 21 April 2022 | Article number: 393 |  doi: 10.1038/s41419-022-04755-3

Integrated DNA and RNA sequencing reveals early drivers involved in metastasis of gastric cancer Jieyun Zhang, Fatao Liu [...] Weijian Guo Article | 21 April 2022 | Article number: 392 |  doi: 10.1038/s41419-022-04838-1

Long noncoding RNA ZFP36L2-AS functions as a metabolic modulator to regulate muscle development Bolin Cai, Manting Ma [...] Qinghua Nie Article | 21 April 2022 | Article number: 389 |  doi: 10.1038/s41419-022-04772-2

Hsa-miR-30a-3p overcomes the acquired protective autophagy of bladder cancer in chemotherapy and suppresses tumor growth and muscle invasion Thomas I-Sheng Hwang, Po-Chun Chen [...] An-Chen Chang Article | 21 April 2022 | Article number: 390 |  doi: 10.1038/s41419-022-04791-z

HGF/c-Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR/NGF axis Tao Qin, Ying Xiao [...] Zheng Wang Article | 21 April 2022 | Article number: 387 |  doi: 10.1038/s41419-022-04799-5

Activation of FXR and inhibition of EZH2 synergistically inhibit colorectal cancer through cooperatively accelerating FXR nuclear location and upregulating CDX2 expression Junhui Yu, Kui Yang [...] Wei Zhao Article | 21 April 2022 | Article number: 388 |  doi: 10.1038/s41419-022-04745-5

Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer Lin Zhao, Yuanyuan Liu [...] Jia Wang Review Article | 20 April 2022 | Article number: 378 |  doi: 10.1038/s41419-022-04821-w

Mitochondrial oxidative phosphorylation is dispensable for survival of CD34+ chronic myeloid leukemia stem and progenitor cells Jin-Song Yan, Meng-Ying Yang [...] Ying Lu Article | 20 April 2022 | Article number: 384 |  doi: 10.1038/s41419-022-04842-5

Restoration of ER proteostasis attenuates remote apoptotic cell death after spinal cord injury by reducing autophagosome overload Elisa Bisicchia, Roberta Mastrantonio [...] Maria Teresa Viscomi Article | 20 April 2022 | Article number: 381 |  doi: 10.1038/s41419-022-04830-9

Tumor-associated macrophage-derived exosomes transmitting miR-193a-5p promote the progression of renal cell carcinoma via TIMP2-dependent vasculogenic mimicry Qing Liu, Enyang Zhao [...] Bosen You Article | 20 April 2022 | Article number: 382 |  doi: 10.1038/s41419-022-04814-9

The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions Madeleine Eichler, Ute Distler [...] Gergely Imre Article | 20 April 2022 | Article number: 386 |  doi: 10.1038/s41419-022-04829-2

Implication of autophagy in the antifibrogenic effect of Rilpivirine: when more is less Federico Lucantoni, Ana M. Benedicto [...] Nadezda Apostolova Article | 20 April 2022 | Article number: 385 |  doi: 10.1038/s41419-022-04789-7

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa Alonso Sánchez-Cruz, Alberto Hernández-Pinto [...] Enrique J. de la Rosa Article | 20 April 2022 | Article number: 383 |  doi: 10.1038/s41419-022-04839-0

Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis Jingyi Zhang, Yuetong Wang [...] Yongkui Jing Article | 20 April 2022 | Article number: 379 |  doi: 10.1038/s41419-022-04810-z

Exosomal miR-146a-5p and miR-155-5p promote CXCL12/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts Dong Wang, Xiaohui Wang [...] Xinfeng Yu Article | 20 April 2022 | Article number: 380 |  doi: 10.1038/s41419-022-04825-6

The miR-532-E2F1 feedback loop contributes to gastric cancer progression Shanting Gao, Xiaomin Bu [...] Liuqing Yang Article | 19 April 2022 | Article number: 376 |  doi: 10.1038/s41419-022-04832-7

Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer Yongqi Zhen, Zhaoxin Yuan [...] Xian-Li Zhou Article | 19 April 2022 | Article number: 375 |  doi: 10.1038/s41419-022-04823-8

ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer Eunju Kim, Yoon-Jin Kim [...] Zheng Chen Article | 19 April 2022 | Article number: 374 |  doi: 10.1038/s41419-022-04826-5

NOX activation in reactive astrocytes regulates astrocytic LCN2 expression and neurodegeneration Ruijia Liu, Jun Wang [...] Gulnaz Begum Article | 19 April 2022 | Article number: 371 |  doi: 10.1038/s41419-022-04831-8

xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade Bufu Tang, Jinyu Zhu [...] Jiansong Ji Article | 19 April 2022 | Article number: 373 |  doi: 10.1038/s41419-022-04827-4

Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages Ji Cao, Longlong Li [...] Haitian Ma Article | 19 April 2022 | Article number: 372 |  doi: 10.1038/s41419-022-04841-6

UHRF1 establishes crosstalk between somatic and germ cells in male reproduction Yanqing Wu, Peng Duan [...] Shuiqiao Yuan Article | 19 April 2022 | Article number: 377 |  doi: 10.1038/s41419-022-04837-2

Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis Xuetian Yue, Jianming Wang [...] Wenwei Hu Article | 19 April 2022 | Article number: 370 |  doi: 10.1038/s41419-022-04820-x

Cooperative effects of RIG-I-like receptor signaling and IRF1 on DNA damage-induced cell death David Y. Zander, Sandy S. Burkart [...] Marco Binder Article | 18 April 2022 | Article number: 364 |  doi: 10.1038/s41419-022-04797-7

MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma Ji Wang, Yanming Chen [...] Qing Lan Article | 18 April 2022 | Article number: 360 |  doi: 10.1038/s41419-022-04845-2

B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36 Hao Zhang, Yue Li [...] Jiahong Xia Article | 18 April 2022 | Article number: 359 |  doi: 10.1038/s41419-022-04812-x

METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition Yue Zhu, Xinzhi Peng [...] Miaoyun Long Article | 18 April 2022 | Article number: 358 |  doi: 10.1038/s41419-022-04817-6

Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation Mingying Hou, Zhengbo Shao [...] Huiping Yuan Article | 18 April 2022 | Article number: 362 |  doi: 10.1038/s41419-022-04836-3

Bloom syndrome helicase contributes to germ line development and longevity in zebrafish Tamás Annus, Dalma Müller [...] Máté Varga Article | 18 April 2022 | Article number: 363 |  doi: 10.1038/s41419-022-04815-8

An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor Gerasimos Anagnostopoulos, Omar Motiño [...] Guido Kroemer Article | 18 April 2022 | Article number: 356 |  doi: 10.1038/s41419-022-04834-5

Mesenchymal stem cells empower T cells in the lymph nodes via MCP-1/PD-L1 axis Yifan He, Yan Qu [...] Songtao Shi Article | 18 April 2022 | Article number: 365 |  doi: 10.1038/s41419-022-04822-9

Cancer cells adapt FAM134B/BiP mediated ER-phagy to survive hypoxic stress Sandhya Chipurupalli, Raja Ganesan [...] Nirmal Robinson Article | 18 April 2022 | Article number: 357 |  doi: 10.1038/s41419-022-04813-w

circFAM120B functions as a tumor suppressor in esophageal squamous cell carcinoma via the miR-661/PPM1L axis and the PKR/p38 MAPK/EMT pathway Huan Song, Dan Tian [...] Jianming Wang Article | 18 April 2022 | Article number: 361 |  doi: 10.1038/s41419-022-04818-5

Interaction between macrophages and ferroptosis Yan Yang, Yu Wang [...] Miao Yan Review Article | 16 April 2022 | Article number: 355 |  doi: 10.1038/s41419-022-04775-z

The nuclear receptor REV-ERBα is implicated in the alteration of β-cell autophagy and survival under diabetogenic conditions Matthew R. Brown, Damien Laouteouet [...] Safia Costes Article | 15 April 2022 | Article number: 353 |  doi: 10.1038/s41419-022-04767-z

KDM5B promotes tumorigenesis of Ewing sarcoma via FBXW7/CCNE1 axis Binbin Chen, Huimou Chen [...] Yizhuo Zhang Article | 15 April 2022 | Article number: 354 |  doi: 10.1038/s41419-022-04800-1

Targeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism Trace M. Jones, Claudia M. Espitia [...] Steffan T. Nawrocki Article | 15 April 2022 | Article number: 350 |  doi: 10.1038/s41419-022-04798-6

EGFR/MET promotes hepatocellular carcinoma metastasis by stabilizing tumor cells and resisting to RTKs inhibitors in circulating tumor microemboli Shouyang Song, Zhen Yu [...] Chengyong Qin Article | 15 April 2022 | Article number: 351 |  doi: 10.1038/s41419-022-04796-8

RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression Tingting Zhou, Shengli Wang [...] Yue Zhao Article | 15 April 2022 | Article number: 352 |  doi: 10.1038/s41419-022-04787-9

Reticulon 2 promotes gastric cancer metastasis via activating endoplasmic reticulum Ca2+ efflux-mediated ERK signalling Shushu Song, Bo Liu [...] Hongshan Wang Article | 15 April 2022 | Article number: 349 |  doi: 10.1038/s41419-022-04757-1

Lamin A and the LINC complex act as potential tumor suppressors in Ewing Sarcoma Francesca Chiarini, Francesca Paganelli [...] Katia Scotlandi Article | 14 April 2022 | Article number: 346 |  doi: 10.1038/s41419-022-04729-5

MLKL deficiency in BrafV600EPten−/− melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice Sofie Martens, Nozomi Takahashi [...] Peter Vandenabeele Article | 14 April 2022 | Article number: 347 |  doi: 10.1038/s41419-022-04819-4

USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction Mi-Jeong Kim, Yoon Min [...] Ki-Young Lee Article | 14 April 2022 | Article number: 348 |  doi: 10.1038/s41419-022-04808-7

Generation of resolving memory neutrophils through pharmacological training with 4-PBA or genetic deletion of TRAM RuiCi Lin, Ziyue Yi [...] Liwu Li Article | 13 April 2022 | Article number: 345 |  doi: 10.1038/s41419-022-04809-6

Downregulation of REST in the cochlea contributes to age-related hearing loss via the p53 apoptosis pathway Hongchen Li, Mingshun Lu [...] Ping Lv Article | 13 April 2022 | Article number: 343 |  doi: 10.1038/s41419-022-04774-0

TGF-β induces GBM mesenchymal transition through upregulation of CLDN4 and nuclear translocation to activate TNF-α/NF-κB signal pathway Tengfeng Yan, Yinqiu Tan [...] Qianxue Chen Article | 13 April 2022 | Article number: 339 |  doi: 10.1038/s41419-022-04788-8

Global characterization of extrachromosomal circular DNAs in advanced high grade serous ovarian cancer Yixuan Cen, Yifeng Fang [...] Junfen Xu Article | 13 April 2022 | Article number: 342 |  doi: 10.1038/s41419-022-04807-8

Serum-derived extracellular vesicles facilitate temozolomide resistance in glioblastoma through a HOTAIR-dependent mechanism Xiaosong Wang, Xiaojun Yu [...] Junfei Han Article | 13 April 2022 | Article number: 344 |  doi: 10.1038/s41419-022-04699-8

IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis Chengcheng Song, Shuqiang Wang [...] Quan Hong Article | 13 April 2022 | Article number: 340 |  doi: 10.1038/s41419-022-04803-y

Osteopontin promotes hepatocellular carcinoma progression through inducing JAK2/STAT3/NOX1-mediated ROS production Qipeng Wu, Le Li [...] Luyong Zhang Article | 13 April 2022 | Article number: 341 |  doi: 10.1038/s41419-022-04806-9

Identification of a novel mechanism for reversal of doxorubicin-induced chemotherapy resistance by TXNIP in triple-negative breast cancer via promoting reactive oxygen-mediated DNA damage Yiting Chen, Xueping Feng [...] Bin Zhang Article | 12 April 2022 | Article number: 338 |  doi: 10.1038/s41419-022-04783-z

Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy Hui Kong, Hongran Zhao [...] Yan Cui Article | 12 April 2022 | Article number: 336 |  doi: 10.1038/s41419-022-04786-w

Evolution of gene expression signature in mammary gland stem cells from neonatal to old mice Xiaoling Huang, Yue Xu [...] Zuoren Yu Article | 12 April 2022 | Article number: 335 |  doi: 10.1038/s41419-022-04777-x

Acute lymphoblastic leukemia-derived extracellular vesicles affect quiescence of hematopoietic stem and progenitor cells Aleksandra Georgievski, Anaïs Michel [...] Ronan Quéré Article | 12 April 2022 | Article number: 337 |  doi: 10.1038/s41419-022-04761-5

Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype Seungyeon Ryu, Myeongwoo Jung [...] Eun Kyung Lee Article | 11 April 2022 | Article number: 329 |  doi: 10.1038/s41419-022-04792-y

Neurotropic EV71 causes encephalitis by engaging intracellular TLR9 to elicit neurotoxic IL12-p40-iNOS signaling Rai-Hua Lai, Yen-Hung Chow [...] Jyh-Lyh Juang Article | 11 April 2022 | Article number: 328 |  doi: 10.1038/s41419-022-04771-3

BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy Kun Liu, Qian Zhao [...] Tongbiao Zhao Article | 11 April 2022 | Article number: 334 |  doi: 10.1038/s41419-022-04795-9

MFSD4A inhibits the malignant progression of nasopharyngeal carcinoma by targeting EPHA2 Huiyun Yang, Guanjie Qin [...] Wei Jiang Article | 11 April 2022 | Article number: 332 |  doi: 10.1038/s41419-022-04793-x

SLC25A38 as a novel biomarker for metastasis and clinical outcome in uveal melanoma Zhongyi Fan, Jingjing Duan [...] Xiaojie Xu Article | 11 April 2022 | Article number: 330 |  doi: 10.1038/s41419-022-04718-8

Fatty acid-binding protein 4 is a therapeutic target for septic acute kidney injury by regulating inflammatory response and cell apoptosis Bo Wang, Jun Xu [...] Liang Ma Article | 11 April 2022 | Article number: 333 |  doi: 10.1038/s41419-022-04794-w

CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma Min Tang, Xin Dong [...] Ya Cao Article | 11 April 2022 | Article number: 331 |  doi: 10.1038/s41419-022-04730-y

ΔNp63α promotes Bortezomib resistance via the CYGB–ROS axis in head and neck squamous cell carcinoma Peng Zhou, Caiyun Zhang [...] Hongliang Zheng Article | 09 April 2022 | Article number: 327 |  doi: 10.1038/s41419-022-04790-0

Angiotensin II related glial cell activation and necroptosis of retinal ganglion cells after systemic hypotension in glaucoma Soo Ji Jeon, Jungbin Huh [...] Hae Young Lopilly Park Article | 09 April 2022 | Article number: 323 |  doi: 10.1038/s41419-022-04762-4

USP26 promotes anaplastic thyroid cancer progression by stabilizing TAZ Jianing Tang, Yongwen Luo & Liang Xiao Article | 09 April 2022 | Article number: 326 |  doi: 10.1038/s41419-022-04781-1

Suppression of histone deacetylase 1 by JSL-1 attenuates the progression and metastasis of cholangiocarcinoma via the TPX2/Snail axis Lu Xu, Weizhong Yang [...] Wuyuan Zhou Article | 09 April 2022 | Article number: 324 |  doi: 10.1038/s41419-022-04571-9

Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer's disease Xin-Kang Tong, Jessika Royea & Edith Hamel Article | 09 April 2022 | Article number: 325 |  doi: 10.1038/s41419-022-04784-y

HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis Youwen Tan, Yan Huang [...] Yongmin Yan Article | 08 April 2022 | Article number: 319 |  doi: 10.1038/s41419-022-04764-2

Hsa_circRNA_0088036 acts as a ceRNA to promote bladder cancer progression by sponging miR-140-3p Jun Yang, Manlong Qi [...] Kefeng Wang Article | 08 April 2022 | Article number: 322 |  doi: 10.1038/s41419-022-04732-w

Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia Oussama ElMokh, Saki Matsumoto [...] Michel A. Duchosal Article | 08 April 2022 | Article number: 320 |  doi: 10.1038/s41419-022-04763-3

Ischemia-induced cleavage of OPA1 at S1 site aggravates mitochondrial fragmentation and reperfusion injury in neurons Xiang Li, Haiying Li [...] Gang Chen Article | 08 April 2022 | Article number: 321 |  doi: 10.1038/s41419-022-04782-0

Some mice lacking intrinsic, as well as death receptor induced apoptosis and necroptosis, can survive to adulthood Francine F. S. Ke, Kerstin Brinkmann [...] Andreas Strasser Comment | 07 April 2022 | Article number: 317 |  doi: 10.1038/s41419-022-04731-x

A noncoding regulatory RNA Gm31932 induces cell cycle arrest and differentiation in melanoma via the miR-344d-3-5p/Prc1 (and Nuf2) axis Dan Wang, Jianfei Chen [...] Defang Li Article | 07 April 2022 | Article number: 314 |  doi: 10.1038/s41419-022-04736-6

TMEM189 negatively regulates the stability of ULK1 protein and cell autophagy Jiahong Yu, Liujing Qu [...] Yingyu Chen Article | 07 April 2022 | Article number: 316 |  doi: 10.1038/s41419-022-04722-y

Inhibition of the CEBPβ-NFκB interaction by nanocarrier-packaged Carnosic acid ameliorates glia-mediated neuroinflammation and improves cognitive function in an Alzheimer's disease model Wang Yi-Bin, Li Xiang [...] Wang Chun-Yan Article | 07 April 2022 | Article number: 318 |  doi: 10.1038/s41419-022-04765-1

SorCS3 promotes the internalization of p75NTR to inhibit GBM progression Yanqiu Zhang, Yue Li [...] Dongliang Li Article | 07 April 2022 | Article number: 313 |  doi: 10.1038/s41419-022-04753-5

Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse Aladin Haimovici, Christoph Höfer [...] Georg Häcker Article | 07 April 2022 | Article number: 315 |  doi: 10.1038/s41419-022-04768-y

Mitochondria bridge HIF signaling and ferroptosis blockage in acute kidney injury Wenju Li, Zhidan Xiang [...] Shaolin Shi Review Article | 06 April 2022 | Article number: 308 |  doi: 10.1038/s41419-022-04770-4

TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis Yunwei Lou, Xueqin Tian [...] Hui Wang Article | 06 April 2022 | Article number: 311 |  doi: 10.1038/s41419-022-04769-x

SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation Yuan Yuan, Danyang Zhou [...] Kai Zhang Article | 06 April 2022 | Article number: 312 |  doi: 10.1038/s41419-022-04717-9

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