Nature Chemical Biology Contents: Volume 18 Number 5

In this Issue: Editorial Research Highlights News & Views Perspectives Review Articles Articles Amendments & Corrections

Nature Chemical Biology Contents: Volume 18 Issue 5

Editorial

Retooling metabolism Editorial | 28 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01036-0

Research Highlights

The ties that bind Caitlin Deane Research Highlight | 28 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01029-z

Live from the liver Caitlin Deane Research Highlight | 28 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01030-6

Thrown for a loop Caitlin Deane Research Highlight | 28 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01031-5

A vicious cycle Yiyun Song Research Highlight | 28 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01032-4

News & Views

CRISP(e)R drug discovery Jason H. Yang News & Views | 23 February 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-00979-8

Enzyme assemblies on demand Alexander A. Green News & Views | 25 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01021-7

A new RNA performs old chemistry David A. Hiller & Scott A. Strobel News & Views | 17 March 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-00998-5

XaaP-ing DPP8/9 for CARD8 activation Jessie Kulsuptrakul & Patrick S. Mitchell News & Views | 14 February 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-021-00958-5

Perspectives

Targeting allosteric regulation of cancer metabolism Daniel M. Kremer & Costas A. Lyssiotis Perspective | 28 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-00997-6

Genetically encoded tools for measuring and manipulating metabolism Mangyu Choe & Denis V. Titov Perspective | 28 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01012-8

Review Articles

Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel Michael P. Murphy & Edward T. Chouchani Review Article | 28 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01004-8

Lipid metabolism in T cell signaling and function Seon Ah Lim, Wei Su, Nicole M. Chapman & Hongbo Chi Review Article | 28 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01017-3

Articles

Combining CRISPRi and metabolomics for functional annotation of compound libraries Miquel Anglada-Girotto, Gabriel Handschin, Karin Ortmayr, Adrian I. Campos, Ludovic Gillet et al. Article | 22 February 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-00970-3

Dynamic modulation of enzyme activity by synthetic CRISPR–Cas6 endonucleases Alexander A. Mitkas, Mauricio Valverde & Wilfred Chen Article | 25 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01005-7

Metabolism of a hybrid algal galactan by members of the human gut microbiome Craig S. Robb, Joanne K. Hobbs, Benjamin Pluvinage, Greta Reintjes, Leeann Klassen et al. Article | 14 March 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-00983-y

Symmetric and asymmetric receptor conformation continuum induced by a new insulin Xiaochun Xiong, Alan Blakely, Jin Hwan Kim, John G. Menting, Ingmar B. Schäfer et al. Article | 14 March 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-00981-0

Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast Ruibing Chen, Jiaoqi Gao, Wei Yu, Xianghui Chen, Xiaoxin Zhai et al. Article | 28 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01014-6

The biosynthetic origin of ribofuranose in bacterial polysaccharides Steven D. Kelly, Danielle M. Williams, Jeremy T. Nothof, Taeok Kim, Todd L. Lowary et al. Article | 07 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01006-6

Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead Katherine D. Bauman, Vikram V. Shende, Percival Yang-Ting Chen, Daniela B. B. Trivella, Tobias A. M. Gulder et al. Article | 21 March 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-00993-w

Structure and mechanism of the methyltransferase ribozyme MTR1 Carolin P. M. Scheitl, Mateusz Mieczkowski, Hermann Schindelin & Claudia Höbartner Article | 17 March 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-00976-x

Structure and mechanism of a methyltransferase ribozyme Jie Deng, Timothy J. Wilson, Jia Wang, Xuemei Peng, Mengxiao Li et al. Article | 17 March 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-00982-z

M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome Sahana D. Rao, Qifeng Chen, Qinghui Wang, Elizabeth L. Orth-He, Michelle Saoi et al. Article | 14 February 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-021-00964-7

Amendments & Corrections

Author Correction: Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate Ryan J. Weiss, Philipp N. Spahn, Austin W. T. Chiang, Qing Liu, Jing Li et al. Author Correction | 30 March 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01022-6

Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries Miquel Anglada-Girotto, Gabriel Handschin, Karin Ortmayr, Adrian I. Campos, Ludovic Gillet et al. Author Correction | 08 April 2022 Nature Chemical Biology 18 | doi:10.1038/s41589-022-01028-0

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