IL-18: A Pleiotropic Pro-Inflammatory Cytokine

A Link between Innate and Adaptive Immunity Created for ignoble.experiment@arconati.us |  Web Version This is a paid advertisement.   Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine. It belongs to the IL-1 superfamily and participates in innate and acquired immunity. Recent studies have implicated the IL-18 pathway in autoimmune diseases, metabolic disorders, and cancers. IL-18 mediates host immunity by regulating IFN-γ production in synergy with IL-12. In the presence of IL-2, IL-18 stimulates natural killer (NK) cells, NKT cells, and established Th1 cells to produce IL-3, IL-9, and IL-13. IL-18 similarly activates downstream signal transduction as IL-1β. IL18 binds with its receptor IL-18 receptor α (IL-18Rα). IL-18Rβ / IL-18RAcP is subsequently recruited to the complex, and the downstream cellular signal is initiated. IL-18 signaling is negatively regulated by the secreted antagonist receptor IL-18BP. IL-18Rα may also bind IL-37 in association with SIGIRR to transduce an anti-inflammatory signal. Sino Biological has developed a panel of recombinant IL-18 and IL-18 receptor protein reagents to support the study of the biology of IL-18.   Recombinant IL-18 Cytokines and Receptors Sino Biological has produced high-quality recombinant IL-18 and receptor proteins from various species, such as human, mouse, cynomolgus, rhesus, rat, and canine. • Featured IL-18 Protein Human IL-18 Protein: 10119-HNCE   High-purity   Low-endotoxin   Tag-free   HPLC-verified > 95 % as determined by SEC-HPLC   Ability to induce IFN-gamma secretion by KG‑1 human acute myelogenous leukemia cells in the presence of TNF-alpha Batch-to-batch Consistency • Featured IL-18 Receptor Proteins Mouse IL-18Rα Protein (Cat#: 50094-M38H) Human IL-18BP Protein (Cat#: 10357-H08H) Binding Ability in a Functional ELISA, Bind to Mouse IL-18 (Cat: 50073-MNCE) Ability to Inhibit the IL-18-induced Response of KG-1 Human Acute Myelogenous Leukemia Cells • More Related Proteins Cytokine IL-18 Receptor IL-18Rα Receptor Accessory Protein IL-18Rβ / IL-18RAcP Receptor Antagonist & Decoy Receptor IL-18BP   Antibodies for IL-18 Cytokines and Receptors Sino Biological has developed a panel of antibodies targeting IL-18 cytokines and receptors that can be used in ELISA, WB, IF, IP, FCM, and ICC. Anti-IL-18Rβ / IL-18RAcP Antibody (Cat#: 10176-T24) Anti-IL-18 Antibody (Cat#: 310203-T44) Immunochemical Staining of Human IL-18Rβ in Human Colon Carcinoma Cells Immunochemical Staining of Human IL-18 in Human Lymph Node Cells • More Related Antibodies Anti-IL-18   Anti-IL-18Rα   Anti-IL-18Rβ   Anti-IL-18BP U.S.A Sino Biological US Inc. order_us@sinobiologicalus.com Europe Sino Biological Europe GmbH order_eu@sinobiologicaleu.com Global Sino Biological, Inc. order@sinobiological.com About this email: Future will occasionally send emails from our business partners promoting products and services likely to be of interest to our readers. Unsubscribe  |    Privacy Policy Future US LLC © 1100 13th St. NW, Suite 1000, Washington, DC 20005