Cell Death & Disease Contents: 31 Oct 2022

The latest content from Cell Death & Disease: 31 October 2022

Glioblastoma cell motility depends on enhanced oxidative stress coupled with mobilization of a sulfurtransferase Mirca S. Saurty-Seerunghen, Thomas Daubon [...] Marie-Pierre Junier Article | 30 October 2022 | Article number: 913 |  doi: 10.1038/s41419-022-05358-8

Desmoglein-2 is important for islet function and β-cell survival Kay K. Myo Min, Darling Rojas-Canales [...] Claudine S. Bonder Article | 29 October 2022 | Article number: 911 |  doi: 10.1038/s41419-022-05326-2

EGFL7 drives the evolution of resistance to EGFR inhibitors in lung cancer by activating NOTCH signaling Yubo Wang, Pu Chen [...] Mingwei Chen Article | 29 October 2022 | Article number: 910 |  doi: 10.1038/s41419-022-05354-y

Bromodomain-containing protein 4 (BRD4) as an epigenetic regulator of fatty acid metabolism genes and ferroptosis Minghua Yang, Ke Liu [...] Jun Huang Article | 29 October 2022 | Article number: 912 |  doi: 10.1038/s41419-022-05344-0

Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage Luiza Steffens Reinhardt, Xiajie Zhang [...] Kelly A. Avery-Kiejda Article | 28 October 2022 | Article number: 907 |  doi: 10.1038/s41419-022-05349-9

Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer Ricardo Coelho, Alessandra Tozzi [...] Viola Heinzelmann-Schwarz Article | 28 October 2022 | Article number: 909 |  doi: 10.1038/s41419-022-05347-x

Epigallocatechin-3-gallate inhibits osteoclastic differentiation by modulating mitophagy and mitochondrial functions Jaganmay Sarkar, Manjusri Das [...] Hiranmoy Das Article | 28 October 2022 | Article number: 908 |  doi: 10.1038/s41419-022-05343-1

Liquid biopsy in gastric cancer: predictive and prognostic biomarkers Zihao Zhang, Hao Wu [...] Leping Li Review Article | 27 October 2022 | Article number: 903 |  doi: 10.1038/s41419-022-05350-2

Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation Baochi Ou, Yuan Liu [...] Jingjie Zhang Article | 27 October 2022 | Article number: 905 |  doi: 10.1038/s41419-022-05317-3

IKCa channels control breast cancer metabolism including AMPK-driven autophagy Dominic Gross, Helmut Bischof [...] Robert Lukowski Article | 27 October 2022 | Article number: 902 |  doi: 10.1038/s41419-022-05329-z

Mutated lncRNA increase the risk of type 2 diabetes by promoting β cell dysfunction and insulin resistance Wan-Hui Guo, Qi Guo [...] Mi Yang Article | 27 October 2022 | Article number: 904 |  doi: 10.1038/s41419-022-05348-w

Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells Rosario Yerbes, Rocío Mora-Molina [...] Carmen Palacios Article | 27 October 2022 | Article number: 906 |  doi: 10.1038/s41419-022-05346-y

Loss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development Junguee Lee, Hae Joung Sul [...] Minho Shong Article | 26 October 2022 | Article number: 898 |  doi: 10.1038/s41419-022-05342-2

Gasdermin D mediates endoplasmic reticulum stress via FAM134B to regulate cardiomyocyte autophagy and apoptosis in doxorubicin-induced cardiotoxicity Ya'nan Qu, Rifeng Gao [...] Junbo Ge Article | 26 October 2022 | Article number: 901 |  doi: 10.1038/s41419-022-05333-3

The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization Quanfu Li, Yunkai Chu [...] Lei Huang Article | 26 October 2022 | Article number: 899 |  doi: 10.1038/s41419-022-05345-z

TAB182 aggravates progression of esophageal squamous cell carcinoma by enhancing β-catenin nuclear translocation through FHL2 dependent manner Aidi Gao, Zhenzi Su [...] Jundong Zhou Article | 26 October 2022 | Article number: 900 |  doi: 10.1038/s41419-022-05334-2

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma Tianyi Zhang, Yanxian Ren [...] Heng Zhou Review Article | 25 October 2022 | Article number: 897 |  doi: 10.1038/s41419-022-05351-1

Dynamic regulation of KIF15 phosphorylation and acetylation promotes focal adhesions disassembly in pancreatic cancer Zhiwei He, Jie Wang [...] Jianxin Jiang Article | 25 October 2022 | Article number: 896 |  doi: 10.1038/s41419-022-05338-y

MMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways Shoji F. Kenji, Keerthi Kurma [...] Patrick Legembre Article | 23 October 2022 | Article number: 895 |  doi: 10.1038/s41419-022-05352-0

Transcriptome reprogramming of Epstein-Barr virus infected epithelial and B cells reveals distinct host-virus interaction profiles Nian Ma, Juan Lu [...] Erle S. Robertson Article | 22 October 2022 | Article number: 894 |  doi: 10.1038/s41419-022-05327-1

Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development Wang-jun Yang, Rong-chang Cao [...] Guo-wei Zhang Article | 22 October 2022 | Article number: 893 |  doi: 10.1038/s41419-022-05322-6

Epstein Barr virus-mediated transformation of B cells from XIAP-deficient patients leads to increased expression of the tumor suppressor CADM1 Christine Engelmann, Patrick Schuhmachers [...] Christian Münz Article | 22 October 2022 | Article number: 892 |  doi: 10.1038/s41419-022-05337-z

HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer Guangying Xu, Liling Niu [...] Hui Li Article | 21 October 2022 | Article number: 888 |  doi: 10.1038/s41419-022-05335-1

E3 ubiquitin ligase RNF5 attenuates pathological cardiac hypertrophy through STING Lu-Lu Yang, Wen-Chang Xiao [...] Yan-Zhou Zhang Article | 21 October 2022 | Article number: 889 |  doi: 10.1038/s41419-022-05231-8

Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation Haibi Su, Chen Meng [...] Di Yang Article | 21 October 2022 | Article number: 890 |  doi: 10.1038/s41419-022-05321-7

Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death Ruven Wilkens, Anne Hoffrichter [...] Philipp Koch Article | 21 October 2022 | Article number: 887 |  doi: 10.1038/s41419-022-05340-4

NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer Xinrui Rao, Xiaoshu Zhou [...] Rui Zhou Article | 21 October 2022 | Article number: 891 |  doi: 10.1038/s41419-022-05336-0

The accumulation of miR-125b-5p is indispensable for efficient erythroblast enucleation Fang Fang, Lei Xu [...] Xuetao Pei Article | 21 October 2022 | Article number: 886 |  doi: 10.1038/s41419-022-05331-5

A TNFR1–UBCH10 axis drives lung squamous cell carcinoma dedifferentiation and metastasis through a cell-autonomous signaling loop Zuoxiang Xiao, Gongping Shi [...] Yinling Hu Article | 21 October 2022 | Article number: 885 |  doi: 10.1038/s41419-022-05308-4

Non-enzymatic role of SOD1 in intestinal stem cell growth Ying-Chao Wang, Xiao-Xu Leng [...] Jing-Yuan Fang Article | 20 October 2022 | Article number: 882 |  doi: 10.1038/s41419-022-05267-w

Zymosan-A promotes the regeneration of intestinal stem cells by upregulating ASCL2 Jicong Du, Lan Fang [...] Cong Liu Article | 20 October 2022 | Article number: 884 |  doi: 10.1038/s41419-022-05301-x

High-fat diet induced cyclophilin B enhances STAT3/lncRNA-PVT1 feedforward loop and promotes growth and metastasis in colorectal cancer Hanqing Guo, Kun Zhuang [...] Shuixiang He Article | 20 October 2022 | Article number: 883 |  doi: 10.1038/s41419-022-05328-0

Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications Angelo Iannielli, Mirko Luoni [...] Vania Broccoli Article | 19 October 2022 | Article number: 881 |  doi: 10.1038/s41419-022-05330-6

SHANK family on stem cell fate and development Xu Liu, Mengmeng Yuan [...] Yue Li Review Article | 18 October 2022 | Article number: 880 |  doi: 10.1038/s41419-022-05325-3

LCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis Juze Yang, Xinyi Qian [...] Pengyuan Liu Article | 18 October 2022 | Article number: 877 |  doi: 10.1038/s41419-022-05316-4

Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer's disease mouse model: a role for ER-mitochondria interaction Laura Tapella, Giulia Dematteis [...] Dmitry Lim Article | 18 October 2022 | Article number: 878 |  doi: 10.1038/s41419-022-05324-4

Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM Shihao Xu, Yin Celeste Cheuk [...] Ruiming Rong Article | 17 October 2022 | Article number: 876 |  doi: 10.1038/s41419-022-05305-7

The role of cancer-associated fibroblasts in tumorigenesis of gastric cancer Hui Sun, Xu Wang [...] Weiqi Sheng Review Article | 16 October 2022 | Article number: 874 |  doi: 10.1038/s41419-022-05320-8

Enhanced radiation-induced immunogenic cell death activates chimeric antigen receptor T cells by targeting CD39 against glioblastoma Ting Sun, Yanyan Li [...] Wei Yang Article | 16 October 2022 | Article number: 875 |  doi: 10.1038/s41419-022-05319-1

Self-restricted circular RNA circSOX2 suppressed the malignant progression in SOX2-amplified LUSC Yingkuan Liang, Nan Wang [...] Gaochao Dong Article | 15 October 2022 | Article number: 873 |  doi: 10.1038/s41419-022-05288-5

Loss of CASZ1 tumor suppressor linked to oncogenic subversion of neuroblastoma core regulatory circuitry Zhihui Liu, Xiyuan Zhang [...] Carol J. Thiele Article | 15 October 2022 | Article number: 871 |  doi: 10.1038/s41419-022-05314-6

The Cancermuts software package for the prioritization of missense cancer variants: a case study of AMBRA1 in melanoma Matteo Tiberti, Luca Di Leo [...] Elena Papaleo Article | 15 October 2022 | Article number: 872 |  doi: 10.1038/s41419-022-05318-2

ARHGEF3 regulates the stability of ACLY to promote the proliferation of lung cancer Feifei Zhou, Wenqian Ai [...] Tianyu Han Article | 14 October 2022 | Article number: 870 |  doi: 10.1038/s41419-022-05297-4

Inhibition of Mps1 kinase enhances taxanes efficacy in castration resistant prostate cancer Sadia Sarwar, Viacheslav M. Morozov [...] Alexander M. Ishov Article | 13 October 2022 | Article number: 868 |  doi: 10.1038/s41419-022-05312-8

c-Mpl-del, a c-Mpl alternative splicing isoform, promotes AMKL progression and chemoresistance Fei Li, Yuanyan Xiong [...] Qing Zhang Article | 13 October 2022 | Article number: 869 |  doi: 10.1038/s41419-022-05315-5

Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage Qianying Lv, Xinli Han [...] Hong Xu Article | 13 October 2022 | Article number: 867 |  doi: 10.1038/s41419-022-05313-7

Mesenchymal stem cells exosomal let-7a-5p improve autophagic flux and alleviate liver injury in acute-on-chronic liver failure by promoting nuclear expression of TFEB Dengna Lin, Hao Chen [...] Zhiliang Gao Article | 12 October 2022 | Article number: 865 |  doi: 10.1038/s41419-022-05303-9

Lineage-selective super enhancers mediate core regulatory circuitry during adipogenic and osteogenic differentiation of human mesenchymal stem cells Chen Wang, Wen Tian [...] Yan Guo Article | 12 October 2022 | Article number: 866 |  doi: 10.1038/s41419-022-05309-3

Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice Joseph Flores, Marie-Lyne Fillion & Andréa C. LeBlanc Article | 11 October 2022 | Article number: 864 |  doi: 10.1038/s41419-022-05290-x

mTORC1 signaling pathway integrates estrogen and growth factor to coordinate vaginal epithelial cells proliferation and differentiation Shuo Wan, Yadong Sun [...] Meixiang Yang Article | 11 October 2022 | Article number: 862 |  doi: 10.1038/s41419-022-05293-8

Neddylation-mediated degradation of hnRNPA2B1 contributes to hypertriglyceridemia pancreatitis Wei Chen, Yilong Wang [...] Yan Zhao Article | 11 October 2022 | Article number: 863 |  doi: 10.1038/s41419-022-05310-w

HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis Xiaodong Su, Yuan Xie [...] Fusheng Liu Article | 08 October 2022 | Article number: 861 |  doi: 10.1038/s41419-022-05304-8

PLEKHH2 binds β-arrestin1 through its FERM domain, activates FAK/PI3K/AKT phosphorylation, and promotes the malignant phenotype of non-small cell lung cancer Rui Wang, Si Wang [...] Yang Liu Article | 08 October 2022 | Article number: 858 |  doi: 10.1038/s41419-022-05307-5

CircRNF144B/miR-342-3p/FBXL11 axis reduced autophagy and promoted the progression of ovarian cancer by increasing the ubiquitination of Beclin-1 Wenting Song, Zhirui Zeng [...] Fengrui Wu Article | 08 October 2022 | Article number: 857 |  doi: 10.1038/s41419-022-05286-7

S-nitrosylation of CSF1 receptor increases the efficacy of CSF1R blockage against prostate cancer Fakiha Firdaus, Manish Kuchakulla [...] Himanshu Arora Article | 08 October 2022 | Article number: 859 |  doi: 10.1038/s41419-022-05289-4

Inhibition of p38 MAPK or immunoproteasome overcomes resistance of chronic lymphocytic leukemia cells to Bcl-2 antagonist venetoclax Damjan Avsec, Marja Škrlj Miklavčič [...] Irena Mlinarič-Raščan Article | 08 October 2022 | Article number: 860 |  doi: 10.1038/s41419-022-05287-6

Tension of plus-end tracking protein Clip170 confers directionality and aggressiveness during breast cancer migration Yunfeng Hu, Qiu Xie [...] Jun Guo Article | 08 October 2022 | Article number: 856 |  doi: 10.1038/s41419-022-05306-6

Retraction Note: Identification of protein kinase inhibitors to reprogram breast cancer cells Jie Yuan, Fan Zhang [...] Qin Yang Retraction | 07 October 2022 | Article number: 853 |  doi: 10.1038/s41419-022-05311-9

Retraction Note to: RIPK3 interactions with MLKL and CaMKII mediate oligodendrocytes death in the developing brain Yi Qu, Jun Tang [...] Dezhi Mu Retraction | 07 October 2022 | Article number: 854 |  doi: 10.1038/s41419-022-05252-3

The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms Qibo Huang, Jie Mo [...] Bixiang Zhang Review Article | 07 October 2022 | Article number: 852 |  doi: 10.1038/s41419-022-05268-9

The ataxia-linked E1081Q mutation affects the sub-plasma membrane Ca2+-microdomains by tuning PMCA3 activity Francesca Vallese, Lorenzo Maso [...] Ernesto Carafoli Article | 07 October 2022 | Article number: 855 |  doi: 10.1038/s41419-022-05300-y

Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity Ruru Wang, Yajing Shang [...] Guoping Zhao Article | 06 October 2022 | Article number: 851 |  doi: 10.1038/s41419-022-05302-w

TrkC-mediated inhibition of DJ-1 degradation is essential for direct regulation of pathogenesis of hepatocellular carcinoma Min Soo Kim, Won Sung Lee [...] Wook Jin Article | 06 October 2022 | Article number: 850 |  doi: 10.1038/s41419-022-05298-3

Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders Haiyu Li, Yongyao Tang [...] Yaokai Chen Article | 04 October 2022 | Article number: 849 |  doi: 10.1038/s41419-022-05225-6

Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer Xiaolong Tang, Yahang Liang [...] Hui Qu Article | 04 October 2022 | Article number: 848 |  doi: 10.1038/s41419-022-05299-2

Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer Mariana Suaya, Gonzalo Manuel Sánchez [...] Matías Blaustein Review Article | 03 October 2022 | Article number: 846 |  doi: 10.1038/s41419-022-05250-5

PD-L1 induction via the MEK-JNK-AP1 axis by a neddylation inhibitor promotes cancer-associated immunosuppression Shizhen Zhang, Xiahong You [...] Yi Sun Article | 03 October 2022 | Article number: 844 |  doi: 10.1038/s41419-022-05292-9

Histone chaperone ASF1A accelerates chronic myeloid leukemia blast crisis by activating Notch signaling Xiaolin Yin, Minran Zhou [...] Chunyan Chen Article | 03 October 2022 | Article number: 842 |  doi: 10.1038/s41419-022-05234-5

DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism Zhenzhen Li, Yue Tan [...] Xiangjian Luo Article | 03 October 2022 | Article number: 845 |  doi: 10.1038/s41419-022-05291-w

Regulation of KDM5C stability and enhancer reprogramming in breast cancer Qiong Xiao, Chen-Yu Wang [...] Min Wu Article | 03 October 2022 | Article number: 843 |  doi: 10.1038/s41419-022-05296-5

RUNDC3A/SNAP25/Akt signaling mediates tumor progression and chemoresistance in gastric neuroendocrine carcinoma Ziqi Lin & Hang Fai Kwok Comment | 01 October 2022 | Article number: 840 |  doi: 10.1038/s41419-022-05294-7

GSDME deficiency leads to the aggravation of UVB-induced skin inflammation through enhancing recruitment and activation of neutrophils Yujie Chen, Ni Lian [...] Xu Chen Article | 01 October 2022 | Article number: 841 |  doi: 10.1038/s41419-022-05276-9

PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer Rama Krishna Nimmakayala, Ayoola O. Ogunleye [...] Moorthy P. Ponnusamy Article | 01 October 2022 | Article number: 839 |  doi: 10.1038/s41419-022-05258-x

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