Nature Reviews Cancer contents December 2012 Volume 12 Number 12 pp 793-886

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TABLE OF CONTENTS
December 2012 Volume 12 Number 12
Impact Factor 37.545 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Genomic instability in cancer  Featured article: DNA repair dysregulation from cancer driver to therapeutic target Nicola J. Curtin
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Nature and Nature Reviews Cancer COLLECTION ON CANCER METABOLISM This joint Collection from Nature and Nature Reviews Cancer highlights recent progress in the field and the promise of therapeutics based on interfering with metabolic pathways. Access the Web Focus at: www.nature.com/focus/cancermetabolism Papers in the reprint collection are freely available thanks to sponsorship from Teva Pharmaceuticals
RESEARCH HIGHLIGHTS Top Metastasis: Converging targets p793 | doi:10.1038/nrc3411 Tavazoie and colleagues show that three microRNAs target apolipoprotein E, which is a suppressor of melanoma metastasis. PDF Glioma: Tumour cells in reverse p794 | doi:10.1038/nrc3404 Inder Verma and colleagues provide evidence that, at least in mice, mature neurons and astrocytes can be transformed and can dedifferentiate to form gliomas. PDF Metastasis: Elf represses snail p795 | doi:10.1038/nrc3406 A recent publication in Nature Cell Biology indicates that the transcription factor ELF5 suppresses epithelial to mesenchymal transition and metastasis through repression of SNAI2. PDF IN THE NEWS Melanoma: Seeing red p795 | doi:10.1038/nrc3412 A new study suggests that people with red hair and fair skin are at risk from developing melanoma because of a particular pigment in their skin. PDF Tumour immunology: Context is key for TSLP p796 | doi:10.1038/nrc3405 Two new studies published in Cancer Cell characterize a context-dependent tumour suppressive role for the interleukin-like inflammatory protein TSLP. PDF Signalling: New roles for TLR2 p796 | doi:10.1038/nrc3407 Jenkins and colleagues identify a non-inflammatory role of TLR2 in gastric tumorigenesis. PDF MicroRNAs: Editing changes the meaning p797 | doi:10.1038/nrc3413 Editing of a microRNA (miRNA) is impaired in gliomas, and the non-edited and edited miRNAs have different gene targets, which promote and suppress invasive activity, respectively. PDF Metabolism: Warburg behind the butyrate paradox? p798 | doi:10.1038/nrc3401 A new study finds that metabolism might converge with epigenetic gene regulation to explain the context-dependent effects of the metabolite butyrate on colon cell proliferation. PDF Lymphoma: Epigenetic therapy gains momentum p798 | doi:10.1038/nrc3402 Two groups have reported the discovery of small-molecule inhibitors of EZH2 that have the ability to selectively kill lymphoma cells with EZH2-activating mutations. PDF Leukaemia: Early changes p799 | doi:10.1038/nrc3403Three groups have used human trisomy 21 fetal liver cells or human trisomy 21 induced pluripotent stem cells (iPSCs) to examine the effects of trisomy 21 on the early stages of haematopoiesis. PDF IN BRIEF Metastasis: The clot thickens | Therapeutics: BET spreading | Leukaemia: Supporting role | Signalling: All together now PDF Cancer JOBS of the week MRes / PhD Studentships in Cancer Research University of Birmingham – College of Medical & Dental Sciences Physician-Scientist, Genitourinary Cancer The University of Chicago (U of C) Research Technologist - Stem Cells and Cancer Massachusetts General Hospital & Harvard Medical School Outstanding Breast Cancer Scientist Opportunity Cedars-Sinai Medical Center Principal Investigators in Cancer Research Institut de recherches cliniques de Montréal (IRCM) More Science jobs from Cancer EVENT 1st Symposium of the Cancer Research Center of Lyon 13.-15.02.13 Lyon, France More science events from
REVIEWS		Top
Article series: Genomic instability in cancer DNA repair dysregulation from cancer driver to therapeutic target Nicola J. Curtin p801 | doi:10.1038/nrc3399 The DNA damage response (DDR) is often altered in tumour cells and this Review discusses the many strategies to target the pathways that comprise the DDR as single agents and in combination to produce synthetic lethality specifically in tumour cells. Abstract | Full Text | PDF
Medulloblastomics: the end of the beginning Paul A. Northcott, David T. W. Jones, Marcel Kool, Giles W. Robinson, Richard J. Gilbertson, Yoon-Jae Cho, Scott L. Pomeroy, Andrey Korshunov, Peter Lichter, Michael D. Taylor & Stefan M. Pfister p818 | doi:10.1038/nrc3410 Medulloblastoma has been the subject of numerous genomics and transcriptomics studies that have led to this disease being subclassified into various clinically meaningful groups and to advances in understanding the biology of these subgroups, with implications for treatment. Abstract | Full Text | PDF
Future directions in cancer prevention Asad Umar, Barbara K. Dunn & Peter Greenwald p835 | doi:10.1038/nrc3397 Based on previous successes and failures, this Review discusses potential future directions for cancer prevention that include the use of genetic, proteomic and other molecular approaches to identify pathways that could be modified during cancer initiation. The use of immunotherapies for cancer prevention is also discussed. Abstract | Full Text | PDF
The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes Azra Raza & Naomi Galili p849 | doi:10.1038/nrc3321 Myelodysplastic syndromes (MDS) are malignant clonal disorders of haematopoietic stem cells and their microenvironment, affecting older individuals. Although emerging insights establish an association between molecular abnormalities (such as specific chromosomal abnormalities) and the phenotypic heterogeneity of MDS, as outlined in this Review the origin and progression of MDS remain enigmatic. Abstract | Full Text | PDF
Immunogenic cell death and DAMPs in cancer therapy Dmitri V. Krysko, Abhishek D. Garg, Agnieszka Kaczmarek, Olga Krysko, Patrizia Agostinis & Peter Vandenabeele p860 | doi:10.1038/nrc3380 In recent years a new concept of immunogenic cell death (ICD) has emerged. In this Review, the authors discuss the role of endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in regulating the immunogenicity of dying cancer cells and how this might relate to therapeutic intervention. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Human tumour viruses and the deregulation of cell polarity in cancer Lawrence Banks, David Pim & Miranda Thomas p877 | doi:10.1038/nrc3400 Despite displaying characteristics of tumour suppressors, the core regulators of epithelial cell polarity are rarely mutated in tumours, and it is still unclear whether they directly contribute to cancer development. However, data from human tumour viruses provide compelling evidence of a central role for the perturbation of cell polarity in cancer. Abstract | Full Text | PDF
Corrigendum: Pushing the limits of targeted therapy in chronic myeloid leukaemia Thomas O'Hare, Matthew S. Zabriskie, Anna M. Eiring & Michael W. Deininger p886 | doi:10.1038/nrc3408 Full Text | PDF
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