Nature Reviews Immunology Contents December 2012 Volume 12 Number 12 pp 805-864

TABLE OF CONTENTS
December 2012 Volume 12 Number 12		Advertisement
Impact Factor 33.287 *	In this issue Research Highlights Progress Reviews Perspectives Correspondence Also this month  Featured article: The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling Peter Vandenabeele & Mathieu J. M. Bertrand	Fast Quantitative Western Blotting The new V3 Western Workflow™ from Bio-Rad streamlines your western blot protocol and delivers reliable results faster. visualize and verify results at each step of your experiment, and quantify your proteins with confidence. See more V3 Western Workflow here.See more V3 Western Workflow here.
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RESEARCH HIGHLIGHTS Top Antiviral immunity: Immune control of endogenous retroviruses p805 | doi:10.1038/nri3355 The immune system protects against infectious endogenous retroviruses and associated tumour formation. PDF Regulatory T cells: Working on a commitment p806 | doi:10.1038/nri3350 FOXO1 has a crucial role in the function of TReg cells as well as in their commitment. PDF T cell responses: Jagged gives an edge to TH1 cells p806 | doi:10.1038/nri3356 Crosstalk between the complement and Notch systems regulates human TH1 cell responses. PDF Regulatory T cells: TReg cells separate the weak from the strong p806 | doi:10.1038/nri3360 TReg cells enhance the avidity of CD8+ T cell responses to foreign antigens. PDF B cells: IL-21 promotes B10 cell population expansion p808 | doi:10.1038/nri3346 Expression of MHC class II molecules, CD40 and IL-21R by B10 cells is required for their regulatory function. PDF B cell responses: Born to be (a bit) wild p808 | doi:10.1038/nri3347 Wild mice carry a promoter polymorphism in an inhibitory receptor gene that predisposes towards autoimmune disease. PDF T cells: TCR affinity goes asymmetric p809 | doi:10.1038/nri3340 Antigen-TCR affinity dictates effector T cell fate by determining the polarity of T cell divisions. PDF Innate immunity: Splice-tailored to fit the bug p810 | doi:10.1038/nri3343 Alternative splicing of a hypervariable PRR confers pathogen specificity in insects. PDF IN THE NEWS Old drug, new price? p810 | doi:10.1038/nri3348 A leukaemia therapy shows promise in multiple sclerosis — but at what cost? PDF Signalling: New roles for TLR2 p810 | doi:10.1038/nri3351 Jenkins and colleagues identify a non-inflammatory role of TLR2 in gastric tumorigenesis. PDF IN BRIEF Innate immunity: p38δ-PKD1-PTEN signalling promotes neutrophil chemotaxis | T cells: The MALT1 switch in autoimmunity | Inflammation: The GEF way to MYD88-dependent vascular permeabilization | Innate immunity: TLR3 — enhancing pluripotency | Autoimmunity: Self DNAs can STING | Innate immunity: X factor shows that the old ways still work PDF Immunology JOBS of the week Post Doctorate Vaxine Pty Ltd Postdoctoral Positions Available Immediately Saint Louis University School of Medicine Staff Scientist National Institutes of Health (NIH) / Dept of Health and Human Services (DHHS) Researchers University of Copenhagen Immunology and Parasitology Research Jason P. Gigley More Science jobs from Immunology EVENT 5th ImmunoTherapeutics & ImmunoMonitoring 31.01.-01.02.13 San Diego, US More science events from
PROGRESS		Top
NLRC5: a key regulator of MHC class I-dependent immune responses Koichi S. Kobayashi & Peter J. van den Elsen p813 | doi:10.1038/nri3339 The identification of NLRC5 as a transcriptional transactivator of MHC class I genes has shed light on the regulation of MHC class I expression. This Progress article summarizes the recent advances in the field and highlights some of the questions that still remain to be addressed. Abstract | Full Text | PDF
REVIEWS		Top
New concepts in the generation and functions of IgA Oliver Pabst p821 | doi:10.1038/nri3322 Secretory IgA is an important first-line defence mechanism that protects mucosal barrier tissues from environmental microorganisms and toxins. Here, the author discusses the pathways that lead to the generation of secretory IgA and proposes a model to describe the variable quality of IgA responses against pathogens and commensals. Abstract | Full Text | PDF
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling Peter Vandenabeele & Mathieu J. M. Bertrand p833 | doi:10.1038/nri3325 Inhibitor of apoptosis proteins (IAPs) contribute to innate immune responses not only through cell death control but also as essential components of pattern-recognition receptor (PRR) signalling. Here, the ubiquitin ligase activity of IAPs downstream of PRR activation is discussed, along with its therapeutic implications. Abstract | Full Text | PDF
Recognition of CD1d-restricted antigens by natural killer T cells Jamie Rossjohn, Daniel G. Pellicci, Onisha Patel, Laurent Gapin & Dale I. Godfrey p845 | doi:10.1038/nri3328 Here, the authors discuss how the T cell receptors expressed by natural killer T cells are able to recognize and respond to an array of self and foreign lipid antigens that are presented on CD1d molecules. They explain how a better understanding of these processes could be exploited for therapeutic purposes. Abstract | Full Text | PDF
PERSPECTIVES		Top
INNOVATION Functional immunoimaging: the revolution continues Philippe Bousso & Hélène D. Moreau p858 | doi:10.1038/nri3342 New immunoimaging approaches that allow cell dynamics and function to be assessed simultaneously promise another decade of immunological insights in health and disease. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Standardization in flow cytometry: correct sample handling as a priority Andrea Valle, Norma Maugeri, Angelo A. Manfredi & Manuela Battaglia p864 | doi:10.1038/nri3158-c3 Full Text | PDF
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