Nature Review Cancer contents March 2014 Volume 14 Number 4 pp 209-289

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TABLE OF CONTENTS
April 2014 Volume 14 Number 4		Advertisement
Impact Factor 35*	In this issue Comment Research Highlights Reviews Perspectives Also this month Article series: Clinical insights Featured article: Targeting Bruton's tyrosine kinase in B cell malignancies Rudi W. Hendriks, Saravanan Yuvaraj & Laurens P. Kil	Cancer Metabolism Webinar Available On Demand Seahorse Bioscience presents: Understanding the tumor micro environment, and its effect on tumor metabolism, progression and therapy. Watch this On Demand webinar presented by Robert Gillies, Ph.D., Moffit Cancer Center. Watch this webinar: www.seahorsebio.com/aacretoc
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Article series: Clinical insights Comment: Does everyone develop covert cancer? Mel Greaves Published online: 13 March 2014 p209 | doi:10.1038/nrc3703 Do we all develop a covert cancer as we age? Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Leukaemia: A pre-leukaemic reservoir Published online: 06 March 2014 p212 | doi:10.1038/nrc3706 John Dick and colleagues have found that pre-leukaemic haematopoietic stem cells (HSCs) are present in patients with acute myeloid leukaemia. These cells contain clinically relevant mutations but can act as functional HSCs and undergo multilineage differentiation. Furthermore, these cells seem to be resistant to chemotherapy and could contribute to relapse. PDF Pancreatic Cancer: Spotlight on BRG1 Published online: 13 March 2014 p213 | doi:10.1038/nrc3709 Expression of BRG1, an ATPase subunit of SWI/SNF complexes, can suppress the formation of intraductal papillary mucinous neoplasm. PDF Tumour microenvironment: More than just a mutagen Published online: 24 March 2014 p213 | doi:10.1038/nrc3710 Independent of its mutagenic effects, induction of an innate inflammatory response by ultraviolet radiation can promote angiotropism and metastasis in mice with melanoma. PDF Bladder cancer: Seemingly similar Published online: 27 February 2014 p214 | doi:10.1038/nrc3704 Two papers have found that high-grade bladder cancer can be spilt into several subtypes, including luminal and basal subtypes, which match these subtypes in breast cancer. PDF Epigenetics: Histone methyltransferase mutations promote leukaemia Published online: 27 February 2014 p214 | doi:10.1038/nrc3705 Zhu et al. identified mutations in the histone-lysine N-methyltransferase SETD2 and showed that these mutations cooperate with other genetic aberrations to promote acute leukaemia. PDF Pluripotency: Partial reprogramming induces cancer Published online: 24 March 2014 p216 | doi:10.1038/nrc3713 A paper in Cell shows that partial reprogramming of somatic cells induces epithelial tumorigenesis. PDF Tumour suppressors: Hippo promotes microRNA processing Published online: 24 March 2014 p216 | doi:10.1038/nrc3715 Mori et al. show that the Hippo pathway component Yes-associated protein (YAP) controls processing of microRNAs through regulating the Microprocessor complex in a cell density-dependent manner and that this is linked to tumour suppression. PDF Chromatin remodelling: Looking vulnerable Published online: 13 March 2014 p217 | doi:10.1038/nrc3708 Four recent papers have highlighted the importance of the disruption of the chromatin-modifying SWI/SNF axis in human cancer. PDF Signalling: Loss of Cbl-b unleashes anti-metastatic natural killer cells Published online: 13 March 2014 p218 | doi:10.1038/nrc3707 Paolino et al. have shown that deletion or inhibition of casitas B-lineage lymphoma-b (Cbl-b) decreases metastasis in various mouse tumour models by activating natural killer cells. PDF IN THE NEWS Probing a rare tumour type Published online: 24 March 2014 p218 | doi:10.1038/nrc3714 A high school student has helped to study the underlying genetic cause of a rare tumour type, of which she is also a survivor. PDF IN BRIEF Immunotherapy: Promising results from autologous T cell transfer | Therapy: Combination and dosing schedule are key | Signalling: Connecting metabolism and proliferation | Inflammation: Determinants of neoplastic sites PDF Cancer JOBS of the week Molecular Mechanisms and Translational Investigations of Advanced Prostate Cancer Cleveland Clinic Cancer Pathobiology University of Alabama at Birmingham, Department of Pathology Research Fellowship in Translational Bioinformatics at the Case Comprehensive Cancer Center Case Western Reserve University Faculty Positions in Translational Cancer Biology Duke University PostDoctoral Research Scientist proposal in Epigenetic and Cancer Inserm (CDD) More Science jobs from Cancer EVENT Cancer Genomics 30.06.14 Cambridge, UK More science events from
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REVIEWS		Top
Targeting Bruton's tyrosine kinase in B cell malignancies Rudi W. Hendriks, Saravanan Yuvaraj & Laurens P. Kil Published online: 24 March 2014 p219 | doi:10.1038/nrc3702 Bruton's tyrosine kinase (BTK) is important in B cell receptor (BCR) signalling, and so BTK is altered in many types of B cell-derived malignancy. This Review discusses the molecular biology of BTK, its involvement in the pathogenesis of B cell malignancies and the current efforts to therapeutically target it. Abstract | Full Text | PDF
Roles of F-box proteins in cancer Zhiwei Wang, Pengda Liu, Hiroyuki Inuzuka & Wenyi Wei Published online: 24 March 2014 p233 | doi:10.1038/nrc3700 F-box proteins, which are the substrate-recognition subunits of SKP1-cullin 1-F-box protein (SCF) E3 ubiquitin ligase complexes, have pivotal roles in multiple cellular processes. This Review discusses how dysregulation of F-box protein-mediated proteolysis contributes to tumorigenesis. Abstract | Full Text | PDF | Supplementary information
Oncogenic protein interfaces: small molecules, big challenges Tracy L. Nero, Craig J. Morton, Jessica K. Holien, Jerome Wielens & Michael W. Parker Published online: 13 March 2014 p248 | doi:10.1038/nrc3690 This Review describes some of the latest techniques that are being used to discover modulators of protein-protein interactions and how current drug discovery approaches have been adapted to successfully target these interfaces. Abstract | Full Text | PDF | Supplementary information
Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential Amy S. Lee Published online: 24 March 2014 p263 | doi:10.1038/nrc3701 The glucose-regulated proteins (GRPs) are stress-inducible chaperones that mostly reside in the endoplasmic reticulum or the mitochondria. Recent advances have shown that the GRPs are involved in the regulation of cell signalling, proliferation, invasion, apoptosis, inflammation and immunity. Agents that target the GRPs are being developed as potential cancer therapies. Abstract | Full Text | PDF | Supplementary information
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PERSPECTIVES		Top
OPINION The prenatal origins of cancer Glenn M. Marshall et al. Published online: 06 March 2014 p277 | doi:10.1038/nrc3679 The early detection and prevention of childhood cancer is an important area of cancer research. In this Opinion article, the authors argue that identifying whether some childhood cancers arise from an aberrant prenatal cell population could help with disease prevention. Abstract | Full Text | PDF
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