Nature Reviews Nephrology - Table of Contents alert Volume 10 Issue 4

TABLE OF CONTENTS
April 2014 Volume 10 Number 4
Impact Factor 7.943 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Potential approaches to reverse or repair renal fibrosis Desiree Tampe & Michael Zeisberg
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RESEARCH HIGHLIGHTS Top Chronic kidney disease: Empagliflozin—one step closer to glycaemic control in patients with type II diabetes and CKD? Published online: 18 February 2014 p181 | doi:10.1038/nrneph.2014.20 PDF Anaemia: Mutations in C5 explain eculizumab resistance Published online: 25 February 2014 p182 | doi:10.1038/nrneph.2014.30 PDF Pharmacology: NHERF3 regulates MRP4-mediated efflux of drug molecules in the kidneys Published online: 04 February 2014 p183 | doi:10.1038/nrneph.2014.17 PDF Transplantation: Sitagliptin—balancing cardiovascular risk, hyperglycaemia and safety Published online: 11 February 2014 p183 | doi:10.1038/nrneph.2014.18 PDF Acute kidney injury: Critical role of complement in EndMT Published online: 11 February 2014 p183 | doi:10.1038/nrneph.2014.19 PDF Genetics: Epigenetic reversal attenuates renal fibrosis Published online: 18 February 2014 p184 | doi:10.1038/nrneph.2014.21 PDF Glomerular disease: Frequency of podocyte-related gene mutations in FSGS Published online: 25 February 2014 p184 | doi:10.1038/nrneph.2014.29 PDF IN BRIEF Hypertension: Predictive biomarkers identified for renal denervation | Basic research: Anoctamin 1—role in proton secretion and protein resorption | Chronic kidney disease: Indices of insulin sensitivity put to the test | Diabetes: ACE2 overactivity and hyperfiltration in diabetic nephropathy PDF
NEWS AND VIEWS		Top
Immunology: TREG cells in transplantation—a double-edged sword? Fadi G. Lakkis Published online: 11 March 2014 p185 | doi:10.1038/nrneph.2014.35 Immunosuppressive drugs commonly used in transplantation and autoimmune diseases are unfortunately associated with increased cancer incidence. Now, a new study reports a direct relationship between the number of regulatory T cells in the blood and the risk of developing invasive skin cancer in kidney transplant recipients. Full Text | PDF
Hypertension: Is the sham procedure 'toxic' for renal denervation? Costas Tsioufis Published online: 04 March 2014 p186 | doi:10.1038/nrneph.2014.28 The announcement by Medtronic that the SYMPLICITY HTN-3 trial failed to meet its primary effectiveness end point calls the blood pressure lowering effects of renal denervation into question. However, its safety is proven, which raises the possibility that the procedure might have beneficial effects on the kidneys beyond blood pressure reduction. Full Text | PDF
Transplantation: Early hospital readmissions after kidney transplantation Martha Pavlakis Published online: 04 March 2014 p188 | doi:10.1038/nrneph.2014.32 A new study reports that 30.5% of kidney transplant recipients have an early hospital readmission (EHR; defined as within 30 days of discharge). As EHR is a strong independent risk factor for allograft loss and mortality, efforts should be made to implement and improve systems to minimize risk of EHR in these patients. Full Text | PDF
Hypertension: Treatment-resistant hypertension—a risk factor for ESRD Markus P. Schlaich Published online: 25 February 2014 p189 | doi:10.1038/nrneph.2014.26 Failure to achieve blood pressure control in patients with hypertension despite the use of three or more antihypertensive drugs is becoming more frequent. Although treatment-resistant hypertension has been associated with an increased risk of cardiovascular events, new evidence indicates treatment-resistant hypertension is an important risk factor for end-stage renal disease. Full Text | PDF
Transplantation: Pulsatile perfusion—time for a prospective trial Hans A. Gritsch Published online: 25 February 2014 p191 | doi:10.1038/nrneph.2014.27 Pulsatile perfusion is increasingly being used to preserve kidneys harvested from non-standard-criteria donors. Indeed, retrospective analyses have shown that machine preservation is associated with reduced rates of delayed graft function. However, well-designed prospective clinical trials are needed to evaluate its impact on organ discard, rejection, long-term graft function, and cost. Full Text | PDF
REVIEWS		Top
Acute kidney injury—epidemiology, outcomes and economics Oleksa Rewa & Sean M. Bagshaw Published online: 21 January 2014 p193 | doi:10.1038/nrneph.2013.282 AKI is associated with an increased risk of adverse outcomes, including short-term and long-term mortality, incident CKD, accelerated progression to end-stage renal disease and reduced health-related quality of life. The incidence of the disorder is increasing rapidly worldwide. In this Review, the authors discuss the epidemiology, outcomes and economic impact of AKI in developed and developing countries. Abstract | Full Text | PDF
Noncardiovascular mortality in CKD: an epidemiological perspective Dinanda J. de Jager, Marc G. Vervloet & Friedo W. Dekker Published online: 04 February 2014 p208 | doi:10.1038/nrneph.2014.8 Patients with chronic kidney disease (CKD) are known to have increased all-cause and cardiovascular mortality. Of late, it has been recognized that these patients also have increased noncardiovascular mortality. Here, the authors discuss both cardiovascular and nonocardiovascular mortality in CKD, provide examples of traditional cardiovascular risk factors that also seem to be associated with noncardiovascular mortality, and summarize the potential pathophysiological mechanisms involved. Abstract | Full Text | PDF
Biomarkers for kidney transplant rejection Denise J. Lo, Bruce Kaplan & Allan D. Kirk Published online: 21 January 2014 p215 | doi:10.1038/nrneph.2013.281 In this Review, Lo et al. discuss biomarkers of rejection in kidney transplantation, study design and the statistical analyses for biomarker validation. They also provide an overview of potential biomarkers in a variety of substrates that could serve as surrogate end points in clinical trials and aid physicians in clinical decision-making. Abstract | Full Text | PDF
Potential approaches to reverse or repair renal fibrosis Desiree Tampe & Michael Zeisberg Published online: 11 February 2014 p226 | doi:10.1038/nrneph.2014.14 The notion that chronic kidney disease (CKD) can be repaired has spurred intense research over the past decade and has focused on antifibrotic therapies, with numerous strategies being explored preclinically and clinically. In this Review, the authors describe the therapeutic concepts and molecular targets under investigation to inhibit or even reverse CKD. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2012. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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