The EMBO Journal Table of Contents for 1 August 2014; Vol. 33, No. 15

1 August 2014 | Volume 33, Number 15 Submit Table of Contents Obituary Have you seen? Articles Resource Corrigendum Volume 33, Number 15 Obituary Walter J Gehring (1939–2014) Marek Mlodzik and Georg Halder Published online 08.07.2014 Have you seen? Stalking the mitochondrial ATP synthase: Ina found guilty by association Characterization of Ina17 and Ina22 defines a novel inner mitochondrial membrane assembly complex, INAC, involved in F1F0‐ATPase biogenesis. David A Stroud and Michael T Ryan Published online 18.06.2014 Not an inside job: non‐coded amino acids compromise the genetic code The editing activity of amino‐acyl‐tRNA synthetase LeuRS protects bacteria from incorporating toxic non‐natural amino acids that arise during hypoxic growth. Lluís Ribas de Pouplana Published online 21.06.2014 Pink1, the first ubiquitin kinase Several recent articles reveal Parkin activation as the first‐ever physiological function of ubiquitin phosphorylation. Xinde Zheng and Tony Hunter Published online 18.06.2014 Articles The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo‐ATP synthase The F1F0‐ATP synthase provides the vast majority of ATP under aerobic conditions. New assembly factors Ina17 and Ina22 ensure the stable connection of the soluble F1‐domain to the membrane‐embedded F0‐domain. Oleksandr Lytovchenko, Nataliia Naumenko, Silke Oeljeklaus, Bernhard Schmidt, Karina von der Malsburg, Markus Deckers, Bettina Warscheid, Martin van der Laan, and Peter Rehling Published online 18.06.2014 The physiological target for LeuRS translational quality control is norvaline Aminoacyl‐tRNA‐synthetase (AARS) editing hydrolyses mischarged tRNAs. LeuRS editing is not a response to poor selectivity between Leu and Ile, as previously suggested, but targets the non‐standard amino acid norvaline during hypoxic growth. Nevena Cvetesic, Andrés Palencia, Ivan Halasz, Stephen Cusack, and Ita Gruic‐Sovulj Published online 16.06.2014 Listeria monocytogenes induces IFNβ expression through an IFI16‐, cGAS‐ and STING‐dependent pathway While bacterium‐derived cyclic‐di‐AMP triggers interferon responses in murine cells, Listeria monocytogenes‐infected human myeloid cells utilize an innate immune sensory pathway that directly recognizes bacterial DNA. Kathrine Hansen, Thaneas Prabakaran, Anders Laustsen, Sofie E Jørgensen, Stine H Rahbæk, Søren B Jensen, Rikke Nielsen, Jess H Leber, Thomas Decker, Kristy A Horan, Martin R Jakobsen, and Søren R Paludan Published online 26.06.2014 MicroRNA‐125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease Direct regulation of tau kinases and phosphatases by an Alzheimer's disease‐overexpressed miRNA promotes pathological tau phosphorylation and accompanying learning and memory defects. Julia Banzhaf‐Strathmann, Eva Benito, Stephanie May, Thomas Arzberger, Sabina Tahirovic, Hans Kretzschmar, André Fischer, and Dieter Edbauer Published online 07.07.2014 The SNARE protein vti1a functions in dense‐core vesicle biogenesis Neurotransmitter release depends on the SNARE protein vti1a, which is unexpectedly not required for final fusion of dense‐core vesicles, but for their generation. Alexander M Walter, Julia Kurps, Heidi de Wit, Susanne Schöning, Trine L Toft‐Bertelsen, Juliane Lauks, Iwona Ziomkiewicz, Annita N Weiss, Alexander Schulz, Gabriele Fischer von Mollard, Matthijs Verhage, and Jakob B Sørensen Published online 05.06.2014 Crosstalk between BRCA‐Fanconi anemia and mismatch repair pathways prevents MSH2‐dependent aberrant DNA damage responses Loss of the DNA mismatch recognition factor MSH2 suppresses interstrand crosslink sensitivity in cells with specific defects in the BRCA1/FA pathway, suggesting that pathway crosstalk prevents toxic DNA damage responses. Min Peng, Jenny Xie, Anna Ucher, Janet Stavnezer, and Sharon B Cantor Published online 25.06.2014 Resource Spatio‐temporally precise activation of engineered receptor tyrosine kinases by light A new method for spatially and temporally controlled activation of receptor tyrosine kinases is described. Bacterial LOV domains allow blue light‐activated dimerization of ligand‐insensitive FGFR, EGFR or RET receptors and mitogenic signalling. Michael Grusch, Karin Schelch, Robert Riedler, Eva Reichhart, Christopher Differ, Walter Berger, Álvaro Inglés‐Prieto, and Harald Janovjak Published online 01.07.2014 Corrigendum Heme regulates gene expression by triggering Crm1‐dependent nuclear export of Bach1 Hiroshi Suzuki, Satoshi Tashiro, Shusuke Hira, Jiying Sun, Chikara Yamazaki, Yukari Zenke, Masao Ikeda‐Saito, Minoru Yoshida, and Kazuhiko Igarashi Published online 01.08.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.